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- Kalwa, Hermann, et al. Show all 9 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2014 v.111 no.9 pp. 3383-3388
- AMP-activated protein kinase; adenosine diphosphate; antagonists; biosensors; cardiovascular diseases; cytosol; drug therapy; endothelial cells; endothelial nitric oxide synthase; endothelium; energy; fluorescence; guanosinetriphosphatase; hydrogen peroxide; image analysis; microfilaments; mitochondria; neoplasms; phospholipids; phosphorylation; receptor protein-tyrosine kinase; receptors; signal transduction; transcriptional activation; tyrosine
- ... ADP activates a family of cell surface receptors that modulate signaling pathways in a broad range of cells. ADP receptor antagonists are widely used to treat cardiovascular disease states. These studies identify a critical role for the stable reactive oxygen species hydrogen peroxide (H ₂O ₂) in mediating cellular responses activated by the G protein-coupled P2Y1 receptor for ADP. We found that A ...
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- Kalwa, Hermann, et al. Show all 5 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2011 v.108 no.38 pp. 15792-15797
- AMP-activated protein kinase; angiotensin II; cardiomyocytes; heart; hydrogen peroxide; mice; nitric oxide; nitrogen; phosphorylation
- ... Nitric oxide (NO) and hydrogen peroxide (H2O2) are synthesized within cardiac myocytes and play key roles in modulating cardiovascular signaling. Cardiac myocytes contain both the endothelial (eNOS) and neuronal (nNOS) NO synthases, but the differential roles of these NOS isoforms and the interplay of reactive oxygen species and reactive nitrogen species in cardiac signaling pathways are poorly un ...
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