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1. Enhanced in vitro efficacy for inhibiting hypertrophic scar by bleomycin-loaded dissolving hyaluronic acid microneedles

Author:
Zhu, Jintao,   et al.   ; Xie, Ying; Wang, Hua; Mao, Jinzhu; Li, Yuce; Hussain, Mubashir; Zhu, Jinjin; Li, Yan; Zhang, Lianbin; Tao, Juan;     Show all 10 Authors
Source:
Journal of materials chemistry B 2019 v.7 no.42 pp. 6604-6611
ISSN:
2050-7518
Subject:
bioavailability; biocompatibility; fibroblasts; humans; hyaluronic acid; pain; patients; quality of life; secretion; skin diseases; solubility; strength (mechanics); swine; transforming growth factor beta 1
Abstract:
... Hypertrophic scarring is a widespread skin disorder that affects a patient's confidence and quality of life. Intralesional injection of bleomycin is one of the most commonly employed treatments for hypertrophic scars, which, however, always brings pain and requires long-term treatment. To overcome these limitations, new methods for bleomycin delivery enabling painlessness, self-administration, the ...
DOI:
10.1039/c9tb01449g

2. Segmental Janus nanoparticles of polymer composites

Author:
Zhu, Jintao,   et al.   ; WangThese authors contributed equally to the work., Ke; Li, Fan; Tian, Di; Xu, Jiangping; Liu, Yuanyuan; Hou, Zaiyan; Zhou, Huamin; Chen, Senbin; Yang, Zhenzhong;     Show all 10 Authors
Source:
Chemical communications 2019 v.55 no.56 pp. 8114-8117
ISSN:
1364-548X
Subject:
chemical reactions; ligands; nanoparticles; polymers
Abstract:
... We demonstrate a facile yet robust “plasma etching and grafting” strategy to prepare Janus nanoparticles (NPs) coated with binary polymer brushes on two different sides. The ratio of the two types of polymer ligands can be tailored by tuning the plasma etching power. ...
DOI:
10.1039/c9cc03067k

3. Upconverting Oil-Laden Hollow Mesoporous Silica Microcapsules for Anti-Stokes-Based Biophotonic Applications

Author:
Zhu, Jintao,   et al.   ; Lee, Hak-Lae; Park, Jung Hwan; Choe, Hyun-Seok; Lee, Myung-Soo; Park, Jeong-Min; Harada, Naoyuki; Sasaki, Yoichi; Yanai, Nobuhiro; Kimizuka, Nobuo; Bhang, Suk Ho; Kim, Jae-Hyuk;     Show all 12 Authors
Source:
ACS applied materials & interfaces 2019 v.11 no.30 pp. 26571-26580
ISSN:
1944-8252
Subject:
animal models; biophotonics; cytotoxicity; encapsulation; humans; image analysis; mesenchymal stromal cells; neoplasm cells; oils; photons; porous media; silica; stem cells
Abstract:
... A recyclable, aqueous phase functioning and biocompatible photon upconverting system is developed. Hollow mesoporous silica microcapsules (HMSMs) with ordered radial mesochannels were employed, for the first time, as vehicles for the post-encapsulation of oil phase triplet–triplet annihilation upconversion (TTA-UC), with the capability of homogeneous suspension in water. In-depth characterization ...
DOI:
10.1021/acsami.9b06620

4. Self-adhesive photothermal hydrogel films for solar-light assisted wound healing

Author:
Zhu, Jintao,   et al.   ; GaoThese authors contributed equally to this work., Yujie; Du, Hongyao; Xie, Zhanjun; Li, Miaomiao; Zhu, Jinjin; Xu, Jingwei; Zhang, Lianbin; Tao, Juan;     Show all 9 Authors
Source:
Journal of materials chemistry B 2019 v.7 no.23 pp. 3644-3651
ISSN:
2050-7518
Subject:
adhesion; angiogenesis; collagen; graphene oxide; heat; hydrogels; inflammation; irradiation; polymerization; solar radiation; temperature; tissue repair; transforming growth factor beta 1; vascular endothelial growth factor A
Abstract:
... Hydrogel-based dressings can provide a moist environment for wounds, and have been proven to be beneficial for wound healing. However, preparation of effective hydrogel dressings in a facile yet robust manner still remains a big challenge. Herein, a photo-initiated polymerization method is employed to develop a photothermal hydrogel film with self-adhesive properties for accelerated wound healing ...
DOI:
10.1039/c9tb00481e

5. Apoptotic cell-mimicking gold nanocages loaded with LXR agonist for attenuating the progression of murine systemic lupus erythematosus

Author:
Zhu, Jintao,   et al.   ; Xu, Nan; Li, Jun; Gao, Yujie; Zhou, Nuoya; Ma, Qiuying; Wu, Min; Zhang, Yamin; Sun, Xiaoyan; Xie, Jun; Shen, Guanxin; Yang, Ming; Tu, Qiming; Xu, Xiaowei; Tao, Juan;     Show all 15 Authors
Source:
Biomaterials 2019 v.197 pp. 380-392
ISSN:
0142-9612
Subject:
agonists; animal tissues; apoptosis; autoantibodies; drug carriers; gold; image analysis; inflammation; kidneys; liver; lupus erythematosus; macrophages; mice; nanogold; nanoparticles; pathogenesis; phosphatidylserines; receptors
Abstract:
... Systemic lupus erythematosus (SLE) constitutes an autoimmune disease characterized by the breakdown of tolerance to self-antigens, sustained production of pathogenic autoantibodies, and damage to multiple organs and tissues. Nanoparticle (NP)-based therapeutics have demonstrated efficacy in attenuating the progression of SLE. However, investigations of nano-drugs that address the crucial initiatin ...
DOI:
10.1016/j.biomaterials.2019.01.034

6. Shape-Anisotropic Diblock Copolymer Particles with Varied Internal Structures

Author:
Zhu, Jintao,   et al.   ; Ren, Min; Geng, Zhen; Wang, Ke; Yang, Yi; Tan, Zhengping; Xu, Jiangping; Zhang, Lianbin; Zhang, Lixiong;     Show all 9 Authors
Source:
Langmuir 2019 v.35 no.9 pp. 3461-3469
ISSN:
1520-5827
Subject:
anisotropy; composite polymers; droplets; emulsions; hydrogen bonding; light microscopy; liquids; molecular weight; thermodynamics
Abstract:
... Anisotropic polymer particles have promising applications in various fields, whereas their preparation usually suffers from tedious procedures. Here, we introduce a facile strategy to fabricate novel shape-anisotropic particles with varied internal structures via self-assembly of block copolymers (BCPs), with perfluorooctane (PFO) as the liquid template in emulsion droplets. By increasing the volu ...
DOI:
10.1021/acs.langmuir.8b04147

7. Liquid Crystalline Nanocolloids for the Storage of Electro-Optic Responsive Images

Author:
Zhu, Jintao,   et al.   ; Peng, Haiyan; Yu, Lei; Chen, Guannan; Xue, Zhigang; Liao, Yonggui; Xie, Xiaolin; Smalyukh, Ivan I.; Wei, Yen;     Show all 9 Authors
Source:
ACS applied materials & interfaces 2019 v.11 no.8 pp. 8612-8624
ISSN:
1944-8252
Subject:
colloids; color; composite materials; functional properties; ligands; light scattering; liquid crystals; nanoparticles; separation
Abstract:
... Liquid crystalline nanocolloids (LCNCs), which are nanostructured composites comprising nanoparticles (NPs) and a liquid crystal (LC) host, have attracted a great deal of attention because of their promising new fundamental physical behaviors and functional properties. Yet, it still remains a big challenge to pattern LCNCs into mesoscale-ordered structures due to the limited NP loading in the LC h ...
DOI:
10.1021/acsami.8b22636

8. Synergistic chemo-photodynamic therapy mediated by light-activated ROS-degradable nanocarriers

Author:
Zhu, Jintao,   et al.   ; Chen, Yu; Gao, Yujie; Li, Yuce; Wang, Ke;     Show all 5 Authors
Source:
Journal of materials chemistry B 2019 v.7 no.3 pp. 460-468
ISSN:
2050-7518
Subject:
chemistry; chlorins; cytotoxicity; dextran; doxorubicin; emulsifying; encapsulation; irradiation; nanocarriers; nanoparticles; neoplasm cells; neoplasms; photochemotherapy; photosensitizing agents; polymers
Abstract:
... The combination of chemotherapy and photodynamic therapy (PDT) using polymeric nanocarriers is effective for improving therapeutic efficiency against cancer. Yet, in most reported cases, due to the lack of synergistic mechanisms, chemotherapy and PDT work independently rather than synergistically—the functions of chemotherapeutic drugs and photosensitizers in nanocarriers are independent when they ...
DOI:
10.1039/c8tb03030h

9. Cell-Penetrating Peptides Transport Noncovalently Linked Thermally Activated Delayed Fluorescence Nanoparticles for Time-Resolved Luminescence Imaging

Author:
Zhu, Jintao,   et al.   ; Zhu, Zece; Tian, Di; Gao, Pengli; Wang, Ke; Li, Yuce; Shu, Xuewen; Zhao, Qiang;     Show all 8 Authors
Source:
Journal of the American Chemical Society 2018 v.140 no.50 pp. 17484-17491
ISSN:
1520-5126
Subject:
aqueous solutions; cell membranes; cytotoxicity; fluorescence; fluorescent dyes; hydrophobicity; image analysis; nanoparticles; peptides; permeability
Abstract:
... Luminescent probes and nanoparticles (NPs) with long excited state lifetimes are essential for time-resolved biological imaging. Generally, cell membranes are physiological barriers that could prevent the uptake of many unnatural compounds. It is still a big challenge to prepare biocompatible imaging agents with high cytomembrane permeability, especially for nonmetallic NPs with long-lived lumines ...
DOI:
10.1021/jacs.8b08438

10. Kinetically Controlled Self-Assembly of Block Copolymers into Segmented Wormlike Micelles in Microfluidic Chips

Author:
Zhu, Jintao,   et al.   ; Tan, Zhengping; Lan, Wei; Liu, Qianqian; Wang, Ke; Hussain, Mubashir; Ren, Min; Geng, Zhen; Zhang, Lianbin; Luo, Xiaobing; Zhang, Lixiong;     Show all 11 Authors
Source:
Langmuir 2018 v.35 no.1 pp. 141-149
ISSN:
1520-5827
Subject:
colloids; composite polymers; electron microscopy; micelles; mixing; nanocapsules; pyridines; thermodynamics
Abstract:
... Kinetically controlled self-assembly of block copolymers (BCPs) in solution is an efficient route to fabricate complex hierarchical colloids which are of great importance for nanoencapsulation, microreactors, and biomimics. Herein, segmented wormlike micelles (SWMs) with controllable size are generated by the self-assembly of polystyrene-block-poly(4-vinyl pyridine) in microfluidic channel. Differ ...
DOI:
10.1021/acs.langmuir.8b03028

11. Regulating Block Copolymer Assembly Structures in Emulsion Droplets through Metal Ion Coordination

Author:
Zhu, Jintao,   et al.   ; Wu, Yuqing; Tan, Haiying; Yang, Yi; Li, Yuce; Xu, Jiangping; Zhang, Lixiong;     Show all 7 Authors
Source:
Langmuir 2018 v.34 no.38 pp. 11495-11502
ISSN:
1520-5827
Subject:
composite polymers; droplets; emulsions; evaporation; hydrolysis; iron; lead; metal ions; micelles; pH; protonation; pyridines
Abstract:
... In this report, we demonstrate the metal ion coordination-induced morphological transition of block copolymer assemblies under three-dimensional (3D) confinement. Polystyrene-block-poly(4-vinyl pyridine) (PS-b-P4VP) aggregates with various morphologies can be obtained by emulsion-solvent evaporation in the presence of metal ions (e.g., Pb(II) or Fe(III) ions) in the aqueous phase. Due to the coord ...
DOI:
10.1021/acs.langmuir.8b02135

12. An AIE-based metallo-supramolecular assembly enabling an indicator displacement assay inside living cells

Author:
Zhu, Jintao,   et al.   ; Tian, Di; Li, Fan; Zhu, Zece; Zhang, Lianbin;     Show all 5 Authors
Source:
Chemical communications 2018 v.54 no.64 pp. 8921-8924
ISSN:
1364-548X
Subject:
chemical reactions; coordination compounds; pyrocatechol; zinc
Abstract:
... We report a novel metallo-supramolecular assembly (Z/E-TPE2CyZn-PV), which consists of a tetraphenylethene (TPE)-based dinuclear Zn²⁺–cyclen complex and pyrocatechol violet (PV). The assembly is developed for indicator-displacement assays (IDAs) inside living cells. ...
DOI:
10.1039/c8cc03274b

13. Gel Phase Membrane Retards Amyloid β-Peptide (1–42) Fibrillation by Restricting Slaved Diffusion of Peptides on Lipid Bilayers

Author:
Zhu, Jintao,   et al.   ; Yang, Mengting; Wang, Kang; Lin, Jiake; Wang, Liqun; Wei, Feng; Zheng, Wanquan; Shen, Lei;     Show all 8 Authors
Source:
Langmuir 2018 v.34 no.28 pp. 8408-8414
ISSN:
1520-5827
Subject:
Alzheimer disease; amyloid beta-peptides; brain; fluorescence microscopy; gels; humans; lipid bilayers; lipids; liquids; neurotoxicity; pathogenesis; plasma membrane; spectroscopy
Abstract:
... Plasma membranes in the human brain can interact with amyloid β-peptide (1–42; Aβ₄₂) and induce Aβ₄₂ fibrillation, which is considered to be a crucial process underlying the neurotoxicity of Aβ₄₂ and the pathogenesis of Alzheimer’s disease (AD). However, the mechanism of membrane-mediated Aβ₄₂ fibrillation at the molecular level remains elusive. Here we study the role of adsorbed Aβ₄₂ peptides on ...
DOI:
10.1021/acs.langmuir.8b01315

14. Responsive Photonic Hydrogel-Based Colorimetric Sensors for Detection of Aldehydes in Aqueous Solution

Author:
Zhu, Jintao,   et al.   ; Jia, Xiaolu; Zhang, Tian; Wang, Jianying; Wang, Ke; Tan, Haiying; Hu, Yuandu; Zhang, Lianbin;     Show all 8 Authors
Source:
Langmuir 2018 v.34 no.13 pp. 3987-3992
ISSN:
1520-5827
Subject:
aqueous solutions; chemical reactions; color; colorimetry; formaldehyde; hydrogels; iron oxides; nanoparticles; photons; polyacrylamide
Abstract:
... In this work, we present a fast and efficient strategy for the preparation of responsive photonic hydrogels for aldehyde sensing by combining the self-assembly of monodisperse carbon-encapsulated Fe₃O₄ nanoparticles (NPs) and in situ photopolymerization of polyacrylamide (PAM) hydrogels. The responsive photonic hydrogels exhibit structural color variation after being treated with formaldehyde aque ...
DOI:
10.1021/acs.langmuir.8b00186

15. Au Nanocage-Strengthened Dissolving Microneedles for Chemo-Photothermal Combined Therapy of Superficial Skin Tumors

Author:
Zhu, Jintao,   et al.   ; Dong, Liyun; Li, Yuce; Li, Zhao; Xu, Nan; Liu, Pei; Du, Hongyao; Zhang, Yamin; Huang, Yuqiong; Zhu, Jinjin; Ren, Guichao; Xie, Jun; Wang, Ke; Zhou, Yajie; Shen, Chen; Tao, Juan;     Show all 16 Authors
Source:
ACS applied materials & interfaces 2018 v.10 no.11 pp. 9247-9256
ISSN:
1944-8252
Subject:
adverse effects; antineoplastic activity; doxorubicin; drug therapy; gold; hyaluronic acid; irradiation; mice; nanogold; skin neoplasms; strength (mechanics); surgery; topical therapy
Abstract:
... For superficial skin tumors (SST) with high incidence, surgery and systemic therapy are relatively invasive and possible to cause severe side effect, respectively. Yet, topical therapy is confronted with the limited transdermal capacity because of the stratum corneum barrier layer of skin. Therefore, it is crucial to develop a highly effective and minimally invasive alternative transdermal approac ...
DOI:
10.1021/acsami.7b18293

16. Photothermal Effect-Triggered Drug Release from Hydrogen Bonding-Enhanced Polymeric Micelles

Author:
Zhu, Jintao,   et al.   ; Li, Yuce; Ding, Jianxun; Tian, Huayu; Chen, Xuesi;     Show all 5 Authors
Source:
Biomacromolecules 2018 v.19 no.6 pp. 1950-1958
ISSN:
1526-4602
Subject:
antineoplastic activity; chemical structure; composite polymers; doxorubicin; hydrogen; hydrogen bonding; hydrophobicity; irradiation; lysine; micelles; polyethylene glycol; therapeutics; thiourea; urea; urethane
Abstract:
... Incorporation of noncovalent interactions into hydrophobic cores of polymeric micelles provides the micelles with enhanced physical stability and drug loading efficiency, however, it also creates obstacles for drug release due to the strong interactions between carriers and drugs. Herein, a series of amphiphilic block copolymers based on poly(ethylene glycol)-b-poly(l-lysine) (mPEG-b-PLL) with sim ...
DOI:
10.1021/acs.biomac.7b01702

17. Facile Strategy to Generate Aligned Polymer Nanofibers: Effects on Cell Adhesion

Author:
Zhu, Jintao,   et al.   ; Wang, Kui; Liu, Liping; Xie, Jun; Shen, Lei; Tao, Juan;     Show all 6 Authors
Source:
ACS applied materials & interfaces 2018 v.10 no.2 pp. 1566-1574
ISSN:
1944-8252
Subject:
adhesion; cell adhesion; electric power; fibroblasts; glass; melanoma; mice; molecular weight; nanofibers; polymers
Abstract:
... Structure of polymer fiber membranes plays a vital role in controlling cell responses as applied to immobilize targets for specific cell interactions. Electrospinning is a simple and powerful method to prepare polymer fiber membranes with scales from nano- to micrometers. In this report, a facile yet versatile strategy has been developed for fabricating polymer nanofiber membranes with well-aligne ...
DOI:
10.1021/acsami.7b16057

18. Liposomes-coated gold nanocages with antigens and adjuvants targeted delivery to dendritic cells for enhancing antitumor immune response

Author:
Zhu, Jintao,   et al.   ; Liang, Ruijing; Xie, Jun; Li, Jun; Wang, Ke; Liu, Liping; Gao, Yujie; Hussain, Mubashir; Shen, Guanxin; Tao, Juan;     Show all 10 Authors
Source:
Biomaterials 2017 v.149 pp. 41-50
ISSN:
0142-9612
Subject:
antibodies; cytotoxic T-lymphocytes; dendritic cells; engineering; fluorescence; gold; image analysis; immune response; immunotherapy; liposomes (artificial); lungs; lymph nodes; melanoma-specific antigens; metastasis; models; nanogold; neoplasms; vaccine adjuvants
Abstract:
... For nanovaccine-based cancer immunotherapy, dendritic cells (DCs) are one of the most powerful antigen presenting cells (APCs) that initiate and promote the maturation of antigen-specific cytotoxic T lymphocytes (e.g., CD8+ T cells) to induce the local and systemic antitumor immunity and further suppress the tumor metastasis and produce long-term protection against tumor. Thus, the activation and ...
DOI:
10.1016/j.biomaterials.2017.09.029

19. Emulsion Solvent Evaporation-Induced Self-Assembly of Block Copolymers Containing pH-Sensitive Block

Author:
Zhu, Jintao,   et al.   ; Wu, Yuqing; Wang, Ke; Tan, Haiying; Xu, Jiangping;     Show all 5 Authors
Source:
Langmuir 2017 v.33 no.38 pp. 9889-9896
ISSN:
1520-5827
Subject:
composite polymers; droplets; emulsions; evaporation; hydrophilicity; micelles; microparticles; mixing; molecular weight; oils; pH; solvents; temperature
Abstract:
... A simple yet efficient method is developed to manipulate the self-assembly of pH-sensitive block copolymers (BCPs) confined in emulsion droplets. Addition of acid induces significant variation in morphological transition (e.g., structure and surface composition changes) of the polystyrene-block-poly(4-vinylpyridine) (PS-b-P4VP) assemblies, due to the hydrophobic–hydrophilic transition of the pH-se ...
DOI:
10.1021/acs.langmuir.7b02330

20. Dacarbazine-Loaded Hollow Mesoporous Silica Nanoparticles Grafted with Folic Acid for Enhancing Antimetastatic Melanoma Response

Author:
Zhu, Jintao,   et al.   ; Liu, Qianqian; Xu, Nan; Liu, Liping; Li, Jun; Zhang, Yamin; Shen, Chen; Shezad, Khurram; Zhang, Lianbin; Tao, Juan;     Show all 10 Authors
Source:
ACS Applied Materials & Interfaces 2017 v.9 no.26 pp. 21673-21687
ISSN:
1944-8252
Subject:
cytotoxicity; drug therapy; drugs; encapsulation; folic acid; macrophages; melanoma; metastasis; nanocarriers; nanomedicine; nanoparticles; photosensitivity; porous media; silica; solubility
Abstract:
... Dacarbazine (DTIC) is one of the most important chemotherapeutic agents for the treatment of melanoma; however, its poor solubility, photosensitivity, instability, and serious toxicity to normal cells limit its clinical applications. In this article, we present a rationally designed nanocarrier based on hollow mesoporous silica nanoparticles (HMSNs) for the encapsulation and targeted release of DT ...
DOI:
10.1021/acsami.7b05278