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1. Ginkgo biloba Extract (EGb 761®) Inhibits Glutamate‐induced Up‐regulation of Tissue Plasminogen Activator Through Inhibition of c‐Fos Translocation in Rat Primary Cortical Neurons

Author:
Kwon, Kyoung Ja,   et al.   ; Cho, Kyu Suk; Lee, Ian Myungwon; Sim, Seobo; Lee, Eun Joo; Gonzales, Edson Luck; Ryu, Jong Hoon; Cheong, Jae Hoon; Shin, Chan Young; Han, Seol‐Heui;     Show all 10 Authors
Source:
Phytotherapy research 2016 v.30 no.1 pp. 58-65
ISSN:
0951-418X
Subject:
Alzheimer disease; Ginkgo biloba; anti-inflammatory activity; antioxidants; cell death; gene expression; gene expression regulation; leaves; messenger RNA; models; neurodegenerative diseases; neurons; neurotoxicity; rats; stroke; t-plasminogen activator; transcription (genetics); translation (genetics)
Abstract:
... EGb 761®, a standardized extract of Ginkgo biloba leaves, has antioxidant and antiinflammatory properties in experimental models of neurodegenerative disorders such as stroke and Alzheimer's disease. Tissue plasminogen activator (tPA) acts a neuromodulator and plays a crucial role in the manifestation of neurotoxicity leading to exaggerated neuronal cell death in neurological insult conditions. In ...
DOI:
10.1002/ptr.5500

2. Effects of Korean red ginseng extracts on neural tube defects and impairment of social interaction induced by prenatal exposure to valproic acid

Author:
Kwon, Kyoung Ja,   et al.   ; Kim, Pitna; Park, Jin Hee; Kim, Ki Chan; Kim, Hee Jin; Lee, Jong Min; Kim, Hahn Young; Han, Seol-Heui; Shin, Chan Young;     Show all 9 Authors
Source:
Food and chemical toxicology 2013 v.51 pp. 288-296
ISSN:
0278-6915
Subject:
Oriental traditional medicine; Panax; adverse effects; autism; dose response; humans; locomotion; medicinal plants; models; nervous system; neural tube defects; patients; phenotype; progeny; rats; tea; toxicology; valproic acid
Abstract:
... Ginseng is one of the most widely used medicinal plants, which belongs to the genus Panax. Compared to uncured white ginseng, red ginseng has been generally regarded to produce superior pharmacological effects with lesser side/adverse effects, which made it popular in a variety of formulation from tea to oriental medicine. Using the prenatal valproic acid (VPA)-injection model of autism spectrum d ...
DOI:
10.1016/j.fct.2012.10.011

3. Glucose deprivation reversibly down-regulates tissue plasminogen activator via proteasomal degradation in rat primary astrocytes

Author:
Kwon, Kyoung Ja,   et al.   ; Cho, Kyu Suk; Joo, So Hyun; Choi, Chang Soon; Kim, Ki Chan; Ko, Hyun Myung; Park, Jin Hee; Kim, Pitna; Hur, Jun; Lee, Sung Hoon; Bahn, Geon Ho; Ryu, Jong Hoon; Lee, Jongmin; Han, Seol-Heui; Shin, Chan Young;     Show all 15 Authors
Source:
Life sciences 2013 v.92 no.17-19 pp. 929-937
ISSN:
0024-3205
Subject:
Western blotting; astrocytes; brain; casein; cell viability; gene expression; gene expression regulation; glucose; messenger RNA; rats; reverse transcriptase polymerase chain reaction; signal transduction; t-plasminogen activator; translation (genetics)
Abstract:
... AIMS: Tissue plasminogen activator (tPA) is an essential neuromodulator whose involvement in multiple functions such as synaptic plasticity, cytokine-like immune function and regulation of cell survival mandates rapid and tight tPA regulation in the brain. We investigated the possibility that a transient metabolic challenge induced by glucose deprivation may affect tPA activity in rat primary astr ...
DOI:
10.1016/j.lfs.2013.03.011