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- Paumann-Page, Martina, et al. Show all 6 Authors
- Archives of biochemistry and biophysics 2013 v.539 no.1 pp. 51-62
- heme; humans; hydrogen peroxide; iron; methionine; myeloperoxidase; neutrophils; oxidants; oxidation; peroxidase; phagosomes; polypeptides; thermal stability
- ... Human myeloperoxidase (MPO) uses hydrogen peroxide generated by the oxidative burst of neutrophils to produce an array of antimicrobial oxidants. During this process MPO is irreversibly inactivated. This study focused on the unknown role of hydrogen peroxide in this process. When treated with low concentrations of H₂O₂ in the absence of reducing substrates, there was a rapid loss of up to 35% of i ...
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