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- Author:
- Wu, Ying-Li, et al. ; Zhao, Yong; Pu, Jian-Xin; Huang, Sheng-Xiong; Ding, Li-Sheng; Li, Li-Mei; Li, Xian; Yang, Li-Bin; Xiao, Wei-Lie; Chen, Guo-Qiang; Sun, Han-Dong; Show all 11 Authors
- Source:
- Planta medica 2012 v.78 no.1 pp. 52-58
- ISSN:
- 0032-0943
- Subject:
- aerial parts; cytotoxicity; diterpenoids; nuclear magnetic resonance spectroscopy
- Abstract:
- ... Eight new 19-oxygenated ent-kaurane diterpenoids (1-8) were isolated from the aerial parts of Isodon pharicus. Their structures were determined by means of extensive spectroscopic techniques including interpretation of 1D and 2D NMR spectra. Selected compounds were evaluated for their cytotoxicity against NB4, A549, PC-3, MCF-7, and SH-SY5Y cell lines. ...
- DOI:
- 10.1055/s-0031-1280218
- PubMed:
- 21964815
- https://doi.org/10.1055/s-0031-1280218
- Author:
- Wu, Ying-Li, et al. ; Gao, Xue-Mei; Luo, Xiao; Pu, Jian-Xin; Zhao, Yong; Yang, Li Bin; He, Fei; Li, Xiao Nian; Xiao, Wei-Lie; Chen, Guo-Qiang; Sun, Han-Dong; Show all 11 Authors
- Source:
- Planta medica 2011 v.77 no.2 pp. 169-174
- ISSN:
- 0032-0943
- Subject:
- cytotoxicity; diterpenoids; humans; leaves; spectroscopy
- Abstract:
- ... A phytochemical study of Isodon rubescens leaves led to the isolation of five new diterpenoids, isorubesins A-E (1-5), and fifteen known diterpenoids. The structures of these new compounds were elucidated by spectroscopic evidence. Most of the diterpenoids were tested for cytotoxicity against NB4, A549, SHSY5Y, PC3, and MCF7 human tumor cells. Some of them showed potent inhibitory activity. Compou ...
- DOI:
- 10.1055/s-0030-1250165
- PubMed:
- 20669088
- https://doi.org/10.1055/s-0030-1250165
- Author:
- Wu, Ying-Li, et al. ; He, Fei; Xiao, Wei-Lie; Pu, Jian-Xin; Zhang, Hai-Bo; Li, Xiao-Nian; Zhao, Yong; Yang, Li-Bin; Chen, Guo-Qiang; Sun, Han-Dong; Show all 10 Authors
- Source:
- Phytochemistry 2009 v.70 no.11-12 pp. 1462-1466
- ISSN:
- 0031-9422
- Subject:
- humans; phytochemicals; cytotoxicity; medicinal plants; diterpenoids; Isodon (Lamiaceae); spectral analysis; cell proliferation; chemical structure; stereochemistry; anticarcinogenic activity; China
- Abstract:
- ... Five (1-5) ent-kaurane diterpenoids and 17 other known ones, were isolated from the leaves and stems of Isodon sinuolata. Their structures were determined on the basis of spectroscopic methods including 1D and 2D NMR spectroscopic analysis. All compounds were evaluated for cytotoxicity against a small panel of cell lines. Some compounds exhibited significant cytotoxicity. ...
- DOI:
- 10.1016/j.phytochem.2009.07.037
- PubMed:
- 19712947
- https://doi.org/10.1016/j.phytochem.2009.07.037
- Author:
- Wu Ying-Li, et al. ; Liu Bin; Zheng Ying; Wang Tong-Dan; Xu Han-Zhang; Xia Li; Zhang Jian; Chen Guo-Qiang; Wang Li-Shun; Show all 9 Authors
- Source:
- Journal of Proteome Research 2012 v.11 no.3 pp. 1773-1781
- ISSN:
- 1535-3907
- Subject:
- F-box proteins; cell lines; databases; glycoproteins; liquid chromatography; mass spectrometry; mutants; proteomics; ubiquitin-protein ligase; ubiquitination
- Abstract:
- ... FBOX6 ubiquitin ligase complex is involved in the endoplasmic reticulum-associated degradation pathway by mediating the ubiquitination of glycoproteins. FBXO6 interacts with the chitobiose in unfolded N-glycoprotein, pointing glycoproteins toward E2 for ubiquitination. Although the glycoprotein-recognizing mechanism of FBXO6 is well documented, its bona fide interacting glycoproteins are largely u ...
- DOI:
- 10.1021/pr2010204
- https://doi.org/10.1021/pr2010204
- Author:
- Wu, Ying-Li, et al. ; Zhao, Yong; Pu, Jian-Xin; Huang, Sheng-Xiong; Ding, Li-Sheng; Li, Xian; Yang, Li-Bin; Xiao, Wei-Lie; Chen, Guo-Qiang; Sun, Han-Dong; Show all 10 Authors
- Source:
- Journal of natural products 2009 v.72 no.6 pp. 988-993
- ISSN:
- 0163-3864
- Subject:
- nuclear magnetic resonance spectroscopy; cytotoxicity; aerial parts; diterpenoids; Isodon (Lamiaceae); cell lines; chemical structure
- DOI:
- 10.1021/np9000366
- PubMed:
- 19425589
- https://doi.org/10.1021/np9000366
- Author:
- Wu, Ying-Li, et al. ; Zhao, Yong; Pu, Jian-Xin; Huang, Sheng-Xiong; Yang, Li-Bin; Xiao, Wei-Lie; Han, Quan-Bin; Chen, Guo-Qiang; Sun, Han-Dong; Show all 9 Authors
- Source:
- Journal of natural products 2009 v.72 no.1 pp. 125-129
- ISSN:
- 0163-3864
- Subject:
- human diseases; phytochemicals; cytotoxicity; diterpenoids; Isodon (Lamiaceae); spectral analysis; chemical structure; stereochemistry; anticarcinogenic activity; China
- DOI:
- 10.1021/np800484j
- PubMed:
- 19072209
- https://doi.org/10.1021/np800484j