Jump to Main Content
- H.-Christian von BÃ¼dingen, et al. Show all 13 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2011 v.108 no.50 pp. 20066-20071
- risk; sequence analysis; immunogenetics; antibody formation; humoral immunity; antibodies; lymphocytes; genetic background; immunotherapy; variance; genes; twins; inheritance (genetics); genetic variation; heritability; environmental exposure
- ... A diverse antibody repertoire is essential for an effective adaptive immune response to novel molecular surfaces. Although past studies have observed common patterns of V-segment use, as well as variation in V-segment use between individuals, the relative contributions to variance from genetics, disease, age, and environment have remained unclear. Using high-throughput sequence analysis of monozyg ...
- PubMed Central: