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- Højfeldt, Jonas Westergaard, et al. Show all 3 Authors
- Molecular cell 2019 v.74 no.1 pp. 8-18
- catalytic activity; chromatin; functional diversity; gene expression regulation; genome; histones; lysine; methylation; methyltransferases; neoplasms; therapeutics
- ... The polycomb repressive complex 2 (PRC2) is a chromatin-associated methyltransferase catalyzing mono-, di-, and trimethylation of lysine 27 on histone H3 (H3K27). This activity is required for normal organismal development and maintenance of gene expression patterns to uphold cell identity. PRC2 function is often deregulated in disease and is a promising candidate for therapeutic targeting in canc ...