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1. County-level radon exposure and all-cause mortality risk among Medicare beneficiaries

Author:
Schwartz, Joel D.,   et al.   ; Yitshak-Sade, Maayan; Blomberg, Annelise J.; Zanobetti, Antonella; Coull, Brent A.; Kloog, Itai; Dominici, Francesca; Koutrakis, Petros;     Show all 8 Authors
Source:
Environment international 2019 v.130 pp. 104865
ISSN:
0160-4120
Subject:
cohort studies; construction materials; diabetes; exposure assessment; heart failure; lung neoplasms; mortality; particulates; public health; radionuclides; radon; risk factors; soil; Northeastern United States
Abstract:
... Radon is an inert gas formed from the decay of naturally-occurring materials in the earth's crust. It infiltrates into homes from soil, water, and construction materials. Its decay products are radionuclides, which attach to ambient particles. Residential radon is one of the leading risk factors for lung cancer. The scarce evidence for associations with other mortality causes originates mostly fro ...
DOI:
10.1016/j.envint.2019.05.059

2. Associations between seasonal temperature and dementia-associated hospitalizations in New England

Author:
Schwartz, Joel D.,   et al.   ; Wei, Yaguang; Wang, Yan; Lin, Cheng-Kuan; Yin, Kanhua; Yang, Jiabei; Shi, Liuhua; Li, Longxiang; Zanobetti, Antonella;     Show all 9 Authors
Source:
Environment international 2019 v.126 pp. 228-233
ISSN:
0160-4120
Subject:
adverse effects; climate change; confidence interval; dementia; elderly; hospitals; models; risk; satellites; summer; temperature; winter; New England region
Abstract:
... Human-induced climate change has accelerated in recent decades, causing adverse health effects. However, the impact of the changing climate on neurological disorders in the older population is not well understood. We applied time-varying Cox proportional hazards models to estimate the associations between hospital admissions for dementia and the mean and variability of summer and winter temperatur ...
DOI:
10.1016/j.envint.2018.12.054

3. The association between short and long-term exposure to PM2.5 and temperature and hospital admissions in New England and the synergistic effect of the short-term exposures

Author:
Schwartz, Joel D.,   et al.   ; Yitshak-Sade, Maayan; Bobb, Jennifer F.; Kloog, Itai; Zanobetti, Antonella;     Show all 5 Authors
Source:
The Science of the total environment 2018 v.639 pp. 868-875
ISSN:
0048-9697
Subject:
adults; chronic exposure; heat; hospitals; long term effects; models; morbidity; particulates; satellites; stroke; synergism; temperature; New England region
Abstract:
... Particulate matter < 2.5 μm in diameter (PM2.5) and heat are strong predictors of morbidity, yet few studies have examined the effects of long-term exposures on non-fatal events, or assessed the short and long-term effect on health simultaneously.We jointly investigated the association of short and long-term exposures to PM2.5 and temperature with hospital admissions, and explored the modification ...
DOI:
10.1016/j.scitotenv.2018.05.181

4. Accounting for adaptation and intensity in projecting heat wave-related mortality

Author:
Schwartz, Joel D.,   et al.   ; Wang, Yan; Nordio, Francesco; Nairn, John; Zanobetti, Antonella;     Show all 5 Authors
Source:
Environmental research 2018 v.161 pp. 464-471
ISSN:
0013-9351
Subject:
cities; data collection; heat; models; mortality; people; summer; temperature; time series analysis; Western United States
Abstract:
... How adaptation and intensity of heat waves affect heat wave-related mortality is unclear, making health projections difficult.We estimated the effect of heat waves, the effect of the intensity of heat waves, and adaptation on mortality in 209 U.S. cities with 168 million people during 1962–2006. We improved the standard time-series models by incorporating the intensity of heat waves using excess h ...
DOI:
10.1016/j.envres.2017.11.049

5. Short-term exposure to ambient air pollution and circulating biomarkers of endothelial cell activation: The Framingham Heart Study

Author:
Schwartz, Joel D.,   et al.   ; Li, Wenyuan; Dorans, Kirsten S.; Wilker, Elissa H.; Rice, Mary B.; Ljungman, Petter L.; Coull, Brent A.; Koutrakis, Petros; Gold, Diane R.; Keaney,, John F.; Vasan, Ramachandran S.; Benjamin, Emelia J.; Mittleman, Murray A.;     Show all 13 Authors
Source:
Environmental research 2019 v.171 pp. 36-43
ISSN:
0013-9351
Subject:
acute exposure; air pollution; biomarkers; carbon; chemokine CCL2; demographic statistics; endothelial cells; inflammation; intercellular adhesion molecule-1; interleukin-18; lifestyle; ligands; models; monitoring; nitrogen oxides; ozone; particulates; phospholipase A2; pollutants; progeny; regression analysis; socioeconomic status; sulfates; women
Abstract:
... Short-term exposure to air pollution has been associated with cardiovascular events, potentially by promoting endothelial cell activation and inflammation. A few large-scale studies have examined the associations and have had mixed results.We included 3820 non-current smoking participants (mean age 56 years, 54% women) from the Framingham Offspring cohort examinations 7 (1998–2001) and 8 (2005–200 ...
DOI:
10.1016/j.envres.2018.10.027

6. Acute effects of fine particulate matter constituents on mortality: A systematic review and meta-regression analysis

Author:
Schwartz, Joel D.,   et al.   ; Achilleos, Souzana; Kioumourtzoglou, Marianthi-Anna; Wu, Chih-Da; Koutrakis, Petros; Papatheodorou, Stefania I.;     Show all 6 Authors
Source:
Environment international 2017
ISSN:
0160-4120
Subject:
acute effects; acute exposure; air temperature; carbon; combustion; databases; elderly; epidemiological studies; health effects assessments; hydroxyl radicals; meta-analysis; models; mortality; particulates; population density; potassium; regression analysis; risk; risk estimate; systematic review; vegetation
Abstract:
... The link between PM2.5 exposure and adverse health outcomes is well documented from studies across the world. However, the reported effect estimates vary across studies, locations and constituents. We aimed to conduct a meta-analysis on associations between short-term exposure to PM2.5 constituents and mortality using city-specific estimates, and explore factors that may explain some of the observ ...
DOI:
10.1016/j.envint.2017.09.010

7. Air pollution, land use, and complications of pregnancy

Author:
Schwartz, Joel D.,   et al.   ; Choe, Seung-Ah; Kauderer, Sophie; Eliot, Melissa N.; Glazer, Kimberly B.; Kingsley, Samantha L.; Carlson, Lynn; Awad, Yara A.; Savitz, David A.; Wellenius, Gregory A.;     Show all 10 Authors
Source:
The Science of the total environment 2018 v.645 pp. 1057-1064
ISSN:
0048-9697
Subject:
air pollution; carbon; coasts; freshwater; gestational diabetes; green infrastructure; hospitals; human health; hypertension; land use; models; particulates; pre-eclampsia; pregnancy; regression analysis; remote sensing; risk; roads; women; Rhode Island
Abstract:
... Mounting evidence suggests that the natural and built environment can affect human health, but relatively few studies have considered links between features of the residential natural and built environment other than air pollution and complications of pregnancy.To quantify the impact of features of the maternal residential natural and built environments on risk of gestational diabetes mellitus (GD ...
DOI:
10.1016/j.scitotenv.2018.07.237

8. Indoor black carbon and biomarkers of systemic inflammation and endothelial activation in COPD patients

Author:
Schwartz, Joel D.,   et al.   ; Garshick, Eric; Grady, Stephanie T.; Hart, Jaime E.; Coull, Brent A.; Laden, Francine; Moy, Marilyn L.; Koutrakis, Petros;     Show all 8 Authors
Source:
Environmental research 2018 v.165 pp. 358-364
ISSN:
0013-9351
Subject:
C-reactive protein; adhesion; ambient temperature; biomarkers; body mass index; carbon; diabetes; heart diseases; inflammation; interleukin-6; patients; people; reflectance; regression analysis; relative humidity; respiratory tract diseases
Abstract:
... Evidence linking traffic-related particle exposure to systemic effects in chronic obstructive lung disease (COPD) patients is limited.Assess relationships between indoor black carbon (BC), a tracer of traffic-related particles, and plasma biomarkers of systemic inflammation and endothelial activation.BC was measured by reflectance in fine particle samples over a mean of 7.6 days in homes of 85 COP ...
DOI:
10.1016/j.envres.2018.05.010

9. Recent exposure to particle radioactivity and biomarkers of oxidative stress and inflammation: The Framingham Heart Study

Author:
Schwartz, Joel D.,   et al.   ; Li, Wenyuan; Nyhan, Marguerite M.; Wilker, Elissa H.; Vieira, Carolina L.Z.; Lin, Honghuang; Gold, Diane R.; Coull, Brent A.; Aba, Abdulaziz Mansour; Benjamin, Emelia J.; Vasan, Ramachandran S.; Koutrakis, Petros; Mittleman, Murray A.;     Show all 13 Authors
Source:
Environment international 2018 v.121 pp. 1210-1216
ISSN:
0160-4120
Subject:
C-reactive protein; aerosols; air pollution; biomarkers; carbon; chemokine CCL2; demographic statistics; diabetes; fibrinogen; humans; inflammation; intercellular adhesion molecule-1; interleukin-6; ionizing radiation; meteorology; models; monitoring; myeloperoxidase; oxidative stress; particulates; progeny; radioactivity; regression analysis; tumor necrosis factor-alpha; women; Northeastern United States
Abstract:
... Decay products of radioactive materials may attach to ambient fine particles and form radioactive aerosol. Internal ionizing radiation source from inhaled radioactive aerosol may contribute to the fine particulate matter (PM2.5)-inflammation pathway. However, few studies in humans have examined the associations.To examine the associations between particle radioactivity and biomarkers of oxidative ...
DOI:
10.1016/j.envint.2018.10.039

10. Ambient air pollution, adipokines, and glucose homeostasis: The Framingham Heart Study

Author:
Schwartz, Joel D.,   et al.   ; Li, Wenyuan; Dorans, Kirsten S.; Wilker, Elissa H.; Rice, Mary B.; Kloog, Itai; Koutrakis, Petros; Coull, Brent A.; Gold, Diane R.; Meigs, James B.; Fox, Caroline S.; Mittleman, Murray A.;     Show all 12 Authors
Source:
Environment international 2018 v.111 pp. 14-22
ISSN:
0160-4120
Subject:
acute exposure; adiponectin; air pollutants; air pollution; blood glucose; carbon; demographic statistics; glucose; glycohemoglobin; homeostasis; insulin; insulin resistance; leptin; lifestyle; models; nitrogen oxides; noninsulin-dependent diabetes mellitus; obesity; ozone; particulates; progeny; regression analysis; resistin; roads; socioeconomic status; sulfates; women
Abstract:
... To examine associations of proximity to major roadways, sustained exposure to fine particulate matter (PM2.5), and acute exposure to ambient air pollutants with adipokines and measures of glucose homeostasis among participants living in the northeastern United States.We included 5958 participants from the Framingham Offspring cohort examination cycle 7 (1998–2001) and 8 (2005–2008) and Third Gener ...
DOI:
10.1016/j.envint.2017.11.010

11. Back-Extrapolating a Land Use Regression Model for Estimating Past Exposures to Traffic-Related Air Pollution

Author:
Schwartz, Joel D.,   et al.   ; Levy, Ilan; Levin, Noam; Yuval,; Kark, Jeremy D.;     Show all 5 Authors
Source:
Environmental Science & Technology 2015 v.49 no.6 pp. 3603-3610
ISSN:
1520-5851
Subject:
air pollution; air quality; emissions; land use; models; monitoring; prediction; regression analysis; spatial data; topographic maps; Israel
Abstract:
... Land use regression (LUR) models rely on air pollutant measurements for their development, and are therefore limited to recent periods where such measurements are available. Here we propose an approach to overcome this gap and calculate LUR models several decades before measurements were available. We first developed a LUR model for NOₓ using annual averages of NOₓ at all available air quality mon ...
DOI:
10.1021/es505707e

12. Impacts of the Mitochondrial Genome on the Relationship of Long-Term Ambient Fine Particle Exposure with Blood DNA Methylation Age

Author:
Schwartz, Joel D.,   et al.   ; Nwanaji-Enwerem, Jamaji C.; Colicino, Elena; Dai, Lingzhen; Cayir, Akin; Sanchez-Guerra, Marco; Laue, Hannah E.; Nguyen, Vy T.; Di, Qian; Just, Allan C.; Hou, Lifang; Vokonas, Pantel; Coull, Brent A.; Weisskopf, Marc G.; Baccarelli, Andrea A.;     Show all 15 Authors
Source:
Environmental science & technology 2017 v.51 no.14 pp. 8185-8195
ISSN:
1520-5851
Subject:
DNA methylation; blood; blood sampling; environmental science; genetic markers; mitochondrial DNA; mitochondrial genome; models; particulates
Abstract:
... The mitochondrial genome has long been implicated in age-related disease, but no studies have examined its role in the relationship of long-term fine particle (PM₂.₅) exposure and DNA methylation age (DNAm-age)—a novel measure of biological age. In this analysis based on 940 observations between 2000 and 2011 from 552 Normative Aging Study participants, we determined the roles of mitochondrial DNA ...
DOI:
10.1021/acs.est.7b02409
CHORUS:
10.1021/acs.est.7b02409