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1. Difference in the PK of ceftiofur in the presence and absence of nimesulide and implications for dose determination through PK/PD integration

Author:
Daundkar, Prashant S.,   et al.   ; Sidhu, Pritam Kaur; Waraich, Gauravdeep Singh; Kaur, Gurpreet; Sharma, Suresh Kumar; Gehring, Ronette;     Show all 6 Authors
Source:
Small ruminant research 2018 v.159 pp. 18-25
ISSN:
0921-4488
Subject:
absorption; adults; antibacterial properties; bacteria; blood sampling; ceftiofur; cross-over studies; goat diseases; goats; growth retardation; half life; infectious diseases; jugular vein; mutants; pharmacodynamics; pharmacokinetics
Abstract:
... The study was planned to determine the pharmacokinetic (PK) and pharmacodynamic (PD) interactions between ceftiofur crystalline free acid (CCFA) and nimesulide (NS). The CCFA was administered to six adult non-lactating goats alone and in combination with NS in a two period cross-over study so that each goat receives each treatment. CCFA (6.6 mg/kg) and NS (2 mg/kg) were injected SC and IM, respect ...
DOI:
10.1016/j.smallrumres.2017.12.005

2. Histopathological and morphological studies on natural Cysticercus fasciolaris infection in liver of Wistar rats

Author:
Daundkar, Prashant S.,   et al.   ; Moudgil, Aman Dev; Singla, Lachhman Das; Gupta, Kuldip; Vemu, Bhaskar;     Show all 5 Authors
Source:
Journal of parasitic diseases 2016 v.40 no.2 pp. 255-258
ISSN:
0971-7196
Subject:
Taenia taeniaeformis; granulation tissue; histopathology; inflammation; intestines; liver; metacestodes; metaplasia; parasitoses; rats; stomach
Abstract:
... Descriptive morphology of multifocal hepatic cysts found in eight of forty five (17.78 %) Wistar rats sacrificed during pharmacological studies related to herbal formulations was studied. The creamish to white cysts were of varying sizes, ranging from 3–8 mm in diameter. Morphological studies of these cysts depicted the presence of metacestodes of Taenia taeniaeformis i.e. Cysticercus fasciolaris ...
DOI:
10.1007/s12639-014-0488-5
PubMed:
27413289
PubMed Central:
PMC4927470

3. In vitro acaricidal activity of Murraya koenigii (L.) Spreng (Rutaceae) extracts against synthetic pyrethroid-resistant Rhipicephalus (Boophilus) microplus

Author:
Daundkar, Prashant S.,   et al.   ; Singh, Nirbhay Kumar; Jyoti,; Vemu, Bhaskar; Singh, Harkirat; Prerna, Mranalini; Sharma, S. K.; Dumka, V. K.;     Show all 8 Authors
Source:
Parasitology research 2015 v.114 no.4 pp. 1531-1539
ISSN:
0932-0113
Subject:
ticks; oviposition; Rhipicephalus microplus; pyrethrins; egg weight; acaricidal properties; deltamethrin; lethal concentration 50; chloroform; Bergera koenigii; adults; acetone; hatching; hexane; females; leaves; larvae; eggs; ethanol; mortality; cypermethrin; India
Abstract:
... Larval packet test was used for detection of resistance status against cypermethrin and deltamethrin, the most commonly used synthetic pyrethroids in Rhipicephalus (Boophilus) microplus collected from Faridkot district, Punjab (India). The slope of mortality, lethal concentration for 50 % (LC₅₀) and resistance levels were determined from the regression graphs of probit mortality of ticks plotted a ...
DOI:
10.1007/s00436-015-4337-y