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1. Synergistic activity of bile salts and their derivatives in combination with conventional antimicrobial agents against Acinetobacter baumannii

Author:
Aleksić Sabo, Verica; Škorić, Dušan; Jovanović-Šanta, Suzana; Nikolić, Isidora; János, Csanádi; Knežević, Petar
Source:
Journal of ethnopharmacology 2021 v.264 pp. 113266
ISSN:
0378-8741
Subject:
Acinetobacter baumannii,   etc   ; antibacterial properties; antibiotic resistance; antioxidants; bile; bile salts; ciprofloxacin; deoxycholic acid; etiological agents; gentamicin; micelles; multiple drug resistance; nuclear magnetic resonance spectroscopy; sodium; synergism; tissue repair; traditional medicine;     Show all 17 Subjects
Abstract:
... Bile traditionally was used in wound healing, having erodent, antioxidant and antimicrobial potential. Acinetobacter baumannii is a frequent etiological agent of wound infections, exhibiting high level of resistance to conventional antibiotics.To determine the effect of selected bile acid sodium salts and their 3-dehydro (i.e. 3-oxo) derivatives, as well as their combinations with commercial antib ...
DOI:
10.1016/j.jep.2020.113266

2. Efficient Strategy for α-Selective Glycosidation of d-Glucosamine and Its Application to the Synthesis of a Bacterial Capsular Polysaccharide Repeating Unit Containing Multiple α-Linked GlcNAc Residues

Author:
Zhang, Yanxin; Zhang, Han; Zhao, Ying; Guo, Zhongwu; Gao, Jian
Source:
Organic letters 2020 v.22 no.4 pp. 1520-1524
ISSN:
1523-7052
Subject:
Acinetobacter baumannii,   etc   ; glucosamine; glycosylation; moieties; polysaccharides; synthesis;     Show all 6 Subjects
Abstract:
... An efficient α-selective glycosylation method was developed for the synthesis of 2-deoxy-2-amino-d-glucosides based on synergetic α-directing effects of the TolSCl/AgOTf promotion system and the functional groups at the corresponding azido donor 6-O-position to exert steric β-shielding effect or remote participation in the glycosylation reaction. Its practicability was verified with a wide range o ...
DOI:
10.1021/acs.orglett.0c00101

3. Regulatory networks important for survival of Acinetobacter baumannii within the host

Author:
Allen, Jessie L; Tomlinson, Brooke R; Casella, Leila G; Shaw, Lindsey N
Source:
Current opinion in microbiology 2020 v.55 pp. 74-80
ISSN:
1369-5274
Subject:
Acinetobacter baumannii,   etc   ; antibiotics; humans; patients; resistance genes; transcription factors; virulence;     Show all 7 Subjects
Abstract:
... Acinetobacter baumannii is known for its intrinsic resistance to conventional antibiotic treatment and hypervirulence during infection. This coupled with its extraordinary capacity to survive in myriad harsh environments has led to increasing rates of infection in clinical settings. Numerous studies have characterized the virulence factors and resistance genes in A. baumannii responsible for the d ...
DOI:
10.1016/j.mib.2020.03.001

4. AbaR is a LuxR type regulator essential for motility and the formation of biofilm and pellicle in Acinetobacter baumannii

Author:
Oh, Man Hwan; Han, Kyudong
Source:
Genes & genomics 2020 v.42 no.11 pp. 1339-1346
ISSN:
1976-9571
Subject:
Acinetobacter baumannii,   etc   ; biofilm; cross infection; enzymes; mutants; mutation; quorum sensing; secondary infection;     Show all 8 Subjects
Abstract:
... BACKGROUND: Acinetobacter baumannii is a major opportunistic pathogen causing nosocomial infections. Acinetobacter baumannii possesses a quorum sensing system consisting of abaI, encoding an autoinducer synthase, and abaR, encoding a putative LuxR type regulator. AbaI is required for motility and biofilm formation in A. baumannii. However, the functions of AbaR on the expression of abaI, motility, ...
DOI:
10.1007/s13258-020-01005-8

5. ICEs Are the Main Reservoirs of the Ciprofloxacin-Modifying crpP Gene in Pseudomonas aeruginosa

Author:
Botelho, João; Grosso, Filipa; Peixe, Luísa
Source:
Genes 2020 v.11 no.8
ISSN:
2073-4425
Subject:
Acinetobacter baumannii,   etc   ; Escherichia coli; Klebsiella pneumoniae; Pseudomonas aeruginosa; cell movement; chromosomes; genes; physiological transport; plasmids;     Show all 9 Subjects
Abstract:
... The ciprofloxacin-modifying crpP gene was recently identified in a plasmid isolated from a Pseudomonas aeruginosa clinical isolate. Homologues of this gene were also identified in Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii. We set out to explore the mobile elements involved in the acquisition and spread of this gene in publicly available and complete genomes of Pseudomonas ...
DOI:
10.3390/genes11080889

6. A mycophenolic acid derivative from the fungus Penicillium sp. SCSIO sof101

Author:
Song, Xiaoxian; Tu, Ruxia; Mei, Xiaoli; Wu, Silan; Lan, Bo; Zhang, Li; Luo, Xianqin; Liu, Jianyi; Luo, Minghe
Source:
Natural product research 2020 v.34 no.9 pp. 1206-1212
ISSN:
1478-6427
Subject:
Acinetobacter baumannii,   etc   ; Escherichia coli; Penicillium; bioactive properties; carbon; fungi; metabolites; nuclear magnetic resonance spectroscopy; stable isotopes;     Show all 9 Subjects
Abstract:
... Mycophenolic acid (MPA) is a group of metabolite derived from several species of Penicillium, which shows potent bioactivity. In this study, a new derivative of MPA compound named penicacid D (1), was isolated from the marine derived fungus Penicillium sp. SCSIO sof101, along with seven known compounds (2-8). Their structures were elucidated based on the HR-ESI-MS and NMR data. Moreover, the ¹H an ...
DOI:
10.1080/14786419.2018.1553881

7. Localization of Double Bonds in Bacterial Glycerophospholipids Using 193 nm Ultraviolet Photodissociation in the Negative Mode

Author:
Klein, Dustin R.; Blevins, Molly S.; Macias, Luis A.; Douglass, Martin V.; Trent, M. Stephen; Brodbelt, Jennifer S.
Source:
Analytical chemistry 2020 v.92 no.8 pp. 5986-5993
ISSN:
1520-6882
Subject:
Acinetobacter baumannii,   etc   ; Escherichia coli; anions; carbon; cations; chemical bonding; lipids; liquid chromatography; mass spectrometry; photolysis;     Show all 10 Subjects
Abstract:
... The need for detailed structural characterization of glycerophospholipids (GPLs) for many types of biologically motivated applications has led to the development of novel mass spectrometry-based methodologies that utilize alternative ion activation methods. Ultraviolet photodissociation (UVPD) has shown great utility for localizing sites of unsaturation within acyl chains and to date has predomina ...
DOI:
10.1021/acs.analchem.0c00221

8. Total Syntheses of Fimsbactin A and B and Their Stereoisomers to Probe the Stereoselectivity of the Fimsbactin Uptake Machinery in Acinetobacter baumannii

Author:
Kim, Soojeung; Lee, Haeun; Song, Woon Young; Kim, Hak Joong
Source:
Organic letters 2020 v.22 no.7 pp. 2806-2810
ISSN:
1523-7052
Subject:
Acinetobacter baumannii,   etc   ; animal pathogens; bacteria; chemical reactions; iron; organic compounds; siderophores; stereoisomers; stereoselective synthesis; stereoselectivity;     Show all 10 Subjects
Abstract:
... The stereoselective synthesis of fimsbactin A, a siderophore of the human pathogen Acinetobacter baumannii, was established. Based on this synthetic route, various fimsbactin stereoisomeric analogues were generated and tested for their iron delivery activity for A. baumannii. This investigation revealed that the fimsbactin uptake machinery in this bacterium was indeed highly stereoselective in sub ...
DOI:
10.1021/acs.orglett.0c00790

9. Bio-assay of Acintobacter baumannii using DNA conjugated with gold nano-star: A new platform for microorganism analysis

Author:
Bahavarnia, Farnaz; Mobed, Ahmad; Hasanzadeh, Mohammad; Saadati, Arezoo; Hassanpour, Soodabeh; Mokhtarzadeh, Ahad
Source:
Enzyme and microbial technology 2020 v.133 pp. 109466
ISSN:
0141-0229
Subject:
Acinetobacter baumannii,   etc   ; biosensors; chemical bonding; complementary DNA; gold; microbial detection; nanogold; nucleic acid hybridization;     Show all 8 Subjects
Abstract:
... Acinetobacter baumannii is a non-motile, gram-negative member of the gamma proteobacteria. A specific and sensitive approach was established for the detection of Acintobacter baumannii via DNA based bio-assay. In this study, gold nano-star was synthesized and used for bio-conjugation with pDNA toward the detection of target sequences. Synthesized probe (5ʹ TTG TGA ACT ATT TAC GTC AGC ATG C3ʹ) of A ...
DOI:
10.1016/j.enzmictec.2019.109466

10. Temporal evolution of Acinetobacter baumannii ST107 clone: conversion of blaOXA-143 into blaOXA-231 coupled with mobilization of ISAba1 upstream occAB1

Author:
Rodrigues-Costa, Fernanda; Cayô, Rodrigo; Matos, Adriana Pereira; Girardello, Raquel; Martins, Willames M.B.S.; Carrara-Marroni, Floristher Elaine; Gales, Ana Cristina
Source:
Research in microbiology 2019 v.170 no.1 pp. 53-59
ISSN:
0923-2508
Subject:
Acinetobacter baumannii,   etc   ; carbapenems; mutation; transcription (genetics);     Show all 4 Subjects
Abstract:
... Nine carbapenem-resistant Acinetobacter baumannii isolates carrying blaOXA-231 and an ISAba1 upstream occAB1 were evaluated. They were clonally related and belonged to ST107. An OXA-143-producing A. baumannii ST107 strain (Ac-148) that did not possess ISAba1 upstream occAB1 was included in the analysis. Reduction in the expression of occAB1 and a 4-fold increase of carbapenem MICs were observed fo ...
DOI:
10.1016/j.resmic.2018.07.001

11. Antibiotic Activity of Wickerhamomyces anomalus Mycocins on Multidrug-Resistant Acinetobacter baumannii

Author:
Junges, Daniele S. B.; Delabeneta, Mateus F.; Rosseto, Lana Rubia B.; Nascimento, Bruna L.; Paris, Ana Paula; Persel, Cristiane; Loth, Eduardo A.; Simão, Rita C. G.; Menolli, Rafael A.; Paula, Claudete R.; Gandra, Rinaldo F.
Source:
Microbial ecology 2020 v.80 no.2 pp. 278-285
ISSN:
0095-3628
Subject:
Acinetobacter baumannii,   etc   ; Artemia salina; Wickerhamomyces anomalus; agar; antibacterial properties; cytotoxicity; erythrocytes; minimum inhibitory concentration; multiple drug resistance;     Show all 9 Subjects
Abstract:
... To evaluate the susceptibility of multidrug-resistant Acinetobacter baumannii to mycocins produced by Wickerhamomyces anomalus and to verify the cytotoxicity of these compounds. Three culture supernatants of W. anomalus (WA40, WA45, and WA92), containing mycocins (WA40M1, WA45M2, and WA92M3), were tested on A. baumannii using broth microdilution methods, solid medium tests, and cytotoxicity tests ...
DOI:
10.1007/s00248-020-01495-9

12. Discovery of multidrug efflux pump inhibitors with a novel chemical scaffold

Author:
Green, Adam T.; Moniruzzaman, Mohammad; Cooper, Connor J.; Walker, John K.; Smith, Jeremy C.; Parks, Jerry M.; Zgurskaya, Helen I.
Source:
Biochimica et biophysica acta 2020 v.1864 no.6 pp. 129546
ISSN:
0304-4165
Subject:
Acinetobacter baumannii,   etc   ; Escherichia coli; Gram-negative bacteria; Klebsiella pneumoniae; antibiotic resistance; antimicrobial properties; erythromycin; membrane fusion; novobiocin; pathogens; permeability; transporters;     Show all 12 Subjects
Abstract:
... Multidrug efflux is a major contributor to antibiotic resistance in Gram-negative bacterial pathogens. Inhibition of multidrug efflux pumps is a promising approach for reviving the efficacy of existing antibiotics. Previously, inhibitors targeting both the efflux transporter AcrB and the membrane fusion protein AcrA in the Escherichia coli AcrAB-TolC efflux pump were identified. Here we use existi ...
DOI:
10.1016/j.bbagen.2020.129546
PubMed:
32032658
PubMed Central:
PMC7153915

13. Comparison of the recommended colistin susceptibility testing methods with colistin gradient strips and semi-automated method for antimicrobial-resistant non-fermenting rods

Author:
Depka, Dagmara; Mikucka, Agnieszka; Bogiel, Tomasz; Gospodarek-Komkowska, Eugenia
Source:
Journal of microbiological methods 2020 v.172 pp. 105905
ISSN:
0167-7012
Subject:
Acinetobacter baumannii,   etc   ; Pseudomonas aeruginosa; antibiotic resistance; automation; colistin; data analysis; minimum inhibitory concentration; multiple drug resistance; Italy;     Show all 9 Subjects
Abstract:
... An increased frequency of multidrug-resistant non-fermenting rods isolation has resulted in the excessive use of colistin – often the last chance antimicrobial. However, determination of colistin susceptibility is difficult, mainly because of its structure and limited diffusion properties. This study was performed to compare colistin susceptibility testing among Pseudomonas aeruginosa (n = 49) and ...
DOI:
10.1016/j.mimet.2020.105905

14. Distribution of carbapenem resistant Acinetobacter baumannii with blaADC-30 and induction of ADC-30 in response to beta-lactam antibiotics

Author:
Ingti, Birson; Upadhyay, Supriya; Hazarika, Monalisha; Khyriem, Annie Bakorlin; Paul, Deepjyoti; Bhattacharya, Prithwis; Joshi, S.R.; Bora, Debajyoti; Dhar, Debadatta; Bhattacharjee, Amitabha
Source:
Research in microbiology 2020 v.171 no.3-4 pp. 128-133
ISSN:
0923-2508
Subject:
Acinetobacter baumannii,   etc   ; antibiotic resistance; aztreonam; beta-lactamase; cefoxitin; ceftazidime; ceftriaxone; genes; hospitals; imipenem; meropenem; messenger RNA; patients;     Show all 13 Subjects
Abstract:
... A wide range of intrinsic Acinetobacter-derived cephalosporinases (ADC) along with other carbapenemases has now been detected in Acinetobacter baumannii leaving clinicians with few treatment options. The present study reports the spread of ADC-30 co-producing KPC-2 along with other β-lactamases among carbapenem resistant A. baumannii strains obtained from ICU patients in two Indian hospitals. Prim ...
DOI:
10.1016/j.resmic.2020.01.002

15. In vitro interactions of ambroxol hydrochloride or amlodipine in combination with antibacterial agents against carbapenem‐resistant Acinetobacter baumannii

Author:
Wang, Y.; Li, X.; Wang, D.; Sun, S.; Lu, C.
Source:
Letters in applied microbiology 2020 v.70 no.3 pp. 189-195
ISSN:
0266-8254
Subject:
Acinetobacter baumannii,   etc   ; antibiotic resistance; bacterial infections; drug interactions; drugs; meropenem; models; polymyxin B; sodium; synergism; tigecycline; toxicity;     Show all 12 Subjects
Abstract:
... The aim of this study was to investigate the in vitro interactions of ambroxol hydrochloride (ABH) or amlodipine (AML) with commonly used antibacterial agents, including meropenem, imipenem‐cilastatin sodium, biapenem, cefoperazone‐sulbactam, polymyxin B, and tigecycline, against six carbapenem‐resistant Acinetobacter baumannii (CRAB) clinical isolates. Drug interactions were interpreted using two ...
DOI:
10.1111/lam.13259

16. A Deep Learning Approach to Antibiotic Discovery

Author:
Stokes, Jonathan M.; Yang, Kevin; Swanson, Kyle; Jin, Wengong; Cubillos-Ruiz, Andres; Donghia, Nina M.; MacNair, Craig R.; French, Shawn; Carfrae, Lindsey A.; Bloom-Ackermann, Zohar; Tran, Victoria M.; Chiappino-Pepe, Anush; Badran, Ahmed H.; Andrews, Ian W.; Chory, Emma J.; Church, George M.; Brown, Eric D.; Jaakkola, Tommi S.; Barzilay, Regina; Collins, James J.
Source:
Cell 2020 v.180 no.4 pp. 688-702.e13
ISSN:
0092-8674
Subject:
Acinetobacter baumannii,   etc   ; Clostridium difficile; Enterobacteriaceae; Mycobacterium tuberculosis; animal models; antibacterial properties; antibiotic resistance; antibiotics; bacteria; databases; drugs; pathogens; phylogeny; prediction;     Show all 14 Subjects
Abstract:
... Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting molecules with antibacterial activity. We performed predictions on multiple chemical libraries and discovered a molecule from the Drug Repurposing Hub—halicin—that is structurally divergent from conventio ...
DOI:
10.1016/j.cell.2020.01.021

17. Pharmacokinetic and pharmacodynamic profiling of four antimicrobials against Acinetobacter baumannii infection

Author:
Zhu, Wan; Chu, Yunzhuo; Zhang, Jingping; Xian, Wei; Xu, Xueying; Liu, Hongbo
Source:
Microbial pathogenesis 2020 v.138 pp. 103809
ISSN:
0882-4010
Subject:
Acinetobacter baumannii,   etc   ; cefoperazone; colistin; drugs; imipenem; induced resistance; monitoring; patients; pharmacodynamics; pharmacokinetics; probability; sulbactam; sulfonates; therapeutics; tigecycline; China;     Show all 16 Subjects
Abstract:
... The aim of this study was to evaluate common antimicrobial regimens used in eradicating Acinetobacter baumannii in Shenyang, China.Monte Carlo simulation was conducted to estimate the probability target attainment (PTA) and cumulative fraction of response (CFR) for imipenem, cefoperazone/sulbactam (2:1), tigecycline and colistin methanesulfonate.For the results of PTAs, imipenem following administ ...
DOI:
10.1016/j.micpath.2019.103809

18. Evolutionary dynamics of carbapenem-resistant Acinetobacter baumannii circulating in Chilean hospitals

Author:
Opazo-Capurro, Andrés; San Martín, Iván; Quezada-Aguiluz, Mario; Morales-León, Felipe; Domínguez-Yévenes, Mariana; Lima, Celia A.; Esposito, Fernanda; Cerdeira, Louise; Bello-Toledo, Helia; Lincopan, Nilton; González-Rocha, Gerardo
Source:
Infection, genetics, and evolution 2019 v.73 pp. 93-97
ISSN:
1567-1348
Subject:
Acinetobacter baumannii,   etc   ; beta-lactamase; cross infection; epidemiology; hospitals; Chile;     Show all 6 Subjects
Abstract:
... We analyze the evolutionary dynamics of ninety carbapenem-resistant Acinetobacter baumannii (CRAB) isolates collected between 1990 and 2015 in Chile. CRAB were identified at first in an isolate collected in 2005, which harbored the ISAba1-blaOXA-69 arrangement. Later, OXA-58- and OXA-23-producing A. baumannii strains emerged in 2007 and 2009, respectively. This phenomenon was associated with varia ...
DOI:
10.1016/j.meegid.2019.04.022

19. Polyclonal predominance of concurrently producing OXA-23 and OXA-58 carbapenem-resistant Acinetobacter baumannii strains in a pediatric intensive care unit

Author:
Karampatakis, Theodoros; Tsergouli, Katerina; Politi, Lida; Diamantopoulou, Georgia; Iosifidis, Elias; Antachopoulos, Charalampos; Karyoti, Aggeliki; Sdougka, Maria; Tsakris, Athanassios; Roilides, Emmanuel
Source:
Molecular biology reports 2019 v.46 no.3 pp. 3497-3500
ISSN:
0301-4851
Subject:
Acinetobacter baumannii,   etc   ; antibiotic resistance; beta-lactamase; carbapenems; children; hospitals;     Show all 6 Subjects
Abstract:
... We report a predominance (64.7%) of polyclonal carbapenem-resistant Acinetobacter baumannii (CRAB) strains concurrently producing OXA-23 and OXA-58 carbapenemases in a pediatric intensive care unit in an endemic area. This is the first report of emergence of such double-OXA CRAB strains in a single unit worldwide. ...
DOI:
10.1007/s11033-019-04744-4

20. Molecular investigation and genetic diversity of Pediculus and Pthirus lice in France

Author:
Amanzougaghene, Nadia; Mediannikov, Oleg; Ly, Tran Duc Anh; Gautret, Philippe; Davoust, Bernard; Fenollar, Florence; Izri, Arezki
Source:
Parasites & vectors 2020 v.13 no.1 pp. 177
ISSN:
1756-3305
Subject:
Acinetobacter baumannii,   etc   ; Bartonella quintana; Coxiella burnetii; DNA; Pediculus humanus capitis; Pthirus pubis; common names; disease vectors; genetic variation; humans; lice; parasitism; pathogens; France;     Show all 14 Subjects
Abstract:
... BACKGROUND: Humans are parasitized by three types of lice: body, head and pubic lice. As their common names imply, each type colonizes a specific region of the body. The body louse is the only recognized disease vector. However, an increasing awareness of head lice as a vector has emerged recently whereas the status of pubic lice as a vector is not known since it has received little attention. MET ...
DOI:
10.1186/s13071-020-04036-y
PubMed:
32264930
PubMed Central:
PMC7140345