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1. Circular RNA circMTO1 suppresses bladder cancer metastasis by sponging miR-221 and inhibiting epithelial-to-mesenchymal transition

Author:
Wan, Bo,   et al.   ; Li, Yixiao; Liu, Lei; Zhou, Lei; Zeng, Qing;     Show all 5 Authors
Source:
Biochemical and biophysical research communications 2019 v.508 no.4 pp. 991-996
ISSN:
0006-291X
Subject:
biomarkers; cell proliferation; circular RNA; death; humans; metastasis; neoplasm cells; oncogenes; patients; therapeutics; urinary bladder neoplasms
Abstract:
... Bladder cancer remains a leading cause of cancer-related death because of its distant metastasis and high recurrence rates. Deregulation of circular RNAs (circRNAs) can act either as tumor suppressors or oncogenes to control cell proliferation, migration, and metastasis. The role of circMTO1 in bladder cancer remain unknown. In this study, we investigated whether circMTO1 could use as a biomarker ...
DOI:
10.1016/j.bbrc.2018.12.046

2. Efficiency of Extreme Gradient Boosting for Imbalanced Land Cover Classification Using an Extended Margin and Disagreement Performance

Author:
Wan, Bo,   et al.   ; Sun, Fei; Wang, Run; Su, Yanjun; Guo, Qinghua; Huang, Youxin; Wu, Xincai;     Show all 7 Authors
Source:
ISPRS international journal of geo-information 2019 v.8 no.7
ISSN:
2220-9964
Subject:
land cover; learning; model validation; remote sensing; uncertainty; vegetation types
Abstract:
... Imbalanced learning is a methodological challenge in remote sensing communities, especially in complex areas where the spectral similarity exists between land covers. Obtaining high-confidence classification results for imbalanced class issues is highly important in practice. In this paper, extreme gradient boosting (XGB), a novel tree-based ensemble system, is employed to classify the land cover ...
DOI:
10.3390/ijgi8070315

3. Porcine FcγRIIb mediated PRRSV ADE infection through inhibiting IFN-β by cytoplasmic inhibitory signal transduction

Author:
Wan, Bo,   et al.   ; Chen, Xinxin; Li, Yujia; Pang, Mimi; Chen, Hui; Nie, Xueke; Pan, Yue; Qiao, Songlin; Bao, Dengke;     Show all 9 Authors
Source:
International journal of biological macromolecules 2019 v.138 pp. 198-206
ISSN:
0141-8130
Subject:
Porcine reproductive and respiratory syndrome virus; cytoplasm; immunologic receptors; interferon-beta; mutants; porcine reproductive and respiratory syndrome; signal transduction; swine; tyrosine; vaccine development; vaccines
Abstract:
... Antibody-dependent enhancement (ADE) in porcine reproductive and respiratory syndrome virus (PRRSV) infection is a significant obstacle to the development of effective vaccines for controlling PRRS. Our previous results have demonstrated that porcine FcγRIIb (poFcγRIIb) play an important role in mediating ADE of PRRSV infection in vitro. However, the underlying mechanisms involved in poFcγRIIb med ...
DOI:
10.1016/j.ijbiomac.2019.07.005

4. A holistic approach to aligning geospatial data with multidimensional similarity measuring

Author:
Wan, Bo,   et al.   ; Yu, Li; Qiu, Peiyuan; Liu, Xiliang; Lu, Feng;     Show all 5 Authors
Source:
International journal of digital earth 2018 v.11 no.8 pp. 845-862
ISSN:
1753-8955
Subject:
computer software; data analysis; geographical variation; spatial data
Abstract:
... Semantically aligning the heterogeneous geospatial datasets (GDs) produced by different organizations demands efficient similarity matching methods. However, the strategies employed to align the schema (concept and property) and instances are usually not reusable, and the effects of unbalanced information tend to be neglected in GD alignment. To solve this problem, a holistic approach is presented ...
DOI:
10.1080/17538947.2017.1359688

5. Lorf9 deletion significantly eliminated lymphoid organ atrophy induced by meq-deleted very virulent Marek’s disease virus

Author:
Wan, Bo,   et al.   ; Sun, Aijun; Luo, Jun; Du, Yongkun; Wang, Xiangru; Weng, Haoyu; Cao, Xinru; Zhang, Tianlu; Chai, Shujun; Zhao, Dong; Xing, Guangxu; Zhuang, Guoqing; Zhang, Gaiping;     Show all 13 Authors
Source:
Veterinary microbiology 2019 v.235 pp. 164-169
ISSN:
0378-1135
Subject:
Mardivirus; T-lymphocytes; atrophy; chickens; genes; immunity; in vitro studies; live vaccines; lymphatic system; lymphoma; mutants; virulence; virulent strains; viruses
Abstract:
... Marek’s disease virus (MDV) is a highly contagious alphaherpesvirus that causes rapid onset of T cell lymphomas in chickens. MDV continues to break through vaccinal immunity due to the emergence of highly virulent field strains. Earlier studies revealed that deletion of the meq gene from MDV results in attenuated vaccines that protect against disease when chickens are infected with highly virulent ...
DOI:
10.1016/j.vetmic.2019.06.020

6. A Parallel-Computing Approach for Vector Road-Network Matching Using GPU Architecture

Author:
Wan, Bo,   et al.   ; Yang, Lin; Zhou, Shunping; Wang, Run; Wang, Dezhi; Zhen, Wenjie;     Show all 6 Authors
Source:
ISPRS international journal of geo-information 2018 v.7 no.12
ISSN:
2220-9964
Subject:
algorithms; data collection; roads
Abstract:
... The road-network matching method is an effective tool for map integration, fusion, and update. Due to the complexity of road networks in the real world, matching methods often contain a series of complicated processes to identify homonymous roads and deal with their intricate relationship. However, traditional road-network matching algorithms, which are mainly central processing unit (CPU)-based a ...
DOI:
10.3390/ijgi7120472

7. Late Paleozoic to early Triassic multiple roll-back and oroclinal bending of the Mongolia collage in Central Asia

Author:
Wan, Bo,   et al.   ; Xiao, Wenjiao; Windley, Brian F.; Han, Chunming; Liu, Wei; Zhang, Ji'en; Ao, Songjian; Zhang, Zhiyong; Song, Dongfang;     Show all 9 Authors
Source:
Earth-science reviews 2018 v.186 pp. 94-128
ISSN:
0012-8252
Subject:
Carboniferous period; Chara; Permian period; Triassic period; lakes; mechanics; models; oceans; tectonics; China; Kazakhstan; Mongolia; Siberia
Abstract:
... The architecture and mechanics of an orogen can be understood in terms of a system of collages that are characterized by a complex assemblage of multiple components, but the fundamental paleogeographic framework and the tectonic relationships between the different components are often insufficiently defined, because of unavailable data. The Central Asian Orogenic Belt (CAOB) provides an ideal oppo ...
DOI:
10.1016/j.earscirev.2017.09.020

8. Genomic analysis of a recombinant NADC30-like porcine reproductive and respiratory syndrome virus in china

Author:
Wan, Bo,   et al.   ; Wang, Lin-jian; Guo, Zhenhua; Qiao, Songlin; Li, Rui; Xie, Sha; Chen, Xin-xin; Zhang, Gaiping;     Show all 8 Authors
Source:
Virus genes 2018 v.54 no.1 pp. 86-97
ISSN:
0920-8569
Subject:
Porcine reproductive and respiratory syndrome virus; amino acids; epidemiology; genetic similarity; genome; genomics; glycosylation; macrophages; mutation; nucleotide sequences; phylogeny; swine; vaccines; viral nonstructural proteins; China
Abstract:
... Recently, NADC30-like porcine reproductive and respiratory syndrome viruses (PRRSVs), which are genetically similar to the NADC30 strain isolated in the United States of America in 2008, have become prevalent in China. Here, a novel variant PRRSV strain named HNhx was successfully isolated on porcine alveolar macrophages from Henan province and the full-length genome sequence was determined. Phylo ...
DOI:
10.1007/s11262-017-1516-1

9. PKM2 knockdown influences SREBP activation and lipid synthesis in bovine mammary-gland epithelial MAC-T cells

Author:
Wan, Bo,   et al.   ; Su, Bing-Qian; Han, Ying-Qian; Fan, Shuang-Shuang; Ming, Sheng-Li; Lu, Wei-Fei; Chu, Bei-Bei; Yang, Guo-Yu; Wang, Jiang;     Show all 9 Authors
Source:
Biotechnology letters 2018 v.40 no.4 pp. 641-648
ISSN:
0141-5492
Subject:
cattle; cell growth; enzymes; epithelial cells; epithelium; glycolysis; lipid metabolism; messenger RNA; protein synthesis; sterols
Abstract:
... OBJECTIVE: The purpose of the article is to evaluate the changes in lipid metabolism in bovine mammary-gland epithelial MAC-T cells after PKM2 knockdown. RESULTS: MAC-T cells stably expressing low levels of PKM2 were established with lentivirus-mediated small hairpin RNA. Although the knockdown of PKM2 had no effect on MAC-T cell growth, the reduced expression of PKM2 attenuated the mRNA and prote ...
DOI:
10.1007/s10529-018-2518-3

10. Maintenance of cyclic GMP–AMP homeostasis by ENPP1 is involved in pseudorabies virus infection

Author:
Wan, Bo,   et al.   ; Wang, Jiang; Lu, Shao-Fang; Ming, Sheng-Li; Li, Guo-Li; Su, Bing-Qian; Liu, Jiao-Yang; Wei, Yu-Shuang; Yang, Guo-Yu; Chu, Bei-Bei;     Show all 10 Authors
Source:
Molecular immunology 2018 v.95 pp. 56-63
ISSN:
0161-5890
Subject:
transcription factor NF-kappa B; Suid alphaherpesvirus 1; messenger RNA; secretion; muscles; DNA; homeostasis; phosphorylation; interferon-beta; rodents; swine
Abstract:
... In a previous study, we demonstrated that porcine cyclic GMP–AMP (cGAMP) synthase (cGAS) catalyzes cGAMP production and is an important DNA sensor for the pseudorabies virus (PRV)-induced activation of interferon β (IFN-β). Ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) has recently been identified as the hydrolase of cGAMP in rodents, but its role in porcine cells is not clear. Our re ...
DOI:
10.1016/j.molimm.2018.01.008

11. Optimized culture medium for the production of flavonoids from Orostachys cartilaginea V.N. Boriss. callus cultures Plant

Author:
Zhang, Wan Bo,   et al.   ; Piao, Xuan Chun; Li, Jin Rong; Jin, Ying Hua; Lian, Mei Lan;     Show all 5 Authors
Source:
In vitro cellular & developmental biology 2017 v.53 no.1 pp. 1-11
ISSN:
1054-5476
Subject:
Orostachys; ammonium; benzyladenine; callus; callus culture; culture media; epicatechin; in vitro studies; naphthaleneacetic acid; phosphates; quercetin; sucrose
Abstract:
... The optimal culture medium for the production of flavonoid compounds from Orostachys cartilaginea V. N. Boriss. calluses was studied. In callus cultures of O. cartilaginea, the flavonoid monomer content, in decreasing order was kaempferol-3-O-rutinoside (Kp-3-rut), quercetin 3-O-glucoside (Qc-3-glc), epicatechin gallate (Ecg), kaempferide (Ke), and quercetin (Qc). The results of the uniform design ...
DOI:
10.1007/s11627-017-9799-4

12. Porcine 2′, 5′-oligoadenylate synthetase 2 inhibits porcine reproductive and respiratory syndrome virus replication in vitro

Author:
Wan, Bo,   et al.   ; Zhao, Mengmeng; Li, Huawei; He, Jian; Chen, Xinxin; Wang, Linjian; Wang, Yinbiao; Xie, Sha; Qiao, Songlin; Zhang, Gaiping;     Show all 10 Authors
Source:
Microbial pathogenesis 2017 v.111 pp. 14-21
ISSN:
0882-4010
Subject:
Porcine reproductive and respiratory syndrome virus; antiviral properties; genes; industry; interferons; livestock production; macrophages; pathogens; retinoic acid; ribonucleases; swine; vaccines; virus replication; viruses
Abstract:
... Porcine reproductive and respiratory syndrome virus (PRRSV) is acknowledged a fulminating infectious pathogen affecting the pig farming industry, and current vaccines and drugs could hardly inhibit this virus. The 2′, 5′-oligoadenylate synthetase (OASs) have antiviral activities, but the role(s) played by porcine OAS2 in protection against PRRSV infection are unknown. Here we found that endogenous ...
DOI:
10.1016/j.micpath.2017.08.011

13. First Report of Toxoplasma gondii Infection in Common Quails (Coturnix coturnix) Intended for Human Consumption in Three Provinces of Northeastern China

Author:
Chi, Wan-Bo,   et al.   ; Cong, Wei; Sun, Wu-Wen; Shan, Xiao-Feng; Kang, Yuan-Huan; Meng, Qing-Feng; Qian, Ai-Dong;     Show all 7 Authors
Source:
Vector borne and zoonotic diseases 2017 v.17 no.5 pp. 351-353
ISSN:
1557-7759
Subject:
Coturnix coturnix; Toxoplasma gondii; agglutination tests; cities; females; humans; males; medicine; public health; quails; seroprevalence; surveys; toxoplasmosis; China
Abstract:
... Common quails are nutritious food and are also used as medicine in some parts of the world. Until now, no information on Toxoplasma gondii infection in common quails intended for human consumption in China is available. Therefore, this study was carried out to determine the prevalence of T. gondii infection in common quails in six cities from Shandong, Liaoning, and Jilin provinces, China. Out of ...
DOI:
10.1089/vbz.2016.2078

14. Cell suspension culture of Orostachys cartilaginous in bioreactor systems for bioactive compound production and evaluation of their antioxidant properties

Author:
Zhang, Wan-Bo,   et al.   ; Piao, Xuan-Chun; Jiang, Jun; Jin, Ying-Hua; Park, Pyo-Jam; Kim, Seong-Eun; Lian, Mei-Lan;     Show all 7 Authors
Source:
Acta physiologiae plantarum 2017 v.39 no.3 pp. 70
ISSN:
0137-5881
Subject:
2,2-diphenyl-1-picrylhydrazyl; Orostachys; air; antioxidant activity; bioactive compounds; biomass production; bioreactors; cell growth; cell suspension culture; epicatechin; polysaccharides; quercetin
Abstract:
... For selecting a suitable culture period during bioreactor culture of Orostachys cartilaginous cells, the kinetics of cell biomass and bioactive compound accumulation were investigated. Cell biomass accumulation had a typical lag phase from 0 to 5 days, an exponential phase from 10 to 25 days, and an obvious declining phase from 25 to 30 days. Total polysaccharide and phenolic accumulation was sync ...
DOI:
10.1007/s11738-017-2374-0

15. Pathogenic fungal elicitors enhance ginsenoside biosynthesis of adventitious roots in Panax quinquefolius during bioreactor culture

Author:
Zhang, Wan-Bo,   et al.   ; Yu, Yao; Li, Xi-Ying; Piao, Xuan-Chun; Jiang, Jun; Lian, Mei-Lan;     Show all 6 Authors
Source:
Industrial crops and products 2016 v.94 pp. 729-735
ISSN:
0926-6690
Subject:
Alternaria panax; Iliyonectria radicicola; Panax quinquefolius; adventitious roots; biomass; bioreactors; biosynthesis; culture media; elicitors; fungi; metabolites; nitric oxide; putrescine
Abstract:
... Fungi have been widely used as biotic elicitors to promote metabolite production of plant cell, tissue, and organ cultures. Alternaria panax Whetz. and Cylindrocarpon destructans (Zinss) Scholten are the main pathogenic fungi in ginseng cultivation. The present study used extracts of A. panax and C. destructans as elicitors to simulate adventitious roots (ARs) of Panax quinquefolius L. for improve ...
DOI:
10.1016/j.indcrop.2016.09.058

16. BRSK2 is a valosin-containing protein (VCP)-interacting protein that affects VCP functioning in endoplasmic reticulum-associated degradation

Author:
Wan, Bo,   et al.   ; Wang, Yingli; Zhou, Jun; Li, Ruwei; Yu, Long;     Show all 5 Authors
Source:
Biotechnology letters 2013 v.35 no.12 pp. 1983-1989
ISSN:
0141-5492
Subject:
AMP-activated protein kinase; cytosol; fluorescent antibody technique; protein degradation; proteins; serine; threonine
Abstract:
... Endoplasmic reticulum-associated protein degradation (ERAD) removes improperly-folded proteins from the ER membrane into the cytosol where they undergo proteasomal degradation. Valosin-containing protein (VCP)/p97 mediates in the extraction of ERAD substrates from the ER. BRSK2 (also known as SAD-A), a serine/threonine kinase of the AMP-activated protein kinase family affected VCP/p97 activity in ...
DOI:
10.1007/s10529-013-1295-2
PubMed:
23907667

17. Molecular dynamics study of carbon nanotube as a potential dual-functional inhibitor of HIV-1 integrase

Author:
Wan, Bo,   et al.   ; Zhang, Zhishun; Wang, Bingqiang; Yu, Long; Huang, Qiang;     Show all 5 Authors
Source:
Biochemical and biophysical research communications 2013 v.436 pp. 650-654
ISSN:
0006-291X
Subject:
DNA; Human immunodeficiency virus 1; carbon nanotubes; drug delivery systems; drug resistance; drugs; genome; humans; molecular dynamics; mutants; nanoparticles; physicochemical properties
Abstract:
... HIV-1 integrase (IN) plays an important role in integrating viral DNA into human genome, which has been considered as the drug target for anti-AIDS therapy. The appearance of drug-resistance mutants urgently requires novel inhibitors that act on non-active site of HIV-1 IN. Nanoparticles have such unique geometrical and chemical properties, which inspires us that nanoparticles like nanotubes may s ...
DOI:
10.1016/j.bbrc.2013.06.009

18. Two new diketopiperazines and a new glucosyl sesterterpene from Alternaria alternata, an endophytic fungi from Ceratostigma griffithii

Author:
Wan, Bo,   et al.   ; Guo, Da-Le; Zhao, Min; Xiao, Shi-Ji; Xia, Bing; Gu, Yu-Cheng; Ding, Li-Sheng; Zhou, Yan;     Show all 8 Authors
Source:
Phytochemistry letters 2015 v.14 pp. 260-264
ISSN:
1874-3900
Subject:
Alternaria alternata; Ceratostigma; culture media; diketopiperazines; endophytes; fungi; phytotoxicity; spectral analysis
Abstract:
... Two diketopiperazine derivatives, altenarizines A (1) and B (2), and a new glucosyl sesterterpene, 24-α-d-glucosyl-(−)-terpestacin (3), together with two known phytotoxic sesterterpenes, (−)-terpestacin (4) and fusaproliferin (5), were isolated from the fermentation broth of an endophytic fungus Alternaria alternata, which was obtained from the fresh root of Ceratostigma griffithii. Structures of ...
DOI:
10.1016/j.phytol.2015.10.024

19. Chemical constituents from Cremanthodium brunneo-pilosum S. W. Liu

Author:
Wan, Bo,   et al.   ; He, Zhi-Zhou; Ding, Li-Sheng; Xu, Rui-Hong; Peng, Shu-Lin; Liu, Hao-Huai; Zeng, Yuan;     Show all 7 Authors
Source:
Biochemical systematics and ecology 2015 v.61 pp. 118-120
ISSN:
0305-1978
Subject:
Asteraceae; chemical composition; chemotaxonomy; isoflavones; sesquiterpenoids; steroids
Abstract:
... Fourteen compounds were isolated from Cremanthodium brunneo-pilosum, including two steroids (1 and 14), five sesquiterpenoids (2–6), six flavonoids (7–12) and one isoflavone (13). Graveolide (2) was obtained from a plant for the first time. 5,7-Dihydroxy-3,6,3′,4′-tetramethoxy-flavone (9), centaureidin (10) and tectoridin (13) have not been isolated from the family Compositae. The chemotaxonomic d ...
DOI:
10.1016/j.bse.2015.06.006

20. Induction of systemic resistance against tobacco mosaic virus by Ningnanmycin in tobacco

Author:
Wan, Bo,   et al.   ; Han, Yongguang; Luo, Yue; Qin, Shirong; Xi, Lei; Du, Linfang;     Show all 6 Authors
Source:
Pesticide biochemistry and physiology 2014 v.111 pp. 14-18
ISSN:
0048-3575
Subject:
Tobacco mosaic virus; antiviral agents; antiviral properties; coat proteins; genes; pathogenesis-related proteins; peroxidase; polymerization; signal transduction; superoxide dismutase; systemic acquired resistance; tobacco
Abstract:
... Ningnanmycin (NNM) is an antiviral agent firstly isolated from Strepcomces noursei var·xichangensisn. Studies have shown that NNM promotes PAL, POD and SOD activity and possesses antiviral activity against tobacco mosaic virus (TMV). In this study, our results demonstrated that NNM inhibited the polymerization process of TMV coat protein (TMV-CP) in vitro and promoted the systemic accumulation of ...
DOI:
10.1016/j.pestbp.2014.04.008