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1. Huo Xue Tong Luo capsule ameliorates osteonecrosis of femoral head through inhibiting lncRNA-Miat

Author:
Lin, Dingkun,   et al.   ; Fang, Bin; Li, Ying; Chen, Chen; Wei, Qiushi; Zheng, Jiaqian; Liu, Yamei; He, Wei; Li, Gang; Hou, Yonghui; Xu, Liangliang;     Show all 11 Authors
Source:
Journal of ethnopharmacology 2019 v.238 pp. 111862
ISSN:
0378-8741
Subject:
Angelica sinensis; Carthamus tinctorius; Ligusticum; Oriental traditional medicine; RNA; alizarin; bone formation; bone marrow; femur; genes; hips; histones; mesenchymal stromal cells; osteonecrosis; osteoporosis; pathogenesis; patients; peaches; promoter regions; quantitative polymerase chain reaction; rats; staining; surgery; transcription (genetics)
Abstract:
... Traditional Chinese medicine has a long history of treating various bone diseases including osteoporosis and osteonecrosis etc. In clinical treatment, Huo Xue Tong Luo capsule (HXTL capsule) containing Peach kernel, Safflower carthamus, Angelica sinensis, Ligusticum wallichii etc, is one of the mostly used prescriptions for treating osteonecrosis of the femoral head (ONFH) with promising effects.T ...
DOI:
10.1016/j.jep.2019.111862

2. Synthesis and biological evaluation of n-butylphthalide derivatives as anti-platelet aggregation agents

Author:
Lin, Dingkun,   et al.   ; Chen, Meihui; Liu, Qi; Tan, Min; Wen, Shijun; Pi, Rongbiao;     Show all 6 Authors
Source:
Natural product research 2016 v.30 no.23 pp. 2716-2719
ISSN:
1478-6427
Subject:
adenosine; arachidonic acid; aspirin; computer software; platelet aggregation; prediction; stroke; water solubility
Abstract:
... New analogues of n-butylphthalide (NBP) bearing various lengths of alkyl and different substitution at the two-position of phthalide were designed and synthesised. Preliminary evaluation and prediction of ACD LogP software indicate that the derivatives display significant improvement in water solubility than NBP does. Further biological analysis showed that NBP analogues specifically inhibit plate ...
DOI:
10.1080/14786419.2015.1136907