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- Author:
- Fernandes, João B., et al. ; Pereira, Luciane G Batista; Petacci, Fernando; Corrêa, Arlene G.; Vieira, Paulo C.; Silva, M Fátima G F da; Malaspina, Osmar; Show all 7 Authors
- Source:
- Pest management science 2002 v.58 no.5 pp. 503-507
- ISSN:
- 1526-498X
- Subject:
- Anticarsia gemmatalis; Dimorphandra; Spodoptera frugiperda; ingestion; insecticidal properties; larvae; nuclear magnetic resonance spectroscopy; pest management; stomach; weight loss
- Abstract:
- ... Astilbin was isolated in high yield from Dimorphandra mollis, and its insecticidal and growth inhibiting activity by stomach ingestion were evaluated against Anticarsia gemmatalis and Spodoptera frugiperda. The insecticidal activity of astilbin, the weight reduction of the larval phase and the prolongation of the larval and pupal phases were verified for both species. Astilbin was identified on th ...
- DOI:
- 10.1002/ps.478
- http://dx.doi.org/10.1002/ps.478
- Author:
- Fernandes, João B., et al. ; Gallo, Margareth B.C.; Vieira, Paulo C.; da Silva, Maria Fátima das G.F.; Salimena-Pires, Fátima R.; Show all 5 Authors
- Source:
- Journal of ethnopharmacology 2008 v.115 no.2 pp. 320-322
- ISSN:
- 0378-8741
- Subject:
- anti-inflammatory activity; fractionation; methanol; flavones; medicinal plants; plant extracts; chromatography; isomers; leaves; solvents; hexane; kidney diseases; Vitex; antioxidant activity; antioxidants; herbal medicines; analgesic effect; Brazil
- Abstract:
- ... Vitex polygama Cham. (Lamiaceae, formerly Verbenaceae) is a familiar Brazilian species popularly known as Tarumã whose leaf tea has been used by population to treat kidney diseases. The aim of this research was to investigate the hydroalcoholic extract of leaves in order to isolate the active compounds. Hydroalcoholic extract of leaves was obtained by stirring the previous hexane and methanol extr ...
- DOI:
- 10.1016/j.jep.2007.09.020
- http://dx.doi.org/10.1016/j.jep.2007.09.020
- Author:
- Fernandes, João B., et al. ; Ribeiro, Alan Bezerra; Abdelnur, Patrícia Verardi; Garcia, Cleverson Fernando; Belini, Adriana; Severino, Vanessa G. Pasqualotto; Silva, M. Fátima das G.F. da; Vieira, Paulo C.; Carvalho, Sérgio A. de; Souza, Alessandra A. de; Machado, Marcos A.; Show all 11 Authors
- Source:
- Journal of agricultural and food chemistry 2008 v.56 no.17 pp. 7815-7822
- ISSN:
- 0021-8561
- Subject:
- chemical analysis; chemical composition; Citrus sinensis; grafting (plants); Citrus limonia; chemical compounds; plant growth; Xylella fastidiosa; Pierce's disease; disease control
- Abstract:
- ... Citrus sinensis grafted on C. limonia produces a considerable number of compounds that are not common in both plants developed from germination of seeds. The chemical profile of scion and rootstock differ notably for absence in the form of flavonoids and coumarins containing C5 prenyl groups attached to the carbon atoms of aromatic and heterocyclic systems or to oxygen. Only linear pyranocoumarins ...
- DOI:
- 10.1021/jf801103p
- PubMed:
- 18683948
- http://dx.doi.org/10.1021/jf801103p
4. Limonoids of the Phragmalin Type from Swietenia macrophylla and Their Chemotaxonomic Significance
- Author:
- Fernandes, Joao B., et al. ; Silva, Milton Nascimento da; Arruda, Mara Silvia Pinheiro; Castro, Kelly Christina F.; Silva, M. Fatima das G. F. da; Vieira, Paulo C.; Show all 6 Authors
- Source:
- Journal of natural products 2008 v.71 no.12 pp. 1983-1987
- ISSN:
- 0163-3864
- Subject:
- Swietenia macrophylla; limonoids; chemical structure; spectral analysis; chemotaxonomy; plant taxonomy; Brazil
- DOI:
- 10.1021/np800312h
- PubMed:
- 19053509
- http://dx.doi.org/10.1021/np800312h
- Author:
- Fernandes, João B., et al. ; Reche, Karine V.G.; Souza, Gezimar D. de; Trapp, Marília A.; Rodrigues-Filho, Edson; Silva, Sebastião C.; Vieira, Paulo C.; Muller, Manfred W.; Silva, M. Fátima das G.F. da; Show all 9 Authors
- Source:
- Phytochemistry 2009 v.70 no.17-18 pp. 2027-2033
- ISSN:
- 0031-9422
- Subject:
- Khaya ivorensis; secondary metabolites; limonoids; disease resistance; resistance mechanisms; Botryosphaeria; plant pathogenic fungi; host-pathogen relationships
- Abstract:
- ... Khaya ivorensis with and without symptoms of stem and branch cankers, caused by Botryosphaeria rhodina were examined in order to determine whether the secondary metabolites in this plant were associated with a chemical defense response. This study provides evidence that the limonoid methyl angolensate (MA) is present at higher concentrations in K. ivorensis with symptoms of stem cankers rather tha ...
- DOI:
- 10.1016/j.phytochem.2009.08.013
- PubMed:
- 19765786
- http://dx.doi.org/10.1016/j.phytochem.2009.08.013
- Author:
- Fernandes, João B., et al. ; Forim, Moacir Rossi; Cornélio, Vivian Estevam; das G. F. da Silva, M. Fátima; Rodrigues-Filho, Edson; Vieira, Paulo C.; Matinez, Sueli Souza; Napolitano, Michael P.; Yost, Richard A.; Show all 9 Authors
- Source:
- Phytochemical analysis 2010 v.21 no.4 pp. 363-373
- ISSN:
- 0958-0344
- Subject:
- Azadirachta indica; Melia azedarach; aerial parts; azadirachtin; bark; climate; flowers; fruits; leaves; limonoids; oilseeds; roots; rootstocks; seeds; stems; trees; vegetative propagation
- Abstract:
- ... Introduction - Melia azedarach adapted to cool climates was selected as rootstocks for vegetative propagation of Azadirachta indica. Cleft grafting of A. indica on M. azedarach rootstock showed excellent survival. Little is known about the chemistry of grafting.Objective - The roots, stems, leaves and seeds of this graft were examined in order to verify if grafted A. indica would produce limonoids ...
- DOI:
- 10.1002/pca.1208
- PubMed:
- 20333612
- http://dx.doi.org/10.1002/pca.1208
- Author:
- Fernandes, Joao B., et al. ; Castral, Thais C.; Matos, Andreia P.; Monteiro, Julia L.; Araujo, Fernanda M.; Bondancia, Tatiani M.; Batista-Pereira, Luciane G.; Vieira, Paulo C.; Silva, M. Fatima G.F. da; Correa, Arlene G.; Show all 10 Authors
- Source:
- Journal of agricultural and food chemistry 2011 v.59 no.9 pp. 4822–4827
- ISSN:
- 0021-8561
- Subject:
- Spodoptera frugiperda; amides; corn; crops; ingestion; lethal dose 50; mortality; pesticides; pests; transgenic plants
- Abstract:
- ... The fall armyworm Spodoptera frugiperda is a polyphagous pest that causes important damage in different regions of America and mainly affects corn crops in both tropical and subtropical areas. Currently, control relies on both transgenic plants and/or chemical pesticides. In this work we describe the preparation of an indexed combinatorial library of amides and its toxic effect by contact against ...
- DOI:
- 10.1021/jf104903t
- PubMed:
- 21443174
- http://dx.doi.org/10.1021/jf104903t
- Author:
- Fernandes, João B., et al. ; dos Santos, Karen C.; da Silva, Maria Fátima G. F.; Vieira, Paulo C.; Polikarpov, Igor; Zucolotto, Valtencir; Forim, Moacir R.; Show all 7 Authors
- Source:
- Analytical methods 2011 v.3 no.9 pp. 1936-1942
- ISSN:
- 1759-9679
- Subject:
- acetonitrile; lactones; nanoparticles; pH; polyhydroxybutyrate; polymethylmethacrylate; reversed-phase high performance liquid chromatography; temperature; thyroid hormones; triethylamine; wavelengths
- Abstract:
- ... The objective of this work was to develop and validate a rapid Reversed-Phase High-Performance Liquid Chromatography method for the quantification of 3,5,3′-triiodothyroacetic acid (TRIAC) in nanoparticles delivery system prepared in different polymeric matrices. Special attention was given to developing a reliable reproductive technique for the pretreatment of the samples. Chromatographic runs we ...
- DOI:
- 10.1039/c1ay05169e
- http://dx.doi.org/10.1039/c1ay05169e
- Author:
- Fernandes, João B., et al. ; Severino, Vanessa G.P.; Braga, Patrícia A.C.; da Silva, Maria Fátima das G.F.; Vieira, Paulo C.; Theodoro, Jahyr E.; Ellena, Javier A.; Show all 7 Authors
- Source:
- Phytochemistry 2012 v.76 pp. 52-59
- ISSN:
- 0031-9422
- Subject:
- Flindersia; limonoids; methylene chloride; stems; taxonomy
- Abstract:
- ... The dichloromethane extract from taproots of Hortia oreadica afforded six limonoids, these are 9,11-dehydro-12α-acetoxyhortiolide A, hortiolide C, 11α-acetoxy-15-deoxy-6-hydroxyhortiolide C, hortiolide D, hortiolide E, 12β-hydroxyhortiolide E, in addition to the known limonoid, guyanin. The dichloromethane extract from stems of H. oreadica also afforded two limonoids 9,11-dehydro-12α-hydroxyhortio ...
- DOI:
- 10.1016/j.phytochem.2011.12.016
- PubMed:
- 22289621
- http://dx.doi.org/10.1016/j.phytochem.2011.12.016
- Author:
- Fernandes, João B., et al. ; Nebo, Liliane; Varela, Rosa M.; Molinillo, José M.G.; Sampaio, Olívia M.; Severino, Vanessa G.P.; Cazal, Cristiane M.; Fernandes, Maria Fátima das Graças; Macías, Francisco A.; Show all 9 Authors
- Source:
- Phytochemistry letters 2014 v.8 pp. 226-232
- ISSN:
- 1874-3900
- Subject:
- Allium cepa; Lactuca sativa; Lepidium sativum; Meliaceae; Rutaceae; Solanum lycopersicum var. lycopersicum; alkaloids; allelochemicals; allelopathy; bioassays; coleoptiles; flavonoids; herbicides; lettuce; onions; phytotoxicity; psoralen; secondary metabolites; tomatoes; wheat
- Abstract:
- ... Meliaceae and Rutaceae families are known for the high diversity of their secondary metabolites, which include many groups that represent a rich source of structural diversity, and are good candidates as sources of allelochemicals that could be useful in agriculture. In the work described here the bioactivity profiles were evaluated for 3 alkaloids (1–3), 12 coumarins (4–15), 2 phenylpropanoic aci ...
- DOI:
- 10.1016/j.phytol.2014.02.010
- https://dx.doi.org/10.1016/j.phytol.2014.02.010
- Author:
- Fernandes, João B., et al. ; Moreira, Ariele C.; Ferreira, Douglas; de Almeida, Fernando G.; Rodrigues-Filho, Edson; Silva, Maria F. G. F.; Vieira, Paulo C.; Pagnocca, Fernando C.; Souza, Dulce Helena F.; Show all 9 Authors
- Source:
- Applied biochemistry and biotechnology 2014 v.173 no.3 pp. 694-704
- ISSN:
- 0273-2289
- Subject:
- Leucoagaricus; enzyme activity; fungi; molecular weight; pH; temperature; xylanases
- Abstract:
- ... In this work, the xylanolytic profile of Leucoagaricus gongylophorus was studied, and two extracellular enzymes with xylanolytic activity (XyLg1 and XyLg2) were isolated, purified, and characterized. XyLg1 has a molecular mass of about 38 kDa and pI greater than 4.8. For beechwood xylan substrate, XyLg1 showed an optimum temperature of 40 °C, optimum pH between 8.5 and 10.5, and Km = 14.7 ± 7.6 mg ...
- DOI:
- 10.1007/s12010-014-0872-8
- PubMed:
- 24699813
- http://dx.doi.org/10.1007/s12010-014-0872-8
- Author:
- Fernandes, João B., et al. ; de Souza, Rejane C.; Vieira, Paulo C.; da Silva, M. Fátima das G. F.; Godoy, Marizete F. P.; Pagnocca, Fernando C.; Bueno, Odair C.; Hebling, M. José A.; Pirani, José R.; Show all 9 Authors
- Source:
- Zeitschrift für Naturforschung 2014 v.60 no.7 pp. 787-791
- ISSN:
- 0932-0776
- Subject:
- Atta sexdens rubropilosa; Leucoagaricus; Pilocarpus; alkaloids; antifungal properties; fungi; leaf-cutting ants; quinolones; scopoletin; spectral analysis; stems; syringic acid; vanillic acid
- Abstract:
- ... The stems of Pilocarpus grandiflorus have afforded the new imidazole alkaloid 4,6-dehydro- 1,2,4,5-tetrahydro-2,5-dioxopilocarpine in addition to the 17 known compounds germanicol, β - amiryn, ocotillone, stigmast-4-en-3-one, 3β -hydroxy-stigmast-5-en-7-one, 6β -hydroxy-stigmast-4- en-3-one, β -sitosterol, scopoletin, 3-(1’,1’-dimethylallyl)-scopoletin, elisin, dictamine, 4-methoxy-2- quinolone, p ...
- DOI:
- 10.1515/znb-2005-0715
- http://dx.doi.org/10.1515/znb-2005-0715
- Author:
- Fernandes, João B., et al. ; Batista-Pereira, Luciane G.; dos Santos, Márcio G.; Corrêa, Arlene G.; Arab, Alberto; Costa-Leonardo, Ana Maria; Dietrich, Célia R. R. C.; Pereira, Dilmar A.; Bueno, Odair C.; Show all 9 Authors
- Source:
- Zeitschrift für Naturforschung 2014 v.59 no.1-2 pp. 135-139
- ISSN:
- 0939-5075
- Subject:
- Eucalyptus; Heterotermes; Pinus; alkanes; alkenes; antennae; electroantennography; electrophysiology; gas chromatography-mass spectrometry; habitats; imagos; insects; odors; pests; social behavior; sugarcane; traps
- Abstract:
- ... Termites have become an important pest of Eucalyptus and Pinus reforestations, sugarcane and other cultures. An alternative for the control of this pest would be the use of attractive traps that take in account the social behavior of these insects. Diverse factors are important for the insects in the localization of the habitat and the choice of the food and specific odors can facilitate this. Stu ...
- DOI:
- 10.1515/znc-2004-1-226
- http://dx.doi.org/10.1515/znc-2004-1-226
- Author:
- Fernandes, João B., et al. ; Sarria, André L. F; Soares, Márcio S.; Matos, Andréia P.; Vieira, Paulo C.; Silva, M. Fátima das G. F. da; Show all 6 Authors
- Source:
- Zeitschrift für Naturforschung 2014 v.66 no.5-6 pp. 245-250
- ISSN:
- 1865-7125
- Subject:
- Cabralea canjerana; Carapa guianensis; Spodoptera frugiperda; fruits; insecticidal properties; larvae; limonoids; pupae; seeds
- Abstract:
- ... The activities of two triterpenoids, ocotillone and cabraleadiol, and four limonoids, methyl angolensate, 3-β-deacetylfi ssinolide, 7-deacetoxy-7-oxogedunin, and β-photogedunin, isolated from arillus of Carapa guianensis and fruits and seeds of Cabralea canjerana (Meliaceae), were evaluated against the fall armyworm Spodoptera frugiperda. Gedunin was used as a positive control. 7-Deacetoxy-7-oxoge ...
- DOI:
- 10.1515/znc-2011-5-607
- http://dx.doi.org/10.1515/znc-2011-5-607
- Author:
- Fernandes, João B., et al. ; Matos, Andreia P.; Leite, Ana C.; Batista-Pereira, Luciane G.; Vieira, Paulo C.; Silva, Maria Fátima das G. F. da; Show all 6 Authors
- Source:
- Zeitschrift für Naturforschung 2014 v.64 no.5-6 pp. 441-446
- ISSN:
- 1865-7125
- Subject:
- Meliaceae; Spodoptera frugiperda; antifeeding activity; artificial diets; chemical structure; fruits; growth retardation; insecticidal properties; limonoids; methylene chloride; mortality; neonates
- Abstract:
- ... Six mexicanolide limonoids isolated from the dichloromethane extract of the fruits of Cipadessa fruticosa Blume (Meliaceae) were evaluated against Spodoptera frugiperda (J. E. Smith). Gedunin was used as a positive control. When incorporated into an artificial diet of neonates at 50.0 mg kg⁻¹, febrifugin A showed 73.3% mortality. All the compounds showed moderate insecticidal activity, except for ...
- DOI:
- 10.1515/znc-2009-5-623
- http://dx.doi.org/10.1515/znc-2009-5-623
- Author:
- Fernandes, João B., et al. ; Batista-Pereira, Luciane G.; Silva, M. Fátima G. F. da; Vieira, Paulo C.; Bueno, Odair C.; Corrêa, Arlene G.; Show all 6 Authors
- Source:
- Zeitschrift für Naturforschung 2014 v.61 no.9-10 pp. 749-755
- ISSN:
- 1865-7125
- Subject:
- Atta sexdens rubropilosa; Eucalyptus; allelochemicals; antennae; chemical composition; defoliation; electroantennography; electrophysiology; essential oils; foraging; leaf-cutting ants; pests; receptors; terpenoids; volatile compounds; wood; worker ants
- Abstract:
- ... The leaf-cutting ant Atta sexdens rubropilosa Forel, 1908 is the most harmful of the Eucalyptus pests, causing severe losses in wood production through defoliation. Various strategies have been tried and effort spent on the development of methods to control this pest, however no practical and environmentally acceptable one currently exists. In this work the chemical composition of the essential oi ...
- DOI:
- 10.1515/znc-2006-9-1023
- http://dx.doi.org/10.1515/znc-2006-9-1023
- Author:
- Fernandes, João B., et al. ; Gallo, Margareth B. C.; Marques, Anna Sylvia F.; Vieira, Paulo C.; da Silva, Maria Fátima das G. F.; Silva, Márcio; Guido, Rafael V.; Oliva, Glaucius; Thiemann, Otávio H.; Albuquerque, Sérgio; Fairlamb, Alan H.; Show all 11 Authors
- Source:
- Zeitschrift für Naturforschung 2014 v.63 no.5-6 pp. 371-382
- ISSN:
- 1865-7125
- Subject:
- Leishmania; Myrtaceae; Trypanosoma cruzi; Verbenaceae; Vitex; bioassays; bloodstream forms; glyceraldehyde-3-phosphate dehydrogenase
- Abstract:
- ... Hexanic, methanolic, and hydroalcoholic extracts, and 34 isolated compounds from Vitex polygama Cham. (Lamiaceae, formely Verbenaceae) and Siphoneugena densiflora O. Berg (Myrtaceae) were screened for their trypanocidal effects on bloodstream forms of Trypanosoma cruzi and T. brucei, as well as for their enzymatic inhibitory activities on glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH ...
- DOI:
- 10.1515/znc-2008-5-611
- http://dx.doi.org/10.1515/znc-2008-5-611
- Author:
- Fernandes, João B., et al. ; Batista-Pereira, Luciane G; Castral, Thais C.; Silva, Marina T. M. da; Amaral, Bruna R.; Vieira, Paulo C.; Silva, M. Fatima G. F. da; Corrêa, Arlene G.; Show all 8 Authors
- Source:
- Zeitschrift für Naturforschung 2014 v.61 no.3-4 pp. 196-202
- ISSN:
- 1865-7125
- Subject:
- Piper; Spodoptera frugiperda; amides; ingestion; insecticidal properties; larvae; lethal dose 50; piperidines; plant biochemistry
- Abstract:
- ... The phytochemistry of the genus Piper (Piperaceae) has been widely studied due to the biological properties of amides from these plants. In this work, we have synthesized and evaluated the toxic effect of 11 amides against the fall armyworm Spodoptera frugiperda larvae. The naturally occurring piperine was also evaluated. The most active amide was N- [3-(3′,4′-methylenedioxyphenyl)-2-(E)-propenoyl ...
- DOI:
- 10.1515/znc-2006-3-408
- http://dx.doi.org/10.1515/znc-2006-3-408
- Author:
- Fernandes, João B., et al. ; Lião, Luciano M.; Vieira, Paulo C.; Rodrigues-Filho, Edson; Silvab, Maria F. G. F.; Show all 5 Authors
- Source:
- Zeitschrift für Naturforschung 2014 v.57 no.3-4 pp. 403-406
- ISSN:
- 0939-5075
- Subject:
- Celastraceae; carbon; methanol; roots; spectral analysis; triterpenoids
- Abstract:
- ... An investigation of the MeOH extract from the roots of Peritassa campestris (Hippocrateaceae) afforded two isomeric seco-A-ring quinonemethide triterpenoids, campestrine-I (1) and -II (2). This appears to be the first report of a C₂₆-type triterpene carbon skeleton from the Celastraceae or Hippocrateaceae families. The structures were elucidated on the basis of spectral data, particularly HMQC, HM ...
- DOI:
- 10.1515/znc-2002-3-433
- http://dx.doi.org/10.1515/znc-2002-3-433
- Author:
- Fernandes, João B., et al. ; Leite, Ana C.; da Silva, M. Fátima das G. F.; Vieira, Paulo C.; Show all 4 Authors
- Source:
- Zeitschrift für Naturforschung 2014 v.60 no.3 pp. 351-355
- ISSN:
- 0932-0776
- Subject:
- Cipadessa; fruits; limonoids; spectroscopy
- Abstract:
- ... The fruits of Cipadessa fruticosa Bl. afforded two new limonoids: methyl 8α,30α-epoxide-3β - (2’-methylbutyryloxy)-1-oxomeliacate (cipadesin A) and methyl 21,23-dihydro-23-hydroxy-21-oxo- 3β -tigloyloxy-1-oxomeliac-8(30)-enate (febrifugin A), along with the known limonoids cipadesin, khayasin T, febrifugin, ruageanin A and mexicanolide. Their structures were elucidated on the basis of spectroscopi ...
- DOI:
- 10.1515/znb-2005-0321
- http://dx.doi.org/10.1515/znb-2005-0321
- Author:
- Fernandes, João B., et al. ; Biavatti, Maique W.; Vieira, Paulo C.; Silva, M. Fatima G. F. da; Albuquerque, Sérgio; Show all 5 Authors
- Source:
- Zeitschrift für Naturforschung 2014 v.56 no.7-8 pp. 570-574
- ISSN:
- 1865-7125
- Subject:
- Rutaceae; Trypanosoma cruzi; bioactive properties; leaves; limonin; limonoids; stems; surveys
- Abstract:
- ... Phytochemical survey of stems and leaves of the South Brazilian endemic Raulinoa echinata Cowan, Rutaceae led to the isolation of five limonoid derivatives: the widespread limonin, limonexic acid, kihadalactone B, a methoxylated limonexic acid derivative and a degraded limonoid structurally related to fraxinellone. The two latter compounds have been isolated for the first time. These compounds dis ...
- DOI:
- 10.1515/znc-2001-7-815
- http://dx.doi.org/10.1515/znc-2001-7-815
- Author:
- Fernandes, João B., et al. ; Tanoli, Sheraz A. K.; Tanoli, Nazish U.; Bondancia, Tatiani M.; Usmani, Saman; Ul-Haq, Zaheer; Thomasi, Sérgio S.; Ferreira, Antonio G.; Show all 8 Authors
- Source:
- RSC advances 2015 v.5 no.30 pp. 23431-23442
- ISSN:
- 2046-2069
- Subject:
- Stryphnodendron; active sites; epitopes; herbal medicines; human serum albumin; ligands; molecular weight; nuclear magnetic resonance spectroscopy; protons; rapid methods; screening; Brazil
- Abstract:
- ... Over the last two decades, new and more advanced strategies that help in the rapid screening and identification of new ligands for a specific macromolecule have become an important domain. From this viewpoint, the effectiveness of STD NMR, Tr-NOESY, and STD-TOCSY has been utilized to evaluate the binding potential of the natural extract of Stryphnodendron polyphyllum, used as a herbal medicine in ...
- DOI:
- 10.1039/c5ra01457c
- http://dx.doi.org/10.1039/c5ra01457c
- Author:
- Fernandes, João B., et al. ; Cornelio, Vivian E.; Pedroso, Mariele M.; Afonso, André S.; da Silva, M.Fátima G.F.; Faria, Ronaldo C.; Vieira, Paulo C.; Show all 7 Authors
- Source:
- Analytica chimica acta 2015 v.862 pp. 86-93
- ISSN:
- 0003-2670
- Subject:
- analytical chemistry; biosensors; cathepsin D; drug therapy; enzymatic reactions; erythrocytes; hemoglobin; humans; hydrolysis; monitoring; parasites; quartz; screening; spectrophotometers
- Abstract:
- ... The hemoglobin (Hb) released from erythrocytes is a primary nutritive component for many blood-feeding parasites. The aspartic protease cathepsin D is a hemoglobinase that is involved in the Hb degradation process and is considered an interesting target for chemotherapy intervention. However, traditional enzymatic assays for studying Hb degradation utilize spectrophotometric techniques, which do n ...
- DOI:
- 10.1016/j.aca.2015.01.003
- http://dx.doi.org/10.1016/j.aca.2015.01.003
- Author:
- Fernandes, João B., et al. ; de Sousa, Lorena R.F.; Wu, Hongmei; Nebo, Liliane; da Silva, Maria F. das G.F.; Kiefer, Werner; Schirmeister, Tanja; Vieira, Paulo C.; Show all 8 Authors
- Source:
- Experimental parasitology 2015 v.156 pp. 42-48
- ISSN:
- 0014-4894
- Subject:
- Leishmania mexicana; antileishmanial properties; cathepsin L; drugs; inhibitory concentration 50; leishmaniasis; mammals; mechanism of action; parasites; quercetin; triterpenoids; virulence
- Abstract:
- ... Cysteine proteinases (cathepsins) from Leishmania spp. are promising molecular targets against leishmaniasis. Leishmania mexicana cathepsin L is essential in the parasite life cycle and a pivotal in virulence factor in mammals. Natural products that have been shown to display antileishmanial activity were screened as part of our ongoing efforts to design inhibitors against the L. mexicana cathepsi ...
- DOI:
- 10.1016/j.exppara.2015.05.016
- http://dx.doi.org/10.1016/j.exppara.2015.05.016
- Author:
- Fernandes, João B., et al. ; Ramalho, Suelem D.; de Sousa, Lorena R. F.; Burger, Marcela C. M.; Lima, Maria Inês S.; da Silva, M. Fátima das G. F.; Vieira, Paulo C.; Show all 7 Authors
- Source:
- Natural product research 2015 v.29 no.23 pp. 2212-2214
- ISSN:
- 1478-6427
- Subject:
- Myrtaceae; cathepsin B; cerrado; ecosystems; fractionation; humans; inhibitory concentration 50; myricetin; neoplasms; quercetin
- Abstract:
- ... Cathepsin B (catB) is a cysteine protease involved in tumour progression and represents a potential therapeutic target in cancer. Among the 15 evaluated extracts from cerrado biome, Myrcia lingua Berg. (Myrtaceae) extract demonstrated to be a source of compounds with potential to inhibit catB. Using bioactivity-guided fractionation, we have found flavonols as inhibitors and also some other derivat ...
- DOI:
- 10.1080/14786419.2014.1002404
- http://dx.doi.org/10.1080/14786419.2014.1002404
- Author:
- Fernandes, João B., et al. ; Souza, Camila M.; Baldin, Edson L. L.; Ribeiro, Leandro P.; Silva, Ivana F.; Morando, Rafaela; Bicalho, Keylla U.; Vendramim, José D.; Show all 8 Authors
- Source:
- Journal of pest science 2017 v.90 no.2 pp. 701-709
- ISSN:
- 1612-4758
- Subject:
- Annona squamosa; Helicoverpa armigera; Neotropics; active ingredients; acute toxicity; bioassays; biopesticides; chromatography; dietary exposure; flubendiamide; greenhouse experimentation; insecticides; larvae; larval development; lethal concentration 50; mortality; mucosa; screening; seeds; tomatoes
- Abstract:
- ... Among tropical plant families, members of Annonaceae have great potential as a source of biopesticides. To develop an alternative tool for control of Helicoverpa armigera, efficacy of ethanolic extracts from seeds of five species belonging to the genus Annona (A. montana Macfad., A. mucosa Jacq., A. muricata L., A. reticulata L. and A. sylvatica A. St.-Hil.) and an acetogenin-based commercial bioi ...
- DOI:
- 10.1007/s10340-016-0817-9
- http://dx.doi.org/10.1007/s10340-016-0817-9
- Author:
- Fernandes, João B., et al. ; Perlatti, Bruno; Luiz, Anderson L.; Prieto, Evandro L.; da Silva, Maria Fátima das Graças Fernandes; Ferreira, Douglas; Costa, Eduardo N.; Boiça Júnior, Arlindo L.; Forim, Moacir R.; Show all 9 Authors
- Source:
- Agricultural and forest entomology 2017 v.19 no.4 pp. 408-417
- ISSN:
- 1461-9555
- Subject:
- Diabrotica speciosa; Enterobacteriales; Pseudomonadales; bacteria; cluster analysis; crops; desorption; digestive system; genes; genomics; insect pests; intestinal microorganisms; ionization; matrix-assisted laser desorption-ionization mass spectrometry; pest control; proteomics; rearing; ribosomal RNA; sequence analysis; South America
- Abstract:
- ... Resistance development in pest insects has guided the advance of cleaner and more effective strategies for pest control. An interesting and promising strategy is the manipulation of insects via their gut microbiota. To evaluate the feasibility of this strategy, Diabrotica speciosa, a highly polyphagous pest insect from South America that causes substantial damage to several important crops, was re ...
- DOI:
- 10.1111/afe.12220
- http://dx.doi.org/10.1111/afe.12220
- Author:
- Fernandes, João B., et al. ; Silva, Taynara L.; Silva, M. Fátima das G.F. da; Consolaro, Helder N.; Sousa, Lorena R.F. de; Vieira, Paulo C.; Show all 6 Authors
- Source:
- Revista Brasileira de Farmacognosia 2019 v.29 no.4 pp. 491-494
- ISSN:
- 0102-695X
- Subject:
- Bowdichia; beta-sitosterol; cathepsin V; ethyl acetate; fractionation; hexane; lupeol; nuclear magnetic resonance spectroscopy; p-coumaric acid; stems; stigmasterol
- Abstract:
- ... Bioassay-guided fractionation of Bowdichia virgilioides Kunth, Fabaceae, extracts has led to the isolation of cathepsin V inhibitors. The investigation of the hexane and ethyl acetate extracts allowed the characterization of eleven compounds: lupeol, lupenone, β-sitosterol and stigmasterol in mixture, trans p-coumaric acid ester derivative, syringaresinol, bowdenol, 8-methoxycoumestrol, 3,4-hydrox ...
- DOI:
- 10.1016/j.bjp.2019.04.004
- https://dx.doi.org/10.1016/j.bjp.2019.04.004
- Author:
- Fernandes, João B., et al. ; dos Santos, Márcio G.; Moreno, Felipe S.; de Oliveira, Akila L.; Oliveira, Isadora C. F.; Tribuiani, Natália; Cogo, José C.; Scriboni, Andreia B.; Cogo-Müller, Karina; San Feliciano, Arturo; Jose Bonomini, Tiago; Oshima-Franco, Yoko; Show all 12 Authors
- Source:
- Natural product research 2019 v.33 no.16 pp. 2389-2393
- ISSN:
- 1478-6427
- Subject:
- Bothrops; Escherichia coli; Galactia; Pseudomonas aeruginosa; Staphylococcus aureus; aerial parts; antimicrobial properties; chromatography; leaves; light microscopy; muscles; neurotoxicity; neutralization; rutin; snake bites; spectroscopy; venoms; Brazil
- Abstract:
- ... Galactia glaucescens leaves are popularly used against snakebites in Brazil. The hydroethanolic extract from aerial parts of G. glaucescens (HEGg) was assayed against the neurotoxicity and myotoxicity induced by Bothrops jararacussu venom. A traditional myographic technique was applied for neurotoxicity and the resulting muscles were treated routinely by light microscopy analysis for myotoxicity. ...
- DOI:
- 10.1080/14786419.2018.1443086
- http://dx.doi.org/10.1080/14786419.2018.1443086
- Author:
- Fernandes, João B., et al. ; Nebo, Liliane; Varela, Rosa M.; Palma, Miguel; Show all 4 Authors
- Source:
- Antioxidants 2019 v.8 no.10
- ISSN:
- 2076-3921
- Subject:
- Ricinus communis; alkaloids; antioxidant activity; ethyl acetate; leaves; methanol; microwave treatment; solvents; temperature
- Abstract:
- ... The alkaloid ricinine (3-cyano-4-methoxy-N-methyl-2-pyridone) is found in different parts of the Ricinus communis plant and is known to possess several bioactive properties, including strong antioxidant activity. In this study, a new microwave-assisted extraction (MAE) method was developed for the recovery of ricinine from R. communis leaves. The extraction variables studied were extraction temper ...
- DOI:
- 10.3390/antiox8100438
- PubMed:
- 31581463
- PubMed Central:
- PMC6826910
- http://dx.doi.org/10.3390/antiox8100438
- Author:
- Fernandes, Joao B., et al. ; Gimenes, Leila; Luna-Dulcey, Liany; Batista, Joao M.; dos Santos, Fernando M.; Popolin, Cecília P.; Cominetti, Marcia R.; Staerk, Dan; Show all 8 Authors
- Source:
- Journal of natural products 2020 v.83 no.6 pp. 1859-1875
- ISSN:
- 1520-6025
- Subject:
- Picramnia; biochemical pathways; breast neoplasms; circular dichroism spectroscopy; cytotoxicity; ethanol; high performance liquid chromatography; leaves; lung neoplasms; mass spectrometry; methylene chloride; neoplasm cells; nuclear magnetic resonance spectroscopy; spectral analysis
- Abstract:
- ... In this study, HPLC-PDA-HRMS-SPE-NMR data were used for initial analysis of the CH₂Cl₂ fraction of an EtOH extract of the leaves of Picramnia glazioviana. The HRMS, UV, and NMR data obtained from the HPLC-PDA-HRMS-SPE-NMR analysis were used to direct semipreparative HPLC isolation toward nortriterpenoids, which resulted in the isolation of 18 new and highly oxygenated nortriterpenoids (1–3, 5–10, ...
- DOI:
- 10.1021/acs.jnatprod.0c00045
- http://dx.doi.org/10.1021/acs.jnatprod.0c00045
- Author:
- Fernandes, João B., et al. ; Ribeiro, Leandro P.; Domingues, Vanessa C.; Gonçalves, Gabriel L.P.; Glória, Eduardo M.; Vendramim, José D.; Show all 6 Authors
- Source:
- Food bioscience 2020 v.36 pp. 100653
- ISSN:
- 2212-4292
- Subject:
- Aspergillus flavus; Duguetia; Sitophilus zeamais; Zabrotes subfasciatus; aflatoxin B1; bioassays; chemical composition; chromatography; eggs; essential oils; fumigation; fungi; grains; hydrodistillation; imagos; insects; leaves; lethal concentration 50; median effective concentration; mortality; progeny; spectral analysis; stored grain; weight loss
- Abstract:
- ... To search for new compounds with promising grain-protective properties, this study evaluated the chemical composition and insecticidal, antifungal and antiaflatoxigenic activities of essential oil (EO) from the hydrodistillation of Duguetia lanceolata (Annonaceae) leaves on fungi and insects that spoil stored commodities. By combining the chromatographic and spectroscopic analyses, 5 compounds wer ...
- DOI:
- 10.1016/j.fbio.2020.100653
- https://dx.doi.org/10.1016/j.fbio.2020.100653
- Author:
- Fernandes, João B. K., et al. ; Rodrigues, Andressa T.; Mansano, Cleber F. M.; Khan, Kifayat U.; Nascimento, Thiago M. T.; Boaratti, André Z.; Sakomura, Nilva K.; Show all 7 Authors
- Source:
- Aquaculture research 2020 v.51 no.11 pp. 4724-4735
- ISSN:
- 1355-557X
- Subject:
- Oreochromis niloticus; arginine; developmental stages; essential amino acids; experimental diets; finishing; fish; histidine; ingredients; isoleucine; leucine; lysine; methionine; nitrogen retention; nutrient requirements; phenylalanine; tanks; threonine; tryptophan; valine
- Abstract:
- ... This study aimed to estimate the ideal profile of essential amino acids (EAAs) for Nile tilapia (Oreochromis niloticus) in the finishing growth phase. A total of 264 fish (initial average weight of 625 g) were distributed among randomly arranged 33 fibre tanks of 1000‐L water capacity each, connected to a water recirculation system. The 60‐day experiment consisted of 11 treatments with three repli ...
- DOI:
- 10.1111/are.14819
- http://dx.doi.org/10.1111/are.14819