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61. Biological Applications and Toxicity Minimization of Semiconductor Quantum Dots

Author:
Filali, Samira; Pirot, Fabrice; Miossec, Pierre
Source:
Trends in biotechnology 2020 v.38 no.2 pp. 163-177
ISSN:
0167-7799
Subject:
toxicity,   etc   ; human health; image analysis; laboratory techniques; quantum dots; therapeutics;     Show all 6 Subjects
Abstract:
... The extraordinary potential of semiconductor quantum dots (QDs) has resulted in their widespread application in various fields, from engineering technology and the development of laboratory techniques to biomedical imaging and therapeutic strategies. However, the toxicity of QDs remains a concern and has limited their applications in human health. Better understanding of the behavior of QDs as it ...
DOI:
10.1016/j.tibtech.2019.07.013

62. Distribution of quetiapine and metabolites in biological fluids and tissues

Author:
Vignali, Claudia; Freni, Francesca; Magnani, Camilla; Moretti, Matteo; Siodambro, Chiara; Groppi, Angelo; Osculati, Antonio Marco Maria; Morini, Luca
Source:
Forensic science international 2020 v.307 pp. 110108
ISSN:
0379-0738
Subject:
toxicity,   etc   ; antipsychotics; blood; death; metabolites; poisoning; quantitative analysis; tissues;     Show all 8 Subjects
Abstract:
... Quetiapine is an atypical antipsychotic drug, frequently found in post-mortem samples. The quantitative determination of active metabolites may help in the interpretation of the potential toxic effects of the parent drug and its role in death. A fully validated LC–MS/MS method was developed for the identification and quantification of quetiapine and two main metabolites (N-desalkylquetiapine and 7 ...
DOI:
10.1016/j.forsciint.2019.110108

63. Factor diagnosis and future governance of dangerous goods accidents in China’s ports

Author:
Chen, Jihong; Zheng, Huiying; Wei, Ling; Wan, Zheng; Ren, Ruisi; Li, Jie; Li, Haoqiang; Bian, Wentao; Gao, Manjia; Bai, Yun
Source:
Environmental pollution 2020 v.257 pp. 113582
ISSN:
0269-7491
Subject:
toxicity,   etc   ; accidents; case studies; equipment; financial economics; governance; models; China;     Show all 8 Subjects
Abstract:
... Dangerous goods are particularly hazardous, as they can be flammable, explosive, and toxic. These characteristics make them vulnerable to accidents, and such mishaps during port operations can lead to massive economic losses and even deaths. It is, therefore, necessary and important to analyze and study the dangerous goods accidents at ports, so as to identify major factors and prevent them. Forma ...
DOI:
10.1016/j.envpol.2019.113582

64. In silico MS/MS spectra for identifying unknowns: a critical examination using CFM-ID algorithms and ENTACT mixture samples

Author:
Chao, Alex; Al-Ghoul, Hussein; McEachran, Andrew D.; Balabin, Ilya; Transue, Tom; Cathey, Tommy; Grossman, Jarod N.; Singh, Randolph R.; Ulrich, Elin M.; Williams, Antony J.; Sobus, Jon R.
Source:
Analytical and bioanalytical chemistry 2020 v.412 no.6 pp. 1303-1315
ISSN:
1618-2642
Subject:
toxicity,   etc   ; algorithms; databases; tandem mass spectrometry; toxic substances;     Show all 5 Subjects
Abstract:
... High-resolution mass spectrometry (HRMS) enables rapid chemical annotation via accurate mass measurements and matching of experimentally derived spectra with reference spectra. Reference libraries are generated from chemical standards and are therefore limited in size relative to known chemical space. To address this limitation, in silico spectra (i.e., MS/MS or MS2 spectra), predicted via Competi ...
DOI:
10.1007/s00216-019-02351-7
PubMed:
31965249
PubMed Central:
PMC7021669

65. Lead Impact on the Earthworm Eisenia fetida and Earthworm Recovery after Exposure

Author:
Žaltauskaitė, Jūratė; Kniuipytė, Inesa; Kugelytė, Rūta
Source:
Water, air, and soil pollution 2020 v.231 no.2 pp. 49
ISSN:
0049-6979
Subject:
toxicity,   etc   ; Eisenia fetida; adults; earthworms; lead; lipid peroxidation; malondialdehyde; soil;     Show all 8 Subjects
Abstract:
... This study investigates the effects of lead (Pb) on earthworm Eisenia fetida and its potential to recover from Pb exposure. Adult earthworms E. fetida were exposed for 4 weeks to lead (40–2500 mg Pb kg⁻¹) in soil, and after the period of exposure, earthworms were transferred to clean unpolluted soil for 4 weeks to recover. Pb had no effect on the earthworm’s survival but inhibited earthworm growth ...
DOI:
10.1007/s11270-020-4428-y

66. Structural insights into the interaction of botulinum neurotoxin a with its neuronal receptor SV2C

Author:
Li, Xiaodan; Brunner, Cyrill; Wu, Yufan; Leka, Oneda; Schneider, Gisbert; Kammerer, Richard A.
Source:
Toxicon 2020 v.175 pp. 36-43
ISSN:
0041-0101
Subject:
toxicity,   etc   ; botulinum toxin; crystal structure; glycoproteins; neurons; synaptic vesicles;     Show all 6 Subjects
Abstract:
... A dual-receptor interaction with a polysialoganglioside and synaptic vesicle glycoprotein 2 (SV2) is required for botulinum neurotoxin A (BoNT) toxicity. Here, we review what is currently known about the BoNT/A-SV2 interaction based on structural studies. Currently, five crystal structures of the receptor–binding domain (Hc) of BoNT subtypes A1 and A2 complexed to the large luminal domain (LD4) of ...
DOI:
10.1016/j.toxicon.2019.11.010

67. Copper-catalyzed fragmentation-rearrangement sequence of cycloketoxime esters

Author:
Wu, Yixiao; Zhao, Binlin; Shi, Zhuangzhi; Yuan, Yu
Source:
Tetrahedron 2020 v.76 no.5 pp. 130873
ISSN:
0040-4020
Subject:
toxicity,   etc   ; catalytic activity; chemical reactions; esters; moieties; nitriles; tetrabutylammonium compounds;     Show all 7 Subjects
Abstract:
... Copper-catalyzed fragmentation-rearrangement sequence of cycloketoxime esters is reported. This strategy provides direct access to diverse ring-opening acyloxylation nitriles avoiding the use of toxic cyanic reagents with good atom economy and well functional group tolerance. Experimental exploration showed that tetrabutylammonium bromide (TBAB) played an irreplaceable role in this transformation. ...
DOI:
10.1016/j.tet.2019.130873

68. Cysteine Toxicity Drives Age-Related Mitochondrial Decline by Altering Iron Homeostasis

Author:
Hughes, Casey E.; Coody, Troy K.; Jeong, Mi-Young; Berg, Jordan A.; Winge, Dennis R.; Hughes, Adam L.
Source:
Cell 2020 v.180 no.2 pp. 296-310.e18
ISSN:
0092-8674
Subject:
toxicity,   etc   ; cysteine; homeostasis; iron; lysosomes; mitochondria; vacuoles; yeasts;     Show all 8 Subjects
Abstract:
... Mitochondria and lysosomes are functionally linked, and their interdependent decline is a hallmark of aging and disease. Despite the long-standing connection between these organelles, the function(s) of lysosomes required to sustain mitochondrial health remains unclear. Here, working in yeast, we show that the lysosome-like vacuole maintains mitochondrial respiration by spatially compartmentalizin ...
DOI:
10.1016/j.cell.2019.12.035
PubMed:
31978346
PubMed Central:
PMC7164368

69. Recent topics on reusable immobilized iron nanoparticle pre-catalysts

Author:
Yamada, Makito; Arisawa, Mitsuhiro
Source:
Tetrahedron letters 2020 v.61 no.4 pp. 151422
ISSN:
0040-4039
Subject:
toxicity,   etc   ; catalysts; chemical reactions; chemical structure; iron; nanoparticles; organic compounds;     Show all 7 Subjects
Abstract:
... Transition metals have been used as catalysts for various reactions and thoroughly developed. Among these metals, the noble metals have been the ones mainly used as catalysts. However, they are expensive due to the small quantities of these materials on earth. Therefore, the development of catalysts using a earth-abundant metals is sought as a replacement for noble metal catalysts. Among the abund ...
DOI:
10.1016/j.tetlet.2019.151422

70. Biomimetic cell-derived nanocarriers for modulating immune responses

Author:
Qin, Ming; Du, Guangsheng; Sun, Xun
Source:
Biomaterials science 2020 v.8 no.2 pp. 530-543
ISSN:
2047-4849
Subject:
toxicity,   etc   ; biocompatibility; biomimetics; cell membranes; coatings; immune response; immunotherapy; nanocarriers;     Show all 8 Subjects
Abstract:
... Immunotherapy has become an increasingly important area in the medical field at present. As it is often difficult for synthetic carriers to overcome regulatory hurdles for clinical translation, bionic cell-derived carriers are attracting considerable interest due to their better biocompatibility and lower toxicity. Moreover, biomimetic cell-derived nanocarriers may achieve different specific biolo ...
DOI:
10.1039/c9bm01444f

71. Highly efficient anaerobic co-degradation of complex persistent polycyclic aromatic hydrocarbons by a bioelectrochemical system

Author:
Zhou, Yukang; Zou, Qingping; Fan, Mengjie; Xu, Yuan; Chen, Yingwen
Source:
Journal of hazardous materials 2020 v.381 pp. 120945
ISSN:
0304-3894
Subject:
toxicity,   etc   ; anodes; biodegradation; bioelectrochemistry; ecosystems; metabolism; microbial communities; phenanthrenes;     Show all 8 Subjects
Abstract:
... Polycyclic aromatic hydrocarbons (PAHs) that undergo long-distance migration and have strong biological toxicity are a great threat to the health of ecosystems. In this study, the biodegradation characteristics and combined effects of mixed PAHs in bioelectrochemical systems (BESs) were studied. The results showed that, compared with a mono-carbon source, low-molecular-weight PAHs (LMW PAHs)-napht ...
DOI:
10.1016/j.jhazmat.2019.120945

72. The Importance of Derivatizing Reagent in Chromatography Applications for Biogenic Amine Detection in Food and Beverages

Author:
Munir, Muhammad Abdurrahman; Badri, Khairiahi Haji
Source:
Journal of Analytical Methods in Chemistry (Online) 2020 v.2020
ISSN:
2090-8873
Subject:
toxicity,   etc   ; beverages; derivatization; gas chromatography; histamine; humans; liquid chromatography;     Show all 7 Subjects
Abstract:
... Biogenic amines (BA) are chemical compounds formed in foods that contain protein, allowing the foods to undergo a bacterial degradation process. Biogenic amines are labeled as toxic food because its consumption exceeding the FDA regulation (50 mg/kg) can be harmful to humans. Some countries also have regulations that prohibit the consumption of biogenic amines in high concentrations, especially hi ...
DOI:
10.1155/2020/5814389
PubMed:
32377440
PubMed Central:
PMC7199571

73. Biocatalytic production of 2,5-furandicarboxylic acid: recent advances and future perspectives

Author:
Yuan, Haibo; Liu, Hongling; Du, Jieke; Liu, Kaiquan; Wang, Tengfei; Liu, Long
Source:
Applied microbiology and biotechnology 2020 v.104 no.2 pp. 527-543
ISSN:
0175-7598
Subject:
toxicity,   etc   ; biocatalysis; biodegradation; dicarboxylic acids; electrochemistry; hydroxymethylfurfural; photocatalysis; polymers;     Show all 8 Subjects
Abstract:
... 2,5-Furandicarboxylic acid (FDCA) is attracting increasing attention because of its potential applications as a sustainable substitute to petroleum-derived terephthalic acid for the production of bio-based polymers, such as poly(ethylene 2,5-furandicarboxylate) (PEF). Many catalytic methods have been developed for the synthesis of FDCA, including chemocatalysis, biocatalysis, photocatalysis, and e ...
DOI:
10.1007/s00253-019-10272-9

74. Global harmonization of vaccine testing requirements: Making elimination of the ATT and TABST a concrete global achievement

Author:
Viviani, Laura; Halder, Marlies; Gruber, Marion; Bruckner, Lukas; Cussler, Klaus; Sanyal, Gautam; Srinivas, Geetha; Goel, Sunil; Kaashoek, Marianne; Litthauer, Derek; Lopes da Silva, Arthur Leonardo; Sakanyan, Elena; Aprea, Patricia; Jin, Hongtao; Vandeputte, Joris; Seidle, Troy; Yakunin, Dimitriy
Source:
Biologicals 2020 v.63 pp. 101-105
ISSN:
1045-1056
Subject:
toxicity testing,   etc   ; experts; humans; laboratory animals; vaccine development; vaccines; China;     Show all 7 Subjects
Abstract:
... This one-day symposium organized by Humane Society International (HSI) brought together 18 international experts from Argentina, Brazil, China, Europe, India, Russia, South Africa and the United States to discuss the elimination of the abnormal toxicity test (ATT) from the testing requirements for human vaccines as well as the target animal batch safety test (TABST) and the laboratory animal batch ...
DOI:
10.1016/j.biologicals.2019.10.007

75. Transfer of elements released by aluminum galvanic anodes in a marine sedimentary compartment after long-term monitoring in harbor and laboratory environments

Author:
Caplat, C.; Basuyaux, O.; Pineau, S.; Deborde, J.; Grolleau, A.M.; Leglatin, S.; Mahaut, M.L.
Source:
Chemosphere 2020 v.239 pp. 124720
ISSN:
0045-6535
Subject:
toxicity,   etc   ; agitation; aluminum; anodes; aquatic organisms; monitoring; sediments; zinc; France;     Show all 9 Subjects
Abstract:
... Cathodic protection by galvanic anodes (GACP) is often used to protect immerged metallic structures in harbor environments, especially GACP employing aluminum-based anodes. To follow a previous study that was performed in a laboratory on Al-anode, two monitoring periods were performed in parallel, one in an in situ environment (in the Port of Calais) for 42 months and the other in a laboratory for ...
DOI:
10.1016/j.chemosphere.2019.124720

76. Transformation and toxicity of environmental contaminants as influenced by Fe containing clay minerals: a review

Author:
Wang, Yi; Jin, Xin; Peng, Anping; Gu, Cheng
Source:
Bulletin of environmental contamination and toxicology 2020 v.104 no.1 pp. 8-14
ISSN:
0007-4861
Subject:
toxicity,   etc   ; clay; clay minerals; crystal structure; iron; pollution; sediments; soil;     Show all 8 Subjects
Abstract:
... Clay minerals are ubiquitous in soil and sediments, and play important roles in environmental processes. Virtually all clay minerals contain some Fe, either in the crystal structure or adsorbed at the surface of the clay minerals, which could promote many reactions on the clay minerals. The interaction between Fe containing clay mineral and its surrounding contaminants would greatly affect the tra ...
DOI:
10.1007/s00128-019-02747-2

77. Unexpected identification and characterization of a cathinone precursor in the new psychoactive substance market: 3′,4′-methylenedioxy-2,2-dibromobutyrophenone

Author:
Armenta, Sergio; Gil, Cristina; Ventura, Mireia; Esteve-Turrillas, Francesc A.
Source:
Forensic science international 2020 v.306 pp. 110043
ISSN:
0379-0738
Subject:
toxicity,   etc   ; Internet; ketamine; markets; nuclear magnetic resonance spectroscopy; psychotropic agents;     Show all 6 Subjects
Abstract:
... 3′,4′-methylenedioxy-2,2-dibromobutyrophenone has been identified and fully characterized in a sample obtained from an anonymous consumer acquired as ketamine through the Internet market. The substance has been deeply characterized by using standard and high performance analytical techniques such as: attenuated total reflectance-infrared spectroscopy, gas chromatography–mass spectrometry, high-res ...
DOI:
10.1016/j.forsciint.2019.110043

78. Removal and biomineralization of Pb2+ in water by fungus Phanerochaete chrysoporium

Author:
Zhao, Wei-Wei; Zhu, Gangqiang; Daugulis, Andrew J.; Chen, Qi; Ma, Hong-Yan; Zheng, Peng; Liang, Jian; Ma, Xiao-kui
Source:
Journal of cleaner production 2020 v.260 pp. 120980
ISSN:
0959-6526
Subject:
toxicity; toxicity testing,   etc   ; Phanerochaete; biomineralization; enzyme activity; fungi; hyphae; lead; lead nitrate; mycelium; organic phosphorus; pH; phosphates; water pollution;     Show all 14 Subjects
Abstract:
... The removal and biomineralization of Pb²⁺ (200 mg/L) in water were investigated utilizing mature mycelia of Phanerochaete chrysoporium. Mycelial dosage, initial Pb²⁺ concentration, solution pH and treatment time all were shown to have an influence on Pb²⁺ removal. Granular, lead-containing precipitation was formed on the fungal hyphae upon exposure to lead nitrate, which was confirmed from scannin ...
DOI:
10.1016/j.jclepro.2020.120980

79. The fate and toxicity of Pb-based perovskite nanoparticles on soil bacterial community: Impacts of pH, humic acid, and divalent cations

Author:
Zhai, Yujia; Wang, Zhuang; Wang, Guiyin; Peijnenburg, Willie J.G.M.; Vijver, Martina G.
Source:
Chemosphere 2020 v.249 pp. 126564
ISSN:
0045-6535
Subject:
toxicity; toxicity testing,   etc   ; bacterial communities; cations; environmental factors; humic acids; nanoparticles; pH; recycling; soil bacteria; solar cells; wastes;     Show all 12 Subjects
Abstract:
... Pb-based perovskite nanoparticles (PbPNPs) are amongst others used within highly efficient solar cells. PbPNPs can be released into the environment during their production, recycling or waste processing. In this study we investigated the fate and toxicity of PbPNPs on soil bacterial community under simulated natural environmental conditions across a range of pH, humic acid, and divalent cation con ...
DOI:
10.1016/j.chemosphere.2020.126564

80. Comparing passive dosing and solvent spiking methods to determine the acute toxic effect of pentachlorophenol on Daphnia magna

Author:
Kwon, Hyun-ah; Jeong, Yoonah; Jeon, Hyun Pyo; Kim, Sanghun
Source:
Ecotoxicology 2020 v.29 no.3 pp. 286-294
ISSN:
0963-9292
Subject:
acute toxicity; toxicity testing,   etc   ; Daphnia magna; hydrophobicity; median effective concentration; methanol; pentachlorophenol; pollutants; risk assessment; silicone; solvents; sorption; volatilization;     Show all 13 Subjects
Abstract:
... Pentachlorophenol (PCP) is a widespread and persistent hydrophobic organic pollutant in the environment despite its restricted public use. Risk assessment of such hydrophobic organic compounds (HOCs) is challenging because sorption and volatilization issues during toxicity test often lead to inconsistent exposure concentration. Considering the hydrophobicity of the PCP, in this study, a passive do ...
DOI:
10.1007/s10646-020-02172-w