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1. Mesenchymal stem cells in combination with low-dose rapamycin significantly prolong islet allograft survival through induction of regulatory T cells

Author:
Xu, Danmei,   et al.   ; Duan, Wu; Yu, Xuefeng; Ma, Dongxia; Yang, Bo; Li, Yi; Huang, Li; Liu, Li; Chen, Gang; Ding, Yunchuan;     Show all 10 Authors
Source:
Biochemical and biophysical research communications 2018 v.506 no.3 pp. 619-625
ISSN:
0006-291X
Subject:
T-lymphocytes; allografting; animal models; antigens; islets of Langerhans; lymph nodes; mesenchymal stromal cells; mice; protective effect; rapamycin
Abstract:
... We previously demonstrated the protective effect of MSCs in an adaptive transfer mouse model. However, their therapeutic potential in an allogeneic immunocompetent setting mimicking clinical context of islet transplantation remained unknown. The aim of this study was to determine whether MSCs therapy, either by itself, or combined with Rapamycin could benefit the allograft survival of fully MHC-mi ...
DOI:
10.1016/j.bbrc.2018.10.070