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- Yang, Hongwei, et al. Show all 10 Authors
- Cell 2013 v.155 pp. 1154-1165
- Alzheimer disease; Cannabis sativa; adverse effects; animals; arachidonic acid; brain; fearfulness; gene expression regulation; glutamic acid; medical treatment; memory; neurodegenerative diseases; neurons; prostaglandin synthase; prostaglandins; synapse
- ... Marijuana has been used for thousands of years as a treatment for medical conditions. However, untoward side effects limit its medical value. Here, we show that synaptic and cognitive impairments following repeated exposure to Δ9-tetrahydrocannabinol (Δ9-THC) are associated with the induction of cyclooxygenase-2 (COX-2), an inducible enzyme that converts arachidonic acid to prostanoids in the brai ...
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