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1. APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain
- Author:
- Azad Bonni, et al. ; Cole J. Ferguson; Olivia Urso; Tatyana Bodrug; Brandon M. Gassaway; Edmond R. Watson; Jesuraj R. Prabu; Pablo Lara-Gonzalez; Raquel C. Martinez-Chacin; Dennis Y. Wu; Karlla W. Brigatti; Erik G. Puffenberger; Cora M. Taylor; Barbara Haas-Givler; Robert N. Jinks; Kevin A. Strauss; Arshad Desai; Harrison W. Gabel; Steven P. Gygi; Brenda A. Schulman; Nicholas G. Brown; Show all 21 Authors
- Source:
- Molecular cell 2022 v.82 no.1 pp. 90-105.e13
- ISSN:
- 1097-2765
- Subject:
- anaphase; brain; cognition; heterochromatin; humans; mutation; neurons; proteomics; ubiquitin; ubiquitination
- Abstract:
- ... Neurodevelopmental cognitive disorders provide insights into mechanisms of human brain development. Here, we report an intellectual disability syndrome caused by the loss of APC7, a core component of the E3 ubiquitin ligase anaphase promoting complex (APC). In mechanistic studies, we uncover a critical role for APC7 during the recruitment and ubiquitination of APC substrates. In proteomics analyse ...
- DOI:
- 10.1016/j.molcel.2021.11.031
- https://doi.org/10.1016/j.molcel.2021.11.031
- Author:
- Bonni, Azad, et al. ; Yuan, Zengqiang; Becker, Esther B.E.; Merlo, Paola; Yamada, Tomoko; DiBacco, Sara; Konishi, Yoshiyuki; Schaefer, Erik M.; Show all 8 Authors
- Source:
- Science 2008 v.319 no.5870 pp. 1665-1668
- ISSN:
- 0036-8075
- Subject:
- brain; cell death; cyclin-dependent kinase; mitosis; neurons; phosphorylation; transcription (genetics); transcription factors
- Abstract:
- ... Activation of cyclin-dependent kinase 1 (Cdk1) has been linked to cell death of postmitotic neurons in brain development and disease. We found that Cdk1 phosphorylated the transcription factor FOXO1 at Ser²⁴⁹ in vitro and in vivo. The phosphorylation of FOXO1 at Ser²⁴⁹ disrupted FOXO1 binding with 14-3-3 proteins and thereby promoted the nuclear accumulation of FOXO1 and stimulated FOXO1-dependent ...
- DOI:
- 10.1126/science.1152337
- https://doi.org/10.1126/science.1152337
- Author:
- Bonni, Azad, et al. ; Shalizi, Aryaman; Gaudillière, Brice; Yuan, Zengqiang; Stegmůller, Judith; Shirogane, Takahiro; Ge, Qingyuan; Tan, Yi; Schulman, Brenda; Harper, J. Wade; Show all 10 Authors
- Source:
- Science 2006 v.311 no.5763 pp. 1012-1017
- ISSN:
- 0036-8075
- Subject:
- acetylation; calcium signaling; cerebral cortex; claws; dendrites; dephosphorylation; morphogenesis; repressor proteins; synapse; transcription (genetics)
- Abstract:
- ... Postsynaptic differentiation of dendrites is an essential step in synapse formation. We report here a requirement for the transcription factor myocyte enhancer factor 2A (MEF2A) in the morphogenesis of postsynaptic granule neuron dendritic claws in the cerebellar cortex. A transcriptional repressor form of MEF2A that is sumoylated at lysine-403 promoted dendritic claw differentiation. Activity-dep ...
- DOI:
- 10.1126/science.1122513
- https://doi.org/10.1126/science.1122513
- Author:
- Bonni, Azad, et al. ; Yang, Yue; Kim, Albert H.; Yamada, Tomoko; Wu, Bei; Bilimoria, Parizad M.; Ikeuchi, Yoshiho; de la Iglesia, Núria; Shen, Jie; Show all 9 Authors
- Source:
- Science 2009 v.326 no.5952 pp. 575-578
- ISSN:
- 0036-8075
- Subject:
- cerebral cortex; genes; mitosis; neurons; rats; signal transduction; synapse; transcription (genetics); transcription factors; ubiquitin; ubiquitin-protein ligase
- Abstract:
- ... Presynaptic axonal differentiation is essential for synapse formation and the establishment of neuronal circuits. However, the mechanisms that coordinate presynaptic development in the brain are largely unknown. We found that the major mitotic E3 ubiquitin ligase Cdc20-anaphase promoting complex (Cdc20-APC) regulates presynaptic differentiation in primary postmitotic mammalian neurons and in the r ...
- DOI:
- 10.1126/science.1177087
- PubMed:
- 19900895
- PubMed Central:
- PMC2846784
- https://doi.org/10.1126/science.1177087
- Author:
- Bonni L. Beaupied, et al. ; Heather Martinez; Sheena Martenies; Craig S. McConnel; Ilana B. Pollack; Dylan Giardina; Emily V. Fischer; Shantanu Jathar; Colleen G. Duncan; Sheryl Magzamen; Show all 10 Authors
- Source:
- Environmental research 2022 v.207 pp. 112197
- ISSN:
- 0013-9351
- Subject:
- United States Environmental Protection Agency; air; air pollution; air quality; humidity; indicator species; inflammation; milk yield; morbidity; mortality; ozone; particulates; research; smoke; somatic cell count; statistical models; summer; temperature; wildfires
- Abstract:
- ... Exposure to air pollution, including criteria pollutants such as fine particulate matter (PM₂.₅) and ozone (O₃), has been associated with morbidity and mortality in mammals. As a genetically homogenous population that is closely monitored for health, dairy cattle present a unique opportunity to assess the association between changes in air pollution and mammalian health. Milk yield decreases in th ...
- DOI:
- 10.1016/j.envres.2021.112197
- CHORUS:
- 10.1016/j.envres.2021.112197
- https://doi.org/10.1016/j.envres.2021.112197
- Author:
- Marcel Bonni, et al. ; Katharina Feld; Friederike Körber; Frank Eifinger; Sibylle Banaschak; Show all 5 Authors
- Source:
- Forensic science international 2020 v.314 pp. 110391
- ISSN:
- 0379-0738
- Subject:
- clavicle; epiphyses; femur; forensic sciences; gestational age; tibia
- Abstract:
- ... Various parameters can be used for the estimation of gestational age and maturity with arising challenges in the assessment of decomposed bodies. In order to assess gestational age and thus maturity, the study measured the femoral length, the diameter of the distal femoral epiphysis and the presence of the proximal tibial epiphysis compared to a known clavicle length. The resulting gestational age ...
- DOI:
- 10.1016/j.forsciint.2020.110391
- https://doi.org/10.1016/j.forsciint.2020.110391
- Author:
- Shirin Bonni; Azad Bonni
- Source:
- FEBS letters 2012 v.586 no.14 pp. 1977-1983
- ISSN:
- 0014-5793
- Subject:
- brain; cell cycle; mammals; neurons; neurophysiology; signal transduction; tissues; transcription factors; transforming growth factor beta
- Abstract:
- ... The transcriptional regulator SnoN plays a fundamental role as a modulator of transforming growth factor beta (TGFβ)-induced signal transduction and biological responses. In recent years, novel functions of SnoN have been discovered in both TGFβ-dependent and TGFβ-independent settings in proliferating cells and postmitotic neurons. Accumulating evidence suggests that SnoN plays a dual role as a co ...
- DOI:
- 10.1016/j.febslet.2012.02.048
- PubMed:
- 22710173
- PubMed Central:
- PMC3383335
- https://doi.org/10.1016/j.febslet.2012.02.048
- Author:
- Gustave Bonni, et al. ; Pierre Jean Silvie; Alain Renou; Samuel Vodounnon; Moïse Obayomi Adegnika; Omer Héma; Patrick Prudent; Julie Sorèze; Germain Ochou Ochou; Mamoutou Togola; Djibril Badiane; Abdoulaye Ndour; Pikassalé Komlan Akantetou; Bassarou Ayeva; Thierry Brévault; Show all 15 Authors
- Source:
- Crop protection 2013 v.43 pp. 157-165
- ISSN:
- 0261-2194
- Subject:
- Aphis gossypii; Diparopsis; Earias insulana; Gossypium hirsutum; Helicoverpa armigera; Polyphagotarsonemus latus; Thaumatotibia; bolls; cotton; insect larvae; insecticides; mites; pest control; pest monitoring; pesticide application; pests; plant protection; Benin; Burkina Faso; Cameroon; Cote d'Ivoire; Mali; Senegal
- Abstract:
- ... In the late 1980s, after a long period during which insecticides were sprayed at preset dates to control cotton (Gossypium hirsutum L.) pests and their damage, some French-speaking countries in sub-Saharan areas decided to disseminate a special form of crop protection approach among smallholders, i.e. targeted staggered control (LEC, for Lutte étagée ciblée). According to this approach, decisions ...
- DOI:
- 10.1016/j.cropro.2012.09.006
- https://doi.org/10.1016/j.cropro.2012.09.006
- Author:
- Bonni, Azad, et al. ; Ramos, Belén; Gaudillière, Brice; Gill, Grace; Show all 4 Authors
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.23 pp. 9882-9887
- ISSN:
- 0027-8424
- Subject:
- DNA-binding domains; cerebral cortex; dendrites; gene overexpression; mammals; mutants; pruning; resorption; transcription factors
- Abstract:
- ... Integration of inputs by a neuron depends on dendritic arborization patterns. In mammals, the genetic programs that regulate dynamic remodeling of dendrites during development and in response to activity are incompletely understood. Here we report that knockdown of the transcription factor Sp4 led to an increased number of highly branched dendrites during maturation of cerebellar granule neurons i ...
- DOI:
- 10.1073/pnas.0701946104
- PubMed:
- 17535924
- PubMed Central:
- PMC1887555
- https://doi.org/10.1073/pnas.0701946104