Author: "Borhan, Babak" / Text Availability: Full Text

Author:: Borhan, Babak, et al. ; Ashtekar, Kumar Dilip; Ding, Xinliang; Toma, Edmond; Sheng, Wei; Gholami, Hadi; Rahn, Christopher; Reed, Paul; Show all 8 Authors
Source:: Organic letters 2016 v.18 no.16 pp. 3976-3979
ISSN:: 1523-7052
Subject:: chemical bonding; chemical structure; cycloaddition reactions; diastereoselective synthesis; organic compounds; stereoselectivity
Abstract:: ... Utilizing two robust C–C bond-forming reactions, the Baylis–Hillman reaction and the Diels–Alder reaction, we report a highly enantio-, regio-, and diastereoselective synthesis of hexahydro-2H-chromenes via two sequential [4 + 2] cycloadditions. These tandem and formal cycloadditions have also been performed as a “one-pot” sequence to access the corresponding heterocycles constituting up to five c ...
DOI:: 10.1021/acs.orglett.6b01742
PubMed:: 27487461
PubMed Central:: PMC5342895
: http://dx.doi.org/10.1021%2Facs.orglett.6b01742

Author:: Borhan, Babak, et al. ; Ashtekar, Kumar Dilip; Vetticatt, Mathew; Yousefi, Roozbeh; Jackson, James E.; Show all 5 Authors
Source:: Journal of the American Chemical Society 2016 v.138 no.26 pp. 8114-8119
ISSN:: 1520-5126
Subject:: alkenes; chemical interactions; enantiomers; isotopes; spectroscopy; stereoisomerism
Abstract:: ... Emerging work on organocatalytic enantioselective halocyclizations naturally draws on conditions where both new bonds must be formed under delicate control, the reaction regime where the concerted nature of the AdE3 mechanism is of greatest importance. Without assistance, many simple alkene substrates react slowly or not at all with conventional halenium donors under synthetically relevant reactio ...
DOI:: 10.1021/jacs.6b02877
PubMed:: 27284808
PubMed Central:: PMC5340197
: http://dx.doi.org/10.1021%2Fjacs.6b02877

Author:: Borhan, Babak, et al. ; Yapici, Ipek; Lee, Kin Sing Stephen; Berbasova, Tetyana; Nosrati, Meisam; Jia, Xiaofei; Vasileiou, Chrysoula; Wang, Wenjing; Santos, Elizabeth M.; Geiger, James H.; Show all 10 Authors
Source:: Journal of the American Chemical Society 2015 v.137 no.3 pp. 1073-1080
ISSN:: 1520-5126
Subject:: binding proteins; dyes; fluorescence; fluorescent proteins; mutants; mutation; pH; retinoic acid; spectroscopy
Abstract:: ... Protein reengineering of cellular retinoic acid binding protein II (CRABPII) has yielded a genetically addressable system, capable of binding a profluorophoric chromophore that results in fluorescent protein/chromophore complexes. These complexes exhibit far-red emission, with high quantum efficiencies and brightness and also exhibit excellent pH stability spanning the range of 2–11. In the course ...
DOI:: 10.1021/ja506376j
PubMed:: 25534273
PubMed Central:: PMC4311949
: http://dx.doi.org/10.1021%2Fja506376j

Author:: Borhan, Babak, et al. ; Wang, Wenjing; Nossoni, Zahra; Berbasova, Tetyana; Watson, Camille T.; Yapici, Ipek; Lee, Kin Sing Stephen; Vasileiou, Chrysoula; Geiger, James H.; Show all 9 Authors
Source:: Science 2012 v.338 no.6112 pp. 1340-1343
ISSN:: 0036-8075
Subject:: absorbance; absorption; animals; microorganisms; mutagenesis; phototaxis; protein binding; retinol-binding protein; rhodopsin; schiff bases; visual perception; wavelengths
Abstract:: ... Seeing the Light Rhodopsins respond to a range of electromagnetic radiation—allowing visual perception over a broad wavelength range in animals and facilitating light-driven ion transport and phototaxis in microorganisms. All rhodopsins contain an embedded retinal chromophore in which absorbance is tuned by the protein environment. To gain insight into how the protein tunes absorbance, Wang et al. ...
DOI:: 10.1126/science.1226135
PubMed:: 23224553
PubMed Central:: PMC4046837
: http://dx.doi.org/10.1126/science.1226135

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