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1. Microscale Mass Spectrometry Analysis of Extracellular Metabolites in Live Multicellular Tumor Spheroids

Author:
Yang, Zhibo,   et al.   ; Sun, Mei; Tian, Xiang;     Show all 3 Authors
Source:
Analytical chemistry 2017 v.89 no.17 pp. 9069-9076
ISSN:
1520-6882
Subject:
antineoplastic agents; biomarkers; cell communication; drug resistance; ionization; lipids; mass spectrometry; metabolites; metastasis; neoplasm cells; neoplasms; silica
Abstract:
... Extracellular compounds in tumors play critical roles in intercellular communication, tumor proliferation, and cancer cell metastasis. However, the lack of appropriate techniques leads to limited studies of extracellular metabolite. Here, we introduced a microscale collection device, the Micro-funnel, fabricated from biocompatible fused silica capillary. With a small probe size (∼25 μm), the Micro ...
DOI:
10.1021/acs.analchem.7b01746
PubMed:
28753268
PubMed Central:
PMC5912160

2. Using Dicationic Ion-Pairing Compounds To Enhance the Single Cell Mass Spectrometry Analysis Using the Single-Probe: A Microscale Sampling and Ionization Device

Author:
Yang, Zhibo,   et al.   ; Pan, Ning; Rao, Wei; Standke, Shawna J.;     Show all 4 Authors
Source:
Analytical chemistry 2016 v.88 no.13 pp. 6812-6819
ISSN:
1520-6882
Subject:
ionization; ions; mass spectrometry; metabolites; solvents
Abstract:
... A unique mass spectrometry (MS) method has been developed to determine the negatively charged species in live single cells using the positive ionization mode. The method utilizes dicationic ion-pairing compounds through the miniaturized multifunctional device, the single-probe, for reactive MS analysis of live single cells under ambient conditions. In this study, two dicationic reagents, 1,5-penta ...
DOI:
10.1021/acs.analchem.6b01284
PubMed:
27239862
PubMed Central:
PMC4935574