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- Chen, You-Peng, et al. Show all 13 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.28 pp. 11324-11329
- fluorescence microscopy; genetic variation; gestational diabetes; glucose tolerance; glycemic control; glycosylation; hemoglobin; hypomagnesemia; insulin; insulin resistance; magnesium; noninsulin-dependent diabetes mellitus; phosphatidylinositol 3-kinase; pregnancy; pregnant women; risk factors; signal transduction; single nucleotide polymorphism
- ... Hypomagnesemia affects insulin resistance and is a risk factor for diabetes mellitus type 2 (DM2) and gestational diabetes mellitus (GDM). Two single nucleotide polymorphisms (SNPs) in the epithelial magnesium channel TRPM6 (V ¹³⁹³I, K ¹⁵⁸⁴E) were predicted to confer susceptibility for DM2. Here, we show using patch clamp analysis and total internal reflection fluorescence microscopy, that insulin ...
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