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- van Riel, D., et al. Show all 5 Authors
- Journal of comparative pathology 2014 v.151 no.1 pp. 83-112
- Influenza A virus; Primates; Severe acute respiratory syndrome coronavirus; animal models; bronchioles; cats; ferrets; fibrosis; giant cells; hosts; human diseases; human population; humans; inflammation; influenza; laboratory animals; morbidity; mortality; necrosis; pandemic; pathogenesis; pneumonia; pulmonary alveoli; viruses
- ... Respiratory viruses that emerge in the human population may cause high morbidity and mortality, as well as concern about pandemic spread. Examples are severe acute respiratory syndrome coronavirus (SARS-CoV) and novel variants of influenza A virus, such as H5N1 and pandemic H1N1. Different animal models are used to develop therapeutic and preventive measures against such viruses, but it is not cle ...
- van Riel, D., et al. Show all 8 Authors
- Anas platyrhynchos; Influenza A virus; Larus delawarensis; air sacs; animal pathology; avian influenza; body weight changes; cloaca; ducks; immunohistochemistry; intestinal mucosa; lungs; pathogenicity; pharynx; pneumonia; reverse transcriptase polymerase chain reaction; signs and symptoms (animals and humans); wild birds
- ... Many subtypes of low-pathogenicity avian influenza (LPAI) virus circulate in wild bird reservoirs, but their prevalence may vary among species. We aimed to compare by real-time reverse-transcriptase polymerase chain reaction, virus isolation, histology, and immunohistochemistry the distribution and pathogenicity of 2 such subtypes of markedly different origins in Mallard ducks (Anas platyrhynchos) ...
- Van Riel, D., et al. Show all 7 Authors
- chickens; avian influenza; Influenza A virus; pathogenicity; infection; disease outbreaks; histopathology; immunohistochemistry; viral antigens; tissue tropism; wattles; endothelial cells; Netherlands
- ... The largest recorded outbreak of highly pathogenic avian influenza virus of the subtype H7N7 occurred in the Netherlands in 2003. We describe the immunohistochemical and histopathologic findings of 3 chickens naturally infected during this outbreak. Influenza virus antigen occurred in endothelial cells and mononuclear cells of all tissues examined and occurred in parenchymal cells of heart, lung, ...