Jump to Main Content
- Abernathy, Morgan E., et al. Show all 4 Authors
- Journal of the American Chemical Society 2016 v.138 no.24 pp. 7472-7475
- acids; ambient temperature; buffers; chemical bonding; histidine; polypeptides; proteins
- ... Chemical modification of proteins and peptides represents a challenge of reaction design as well as an important biological tool. In contrast to side-chain modification, synthetic methods to alter backbone structure are extremely limited. In this communication, copper-mediated backbone N-alkenylation or N-arylation of peptides and proteins by direct modification of natural sequences is described. ...