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- Kandil, Rima, et al. Show all 12 Authors
- Journal of controlled release 2018 v.276 pp. 50-58
- cations; composite polymers; cultured cells; flow cytometry; gene silencing; lungs; melittin; messenger RNA; mice; microscopy; plasmids; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; small interfering RNA; transfection
- ... The block copolymer VIPER (virus-inspired polymer for endosomal release) has been reported to be a promising novel delivery system of DNA plasmids both in vitro and in vivo. VIPER is comprised of a polycation segment for condensation of nucleic acids as well as a pH-sensitive segment that exposes the membrane lytic peptide melittin in acidic environments to facilitate endosomal escape. The objecti ...
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