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1. A simple HPLC method for plasma level monitoring of mitotane and its two main metabolites in adrenocortical cancer patients

Author:
Sakoff, Jennette A.,   et al.   ; Garg, Madhu B.; Ackland, Stephen P.;     Show all 3 Authors
Source:
Journal of chromatography 2011 v.879 no.23 pp. 2201-2205
ISSN:
1570-0232
Subject:
DDD (pesticide); DDE (pesticide); acetic acid; carcinoma; ethane; ethanol; ethylene; high performance liquid chromatography; metabolites; metastasis; mitotane; monitoring; patients; pharmacokinetics; therapeutics
Abstract:
... Mitotane (o,p′-DDD or (1,1-dichloro-2-[o-chlorophenyl]-2-[p-chlorophenyl]ethane, DDD) is the drug of choice for non-resectable and metastatic adrenocortical carcinomas (ACC). Measurement of mitotane and metabolites, o,p′-DDE (1,1-dichloro-2-[p-chlorophenyl]-2-[o-chlorophenyl]ethene, DDE) and o,p′-DDA (1,1-[o,p′-dichlorodiphenyl] acetic acid, DDA) provides a better understanding of mitotane pharmac ...
DOI:
10.1016/j.jchromb.2011.06.001

2. Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition

Author:
Sakoff, Jennette,   et al.   ; von Kleist, Lisa; Stahlschmidt, Wiebke; Bulut, Haydar; Gromova, Kira; Puchkov, Dmytro; Robertson, Mark J.; MacGregor, Kylie A.; Tomilin, Nikolay; Pechstein, Arndt; Chau, Ngoc; Chircop, Megan; von Kries, Jens Peter; Saenger, Wolfram; Kräusslich, Hans-Georg; Shupliakov, Oleg; Robinson, Phillip J.; McCluskey, Adam; Haucke, Volker;     Show all 19 Authors
Source:
Cell 2011 v.146 no.3 pp. 471-484
ISSN:
0092-8674
Subject:
Human immunodeficiency virus; X-ray diffraction; clathrin; dissociation; dynamins; endocytosis; growth factors; pathogens; receptors; synaptic transmission; synaptic vesicles; viruses
Abstract:
... Clathrin-mediated endocytosis (CME) regulates many cell physiological processes such as the internalization of growth factors and receptors, entry of pathogens, and synaptic transmission. Within the endocytic network, clathrin functions as a central organizing platform for coated pit assembly and dissociation via its terminal domain (TD). We report the design and synthesis of two compounds named p ...
DOI:
10.1016/j.cell.2011.06.025

3. The influence of ionic liquids on the Knoevenagel condensation of 1H-pyrrole-2-carbaldehyde with phenyl acetonitriles – cytotoxic 3-substituted-(1H-pyrrol-2-yl)acrylonitriles

Author:
Sakoff, Jennette A.,   et al.   ; Al Otaibi, Ahmed; Gordon, Christopher P.; Gilbert, Jayne; McCluskey, Adam;     Show all 5 Authors
Source:
RSC advances 2014 v.4 no.38 pp. 19806-19813
ISSN:
2046-2069
Subject:
acetonitrile; ammonium nitrate; breast neoplasms; bromine; catalytic activity; cell growth; condensation reactions; cytotoxicity; human cell lines; ionic liquids; neoplasm cells; piperidines; screening
Abstract:
... The Knoevenagel condensation of a series of substituted phenyl acetonitriles with 1H-pyrrole-2-carbaldehyde was examined in seven 1-butyl-3-methylimidazolium based ionic liquids and three protic ionic liquids. Of these [BMIM][Br] and [BMIM][OH], with catalytic piperidine, proved most efficient affording 3-substituted-(1H-pyrrol-2-yl)acrylonitriles 3–17 in good to excellent yields (98%) whilst util ...
DOI:
10.1039/c3ra47418f

4. Physicochemical, antioxidant and anti-cancer activity of a Eucalyptus robusta (Sm.) leaf aqueous extract

Author:
Sakoff, Jennette A.,   et al.   ; Vuong, Quan V.; Hirun, Sathira; Chuen, Tiffany L.K.; Goldsmith, Chloe D.; Munro, Benjamin; Bowyer, Michael C.; Chalmers, Anita C.; Phillips, Phoebe A.; Scarlett, Christopher J.;     Show all 10 Authors
Source:
Industrial crops and products 2015 v.64 pp. 167-174
ISSN:
0926-6690
Subject:
Eucalyptus robusta; alpha-tocopherol; animal ovaries; antineoplastic activity; antioxidant activity; antioxidants; ascorbic acid; brain; coasts; colon; drug therapy; essential oils; health promotion; leaf extracts; leaves; pancreatic neoplasms; phenolic compounds; spray drying; toxicity; trees; Australia
Abstract:
... Eucalyptus robusta (Sm.) (ER) is a widely distributed tree native to the east coast of Australia, which has also been established in numerous other countries. ER leaves contain high levels of essential oils and are rich in total phenolic compounds (TPC), which have been linked with health benefits; however, there is limited information on the bioactivity of ER leaf extracts. This study aimed to op ...
DOI:
10.1016/j.indcrop.2014.10.061

5. Antioxidant and anti-proliferative properties of Davidson’s plum (Davidsonia pruriens F. Muell) phenolic-enriched extracts as affected by different extraction solvents

Author:
Sakoff, Jennette A.,   et al.   ; Chuen, Tiffany L.K.; Vuong, Quan V.; Hirun, Sathira; Bowyer, Michael C.; Predebon, Melanie J.; Goldsmith, Chloe D.; Scarlett, Christopher J.;     Show all 8 Authors
Source:
Journal of herbal medicine 2016 v.6 no.4 pp. 187-192
ISSN:
2210-8041
Subject:
2,2-diphenyl-1-picrylhydrazyl; acetone; anthocyanidins; antioxidant activity; antioxidants; bioactive compounds; brain; breasts; cell lines; colon; ethanol; fruits; functional foods; herbal medicines; industry; lungs; methanol; neoplasm cells; neoplasms; phytopharmaceuticals; plums; proanthocyanidins; solvents; Australia
Abstract:
... The Davidson’s plum (DP; Davidsonia pruriens F. Muell) is a fruit native to Australia that is a rich source of phenolic compounds. This study investigated the effects of various extraction solvents (ethanol, methanol, acetone and water) on total phenolic content (TPC), antioxidant capacity (ABTS, DPPH, CUPRAC, FRAP assays) and anti-proliferative activity (MTT, CCK-8 assays) of DP. Our data reveale ...
DOI:
10.1016/j.hermed.2016.08.005

6. In vitro anticancer properties of selected Eucalyptus species Animal

Author:
Sakoff, Jennette,   et al.   ; Bhuyan, Deep Jyoti; Bond, Danielle R.; Predebon, Melanie; Vuong, Quan V.; Chalmers, Anita C.; van Altena, Ian A.; Bowyer, Michael C.; Scarlett, Christopher J.;     Show all 9 Authors
Source:
In vitro cellular & developmental biology 2017 v.53 no.7 pp. 604-615
ISSN:
1071-2690
Subject:
Eucalyptus microcorys; Eucalyptus robusta; Eucalyptus saligna; antineoplastic activity; apoptosis; caspases; cell growth; cytotoxicity; drug therapy; fruit extracts; growth retardation; in vitro studies; inhibitory concentration 50; leaves; mechanism of action; neoplasm cells; pancreatic neoplasms; phytopharmaceuticals; survival rate
Abstract:
... In spite of the recent advancements in oncology, the overall survival rate for pancreatic cancer has not improved over the last five decades. Eucalypts have been linked with cytotoxic and anticancer properties in various studies; however, there is very little scientific evidence that supports the direct role of eucalypts in the treatment of pancreatic cancer. This study assessed the anticancer pro ...
DOI:
10.1007/s11626-017-0149-y

7. Screening phytochemical content, antioxidant, antimicrobial and cytotoxic activities of Catharanthus roseus (L.) G. Don stem extract and its fractions

Author:
Sakoff, Jennette A.,   et al.   ; Pham, Hong Ngoc Thuy; Vuong, Quan Van; Bowyer, Michael C.; Scarlett, Christopher J.;     Show all 5 Authors
Source:
Biocatalysis and agricultural biotechnology 2018 v.16 pp. 405-411
ISSN:
1878-8181
Subject:
Catharanthus roseus; Escherichia coli; antioxidant activity; antioxidants; apigenin; bioactive compounds; breasts; butanol; cell lines; colon; cytotoxicity; drugs; gallic acid; glioblastoma; high performance liquid chromatography; kaempferol; liquid-liquid extraction; lungs; methanol; neoplasm cells; pancreas; saponins; screening; therapeutics; ultrasonic treatment
Abstract:
... The aims of this study were to screen the phytochemical content, antioxidant, antimicrobial and cytotoxic properties of the extract and its fractions prepared from Catharanthus roseus (L.) G. Don (C. roseus) stem. C. roseus stem was powdered and extracted with methanol using ultrasound-assisted extraction to obtain the crude extract. The crude extract was further fractioned using liquid-liquid ext ...
DOI:
10.1016/j.bcab.2018.09.005

8. In vitro antibacterial and anticancer properties of Helicteres hirsuta Lour. leaf and stem extracts and their fractions

Author:
Sakoff, Jennette A.,   et al.   ; Pham, Hong Ngoc Thuy; Bond, Danielle R.; Vuong, Quan Van; Bowyer, Michael C.; Scarlett, Christopher J.;     Show all 6 Authors
Source:
Molecular biology reports 2018 v.45 no.6 pp. 2125-2133
ISSN:
0301-4851
Subject:
Escherichia coli; Helicteres; active ingredients; antibacterial properties; antineoplastic activity; antineoplastic agents; breast neoplasms; butanol; cell lines; colon; cytotoxicity; diabetes; glioblastoma; herbal medicines; inhibitory concentration 50; leaves; lungs; malaria; minimum inhibitory concentration; neoplasm cells; pancreas; plant extracts; stems
Abstract:
... Helicteres hirsuta Lour. (H. hirsuta) has been considered as a herbal medicine for the treatment of malaria and diabetes but limited studies have been conducted on its anticancer and antibacterial properties. In this study, the in vitro antibacterial and anticancer properties of the leaf and stem extracts and their two sub-fractions (aqueous and saponin-enriched butanol fractions) prepared from H. ...
DOI:
10.1007/s11033-018-4370-x

9. A methanol and protic ionic liquid Ugi multicomponent reaction path to cytotoxic α-phenylacetamido amides

Author:
Sakoff, Jennette A.,   et al.   ; Al Otaibi, Ahmed; Deane, Fiona M.; Russell, Cecilia C.; Hizartzidis, Lacey; McCluskey, Siobhann N.; McCluskey, Adam;     Show all 7 Authors
Source:
RSC advances 2019 v.9 no.14 pp. 7652-7663
ISSN:
2046-2069
Subject:
aldehydes; amides; cell lines; cytotoxicity; ionic liquids; methanol; microwave radiation; moieties; neoplasm cells; neoplasms; nitrates; structure-activity relationships
Abstract:
... The Ugi four component reaction of an aldehyde, amine, isocyanide and an ethanoic acid was effected smoothly in protic ionic liquids ethylammonium nitrate (EAN) and propylammonium nitrate (PAN) to afford analogues of α-phenylacetamido amides in good to excellent isolated yields. The corresponding reactions in [BMIM][PF₆] and the protic ionic liquid ethanolammonium nitrate (ETAN) failed. Microwave ...
DOI:
10.1039/c9ra00118b

10. Phytochemical, antioxidant, anti-proliferative and antimicrobial properties of Catharanthus roseus root extract, saponin-enriched and aqueous fractions

Author:
Sakoff, Jennette A.,   et al.   ; Pham, Hong Ngoc Thuy; Vuong, Quan Van; Bowyer, Michael C.; Scarlett, Christopher J.;     Show all 5 Authors
Source:
Molecular biology reports 2019 v.46 no.3 pp. 3265-3273
ISSN:
0301-4851
Subject:
Aspergillus niger; Candida albicans; Catharanthus roseus; Enterobacter aerogenes; Escherichia coli; alkaloids; antimicrobial properties; antioxidant activity; antioxidants; apigenin; bacteria; breasts; cell lines; chemical constituents of plants; colon; cytotoxicity; fungi; gallic acid; glioblastoma; kaempferol; leaves; lungs; medicinal plants; neoplasm cells; pancreas; saponins
Abstract:
... Catharanthus roseus (L.) G. Don (C. roseus) is a well-known medicinal plant for its source of alkaloids solely found in the leaves. Other parts including the root are usually discarded after the alkaloid extraction. This study sought to investigate phytochemical profiles, antioxidant, antimicrobial and cytotoxic properties of the C. roseus root extract (RE) and its two sub-fractions including sapo ...
DOI:
10.1007/s11033-019-04786-8