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- Akhavanfard, Sara, et al. Show all 14 Authors
- Science 2011 v.331 no.6017 pp. 593-596
- adenocarcinoma; animal ovaries; biomarkers; colon; epithelium; gene overexpression; gene silencing; genes; heterochromatin; humans; kidneys; mice; microsatellite repeats; non-coding RNA; plant ovary; retrotransposons; satellites; transcription (genetics)
- ... Satellite repeats in heterochromatin are transcribed into noncoding RNAs that have been linked to gene silencing and maintenance of chromosomal integrity. Using digital gene expression analysis, we showed that these transcripts are greatly overexpressed in mouse and human epithelial cancers. In 8 of 10 mouse pancreatic ductal adenocarcinomas (PDACs), pericentromeric satellites accounted for a mean ...
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