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You searched for: Author "Aleksei Krasnov" Remove constraint Author: "Aleksei Krasnov"
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1. Exposure to retene, fluoranthene, and their binary mixture causes distinct transcriptomic and apical outcomes in rainbow trout (Oncorhynchus mykiss) yolk sac alevins

Author:
Aleksei Krasnov,   et al.   ; Andreas N.M. Eriksson; Cyril Rigaud; Emma Wincent; Eeva-Riikka Vehniäinen;     Show all 5 Authors
Source:
Aquatic toxicology 2022 v.244 pp. 106083
ISSN:
0166-445X
Subject:
G-proteins; Oncorhynchus mykiss; agonists; alevins; aryl hydrocarbon receptors; cardiotoxicity; cell membranes; heart; metabolism; microarray technology; oxidative stress; pollution; potassium; toxicity; toxicology; transcriptomics; xenobiotics; yolk sac
Abstract:
... Polycyclic aromatic hydrocarbons (PAHs) are widely spread environmental contaminants which affect developing organisms. It is known that improper activation of the aryl hydrocarbon receptor (AhR) by some PAHs contributes to toxicity, while other PAHs can disrupt cellular membrane function. The exact downstream mechanisms of AhR activation remain unresolved, especially with regard to cardiotoxicity ...
DOI:
10.1016/j.aquatox.2022.106083

2. Responses to Mineral Supplementation and Salmon Lice (Lepeophtheirus salmonis) Infestation in Skin Layers of Atlantic Salmon (Salmo salar L.)

Author:
Aleksei Krasnov,   et al.   ; Lene Sveen; Gerrit Timmerhaus; Andrè Sture Bogevik;     Show all 4 Authors
Source:
Genes 2021 v.12 no.4 pp. -
ISSN:
2073-4425
Subject:
Lepeophtheirus salmonis; Salmo salar; aquaculture; data collection; dermis; diet; genes; salmon; transcription (genetics); transcriptome; wheat
Abstract:
... The crustacean ectoparasite salmon louse (Lepeophtheirus salmonis), which severely affects Atlantic salmon health and welfare is one of the main problems of commercial aquaculture. In the present study, fish were fed a diet supplemented with extra minerals through the inclusion of a commercial additive (Biofeed Forte Salmon), substituting wheat in the control diet, before experimental infestation ...
DOI:
10.3390/genes12040602

3. Transcriptome and functional responses to absence of astaxanthin in Atlantic salmon fed low marine diets

Author:
Aleksei Krasnov,   et al.   ; Trine Ytrestøyl; Sergey Afanasyev; Bente Ruyter; Bjarne Hatlen; Tone-Kari Østbye;     Show all 6 Authors
Source:
Comparative biochemistry and physiology 2021 v.39 pp. 100841
ISSN:
1744-117X
Subject:
DNA microarrays; Salmo salar; astaxanthin; biosynthesis; diet; fish meal; fish oils; gene expression; growth performance; immunity; inflammation; intestines; lipid content; lipid metabolism; liver; malabsorption; muscles; proximate composition; risk; salmon; seawater; skeletal muscle; transcriptome
Abstract:
... High content of carotenoids in tissues of salmonid species suggests possible functional importance, which has so far remained unclear. The objective of this study was to investigate the effect of astaxanthin on performance and gene expression of sea water adapted Atlantic salmon (Salmo salar) fed diets with low content of marine ingredients (7.5% fishmeal and 5% fish oil). Salmon with start weight ...
DOI:
10.1016/j.cbd.2021.100841

4. A full factorial design to investigate interactions of variable essential amino acids, trace minerals and vitamins on Atlantic salmon smoltification and post transfer performance

Author:
Aleksei Krasnov,   et al.   ; Katerina Kousoulaki; Elisabeth Ytteborg; John Sweetman; Mona Elisabeth Pedersen; Vibeke Høst; Richard Murphy;     Show all 7 Authors
Source:
Aquaculture reports 2021 v.20 pp. 100704
ISSN:
2352-5134
Subject:
Salmo salar; aquaculture; astaxanthin; body weight; carotenes; digestibility; energy metabolism; erythropoiesis; essential amino acids; extracellular matrix; fish meal; genes; immunohistochemistry; immunomodulation; intestines; mortality; salmon; smoltification; transcription (genetics); transcriptomics; vitamin supplements
Abstract:
... To contribute in knowledge for the development of safe, efficient and sustainable functional salmon diets, we ran a feeding trial applying a 2³ full factorial design to investigate combined effects, on Atlantic salmon smoltification and post transfer performance, of variable supplementation levels of essential amino acid (Lys, Met, Thr and Arg), essential trace mineral (Zn, Fe and Se) and vitamins ...
DOI:
10.1016/j.aqrep.2021.100704

5. Multigene Expression Assay for Assessment of the Immune Status of Atlantic Salmon

Author:
Aleksei Krasnov,   et al.   ; Sergey Afanasyev; Stian Nylund; Alexander Rebl;     Show all 4 Authors
Source:
Genes 2020 v.11 no.11 pp. -
ISSN:
2073-4425
Subject:
Salmo salar; adaptive immunity; cathelicidins; discriminant analysis; gene expression; immune system; immunocompetence; inflammation; mortality; salmon; smolts; transcriptome; Norway
Abstract:
... We report the development of a multigene gene expression assay on the BioMark HD platform for the evaluation of immune competence (ImCom) in farmed Atlantic salmon. The first version of the assay included 92 genes selected on the basis of transcriptome analyses in 54 trials that challenged the immune system; annotations were taken into account to represent the key pathways of innate and adaptive i ...
DOI:
10.3390/genes11111236

6. In vivo and in vitro assessment of Atlantic salmon skin exposed to hydrogen peroxide

Author:
Aleksei Krasnov,   et al.   ; Christian Karlsen; André Sture Bogevik; Elisabeth Ytteborg;     Show all 4 Authors
Source:
Aquaculture 2021 v.540 pp. 736660
ISSN:
0044-8486
Subject:
Lepeophtheirus salmonis; Salmo salar; antiparasitic agents; cell cycle; cell differentiation; cortisol; fish; glucose; histology; hydrogen peroxide; industry; lactic acid; neutralization; pH; temperature; transcriptome
Abstract:
... The salmon louse (Lepeophtheirus salmonis) is a significant problem in Atlantic salmon aquaculture. The industry is forced to use harsh antiparasitic treatments, including hydrogen peroxide (H₂O₂) baths, to treat the fish. We have utilized in vivo, semi in vivo, and in vitro methods to study the effects of exposures to H₂O₂. Assessment of external welfare indicators and plasma levels of cortisol, ...
DOI:
10.1016/j.aquaculture.2021.736660

7. Effect of two constant light regimens on antibody profiles and immune gene expression in Atlantic salmon following vaccination and experimental challenge with salmonid alphavirus

Author:
Aleksei Krasnov,   et al.   ; Anne Flore Bakke; Alexander Rebl; Petter Frost; Sergey Afanasyev; Kristoffer Alnes Røyset; Tina Søfteland; Hege Lund; Preben Boysen;     Show all 9 Authors
Source:
Fish & shellfish immunology 2021 v.118 pp. 188-196
ISSN:
1050-4648
Subject:
Alphavirus; Salmo salar; antibodies; antibody formation; blood serum; freshwater; gene expression; heart; salmon; seawater; shellfish; smoltification; spleen; vaccination; vaccines; viruses
Abstract:
... Before seawater transfer, farmed Atlantic salmon are subjected to treatments that may affect the immune system and susceptibility to pathogens. E.g., exposure to constant light (CL) stimulates smoltification, which prepares salmon to life in sea water, but endocrine changes in this period are associated with suppression of immune genes. Salmon are vaccinated towards end of the freshwater period to ...
DOI:
10.1016/j.fsi.2021.07.002

8. Characterization of Differentially Expressed miRNAs and Their Predicted Target Transcripts during Smoltification and Adaptation to Seawater in Head Kidney of Atlantic Salmon

Author:
Aleksei Krasnov,   et al.   ; Alice Shwe; Tone-Kari Knutsdatter Østbye; Sigmund Ramberg; Rune Andreassen;     Show all 5 Authors
Source:
Genes 2020 v.11 no.9 pp. -
ISSN:
2073-4425
Subject:
Salmo salar; biosynthesis; cluster analysis; gene expression; gene expression regulation; gene ontology; genes; immune response; kidneys; messenger RNA; microRNA; microarray technology; saline water; seawater; sequence analysis; smoltification; stress management
Abstract:
... Smoltification and early seawater phase are critical developmental periods with physiological and biochemical changes in Atlantic salmon that facilitates survival in saltwater. MicroRNAs (miRNAs) are known to have important roles in development, but whether any miRNAs are involved in regulation of gene expression during smoltification and the adaption to seawater is largely unknown. Here, small RN ...
DOI:
10.3390/genes11091059

9. Skin and bone development in Atlantic salmon (Salmo salar) influenced by hatchery environment

Author:
Aleksei Krasnov,   et al.   ; Nicholas Robinson; Christian Karlsen; Elisabeth Ytteborg; Jascha Gerwins; Hanne Johnsen; Jelena Kolarevic;     Show all 7 Authors
Source:
Aquaculture 2021 v.544 pp. 737155
ISSN:
0044-8486
Subject:
Salmo salar; biosecurity; calcitonin; collagen; cytoskeleton; early development; eggs; gene expression; hatcheries; inner ear; keratin; metalloproteinases; mineralization; salmon; skeletal development; skeleton
Abstract:
... Recirculating aquaculture systems (RAS) are receiving greater attention because they have potential to reduce the use of water, enable better control of environmental conditions and give greater biosecurity. However, little is known about the effects of conditions in RAS on early development. Here we compare the survival, development and gene expression of Atlantic salmon grown in a RAS and flow t ...
DOI:
10.1016/j.aquaculture.2021.737155

10. Choline supplementation prevents diet induced gut mucosa lipid accumulation in post-smolt Atlantic salmon (Salmo salar L.)

Author:
Aleksei Krasnov,   et al.   ; Anne Kristine G. Hansen; Trond M. Kortner; Ingemar Björkhem; Michael Penn; Åshild Krogdahl;     Show all 6 Authors
Source:
BMC veterinary research 2020 v.16 no.1 pp. 32
ISSN:
1746-6148
Subject:
Salmo salar; animal growth; appearance (quality); cecum; cholesterol; choline; choline chloride; correlation; enterocytes; farmed fish; farmers; gene expression; ingredients; knowledge; lipid metabolism; lipoproteins; malabsorption; phosphatidylcholines; research; salmon; seawater; secretion; synthesis; triacylglycerols; veterinary medicine; weight
Abstract:
... BACKGROUND: Various intestinal morphological alterations have been reported in cultured fish fed diets with high contents of plant ingredients. Since 2000, salmon farmers have reported symptoms indicating an intestinal problem, which we suggest calling lipid malabsorption syndrome (LMS), characterized by pale and foamy appearance of the enterocytes of the pyloric caeca, the result of lipid accumul ...
DOI:
10.1186/s12917-020-2252-7

11. Characterisation of the teleostean κB-Ras family: The two members NKIRAS1 and NKIRAS2 from rainbow trout influence the activity of NF-κB in opposite ways

Author:
Aleksei Krasnov,   et al.   ; Fabio Sarais; Henrike Rebl; Marieke Verleih; Sven Ostermann; Bernd Köllner; Tom Goldammer; Alexander Rebl;     Show all 8 Authors
Source:
Fish & shellfish immunology 2020 v.106 pp. 1004-1013
ISSN:
1050-4648
Subject:
Oncorhynchus mykiss; cytoplasm; fish; mammals; sequence analysis; shellfish
Abstract:
... Two structurally similar NF-κB-inhibitor-interacting Ras-like proteins (NKIRAS) regulate the activity of the transcription factor NF-κB and thereby control several early immune mechanisms in mammals. We identified the orthologous sequences of NKIRAS1 and NKIRAS2 from the rainbow trout Oncorhynchus mykiss. The level of sequence identity was similarly high (≥68%) between the two and in comparison to ...
DOI:
10.1016/j.fsi.2020.08.052

12. Retene, pyrene and phenanthrene cause distinct molecular-level changes in the cardiac tissue of rainbow trout (Oncorhynchus mykiss) larvae, part 1 – Transcriptomics

Author:
Aleksei Krasnov,   et al.   ; Cyril Rigaud; Andreas Eriksson; Emma Wincent; Hannu Pakkanen; Heli Lehtivuori; Janne Ihalainen; Eeva-Riikka Vehniäinen;     Show all 8 Authors
Source:
Science of the total environment 2020 v.745 pp. 141031
ISSN:
0048-9697
Subject:
Oncorhynchus mykiss; Salmo salar; actin; calcium; cardiotoxicity; electron transport chain; environment; gene expression regulation; homeostasis; iron absorption; microarray technology; models; muscle contraction; myosin; oxygen; phenanthrenes; toxicity; transcriptome; transcriptomics
Abstract:
... Polycyclic aromatic hydrocarbons (PAHs) are contaminants of concern that impact every sphere of the environment. Despite several decades of research, their mechanisms of toxicity are still poorly understood. This study explores the mechanisms of cardiotoxicity of the three widespread model PAHs retene, pyrene and phenanthrene in the rainbow trout (Oncorhynchus mykiss) early life stages. Newly hatc ...
DOI:
10.1016/j.scitotenv.2020.141031

13. Sensitivity to Dietary Wheat Gluten in Atlantic Salmon Indicated by Gene Expression Changes in Liver and Intestine

Author:
Aleksei Krasnov,   et al.   ; Amritha Johny; Gerd Marit Berge; André S. Bogevik; Bente Ruyter; Christiane Kruse Fæste; Tone-Kari Knutsdatter Østbye;     Show all 7 Authors
Source:
Genes 2020 v.11 no.11 pp. -
ISSN:
2073-4425
Subject:
Salmo salar; amino acid composition; animal health; digestibility; energy density; feed conversion; feed intake; feed safety; fish feeds; fish meal; food safety; gene expression; human health; immunity; intestines; lipid content; lipid metabolism; lipoproteins; liver; malnutrition; protein sources; salmon; sterols; transcriptome; wheat gluten
Abstract:
... Feed safety is a necessity for animal health and welfare as well as prerequisite for food safety and human health. Wheat gluten (WG) is considered as a valuable protein source in fish feed due to its suitability as a feed binder, high digestibility, good amino acid profile, energy density and most importantly, due to its relatively low level of anti-nutritional factors (ANFs). The main aim of this ...
DOI:
10.3390/genes11111339

14. Transcriptome sequencing of hybrid bester sturgeon: Responses to poly (I:C) in the context of comparative immunogenomics

Author:
Aleksei Krasnov,   et al.   ; Nikolai Mugue; Nadezhda Terekhanova; Sergey Afanasyev;     Show all 4 Authors
Source:
Fish & shellfish immunology 2019 v.93 pp. 888-894
ISSN:
1050-4648
Subject:
Acipenser ruthenus; Huso huso; Salmo salar; acute phase proteins; apoptosis; binding proteins; biochemical pathways; cell cycle; databases; double-stranded RNA; gene expression regulation; genes; genomics; gills; heme; hybrids; immunity; interferons; iron; kidneys; mammals; moieties; phylogeny; salmon; sequence analysis; spleen; sturgeon; tetratricopeptide repeats; transcription (genetics); transcriptome; transcriptomics; transferrin
Abstract:
... Sturgeons represent a substantial scientific interest due to their high economic value, endangered status and also as the most primitive group of ray-finned fishes. Rapid progress in knowledge of sturgeon immunity was achieved recently with use of RNA sequencing. We report transcriptome sequencing of gill, head kidney, and spleen of bester sturgeon (a hybrid of beluga Huso huso and sterlet Acipens ...
DOI:
10.1016/j.fsi.2019.08.038

15. Morphology, Transcriptomics and In Vitro Model of Skin from Polar Cod (Boreogadus Saida) and Atlantic Cod (Gadus Morhua)

Author:
Aleksei Krasnov,   et al.   ; Elisabeth Ytteborg; Øyvind Johannes Hansen; Vibeke Høst; Sergey Afanasyev; Ireen Vieweg; Jasmine Nahrgang;     Show all 7 Authors
Source:
Fishes 2020 v.5 no.4 pp. 34
ISSN:
2410-3888
Subject:
Boreogadus saida; Gadus morhua; cell culture; cell movement; dose response; fish; fish skin; gene expression regulation; hydrogen peroxide; microarray technology; models; transcriptome; transcriptomics
Abstract:
... Fish skin is a multifunctional barrier tissue with high regeneration capacity that interacts with the surrounding environment and provides protection. Functional importance, high complexity and activity make skin an attractive tissue for studying the effects of environmental challenges and chemical stressors in fish. The aim of this work was to characterize skin from polar cod (Boreogadus saida) a ...
DOI:
10.3390/fishes5040034

16. Oxidative Chemical Stressors Alter the Physiological State of the Nasal Olfactory Mucosa of Atlantic Salmon

Author:
Aleksei Krasnov,   et al.   ; Carlo C. Lazado; Vibeke Voldvik; Mette W. Breiland; João Osório; Marianne H. S. Hansen;     Show all 6 Authors
Source:
Antioxidants 2020 v.9 no.11 pp. -
ISSN:
2076-3921
Subject:
Salmo salar; acetic acid; antioxidant activity; aquaculture; cytokines; disinfection; dosage; extracellular matrix; fish; genes; heat shock proteins; hydrogen peroxide; immune response; leukocytes; microarray technology; models; mucosa; nose; olfactory organs; oxidants; oxidative stress; pathogens; peracetic acid; physiological state; trade; transcription (genetics)
Abstract:
... The olfactory organs of fish have vital functions for chemosensory and defence. Though there have been some ground-breaking discoveries of their involvement in immunity against pathogens in recent years, little is known about how they respond to non-infectious agents, such as exogenous oxidants, which fish encounter regularly. To this end, we employed Atlantic salmon (Salmo salar) as a model to st ...
DOI:
10.3390/antiox9111144

17. Ig-seq: deep sequencing of the variable region of Atlantic salmon IgM heavy chain transcripts

Author:
Aleksei Krasnov,   et al.   ; Sven Martin Jørgensen; Sergey Afanasyev;     Show all 3 Authors
Source:
Molecular Immunology 2017 pp. -
ISSN:
0161-5890
Subject:
muscular diseases; immunoglobulin M; nucleotides; fish; blood; Salmo salar; antibodies; binding properties; viruses; pathogens; stop codon; antigens; high-throughput nucleotide sequencing; amino acid sequences; transcription (genetics); kidneys; loci; seawater; genetic variation; smoltification
Abstract:
... Immunoglobulin M plays a key role in systemic protection of Atlantic salmon against pathogens. Until recent, studies have focused on antigen-specific antibodies and little is known about the IgM repertoire: its size, developmental changes and responses to antigens. We report the development of deep sequencing protocol to characterize the repertoire of IgM heavy chain variable region. Its structure ...
DOI:
10.1016/j.molimm.2017.06.022

18. Choline and phosphatidylcholine, but not methionine, cysteine, taurine and taurocholate, eliminate excessive gut mucosal lipid accumulation in Atlantic salmon (Salmo salar L)

Author:
Aleksei Krasnov,   et al.   ; Åshild Krogdahl; Anne Kristine Grostøl Hansen; Trond M. Kortner; Ingemar Bjӧrkhem; Gerd M. Berge; Vegard Denstadli;     Show all 7 Authors
Source:
Aquaculture 2020 v.528 pp. 735552
ISSN:
0044-8486
Subject:
Salmo salar; antigen presentation; biochemical pathways; chemokines; cholesterol; choline; cysteine; digestibility; droplets; enterocytes; extracellular enzymes; feed supplements; fish; fish feeding; fish meal; freshwater; gene expression regulation; genes; ingredients; lipid metabolism; lipoproteins; malabsorption; methionine; phosphatidylcholines; proteinases; seawater; taurine
Abstract:
... Excessive enterocyte lipid accumulation, with the suggested term lipid malabsorption syndrome (LMS), is frequently observed in Atlantic salmon (Salmo salar L), in small fish in fresh water as well as in large fish in seawater. The symptoms indicate insufficient supply of components involved in lipid assimilation. The questions addressed in the present work were whether dietary supply of components ...
DOI:
10.1016/j.aquaculture.2020.735552

19. Consequences of Haemorrhagic Smolt Syndrome (HSS) for the Immune Status of Atlantic salmon (Salmo salar L.) (Case Study)

Author:
Aleksei Krasnov,   et al.   ; Ingunn Sommerset; Tina Søfteland; Sergey Afanasyev; Preben Boysen; Hege Lund;     Show all 6 Authors
Source:
Biology 2019 v.9 no.1 pp. -
ISSN:
2079-7737
Subject:
Aeromonas salmonicida; B-lymphocytes; Moritella viscosa; Salmo salar; acute phase proteins; antibodies; bacterial infections; bioavailability; biochemical pathways; case studies; complement; etiology; fish; fish culture; fish diseases; freshwater; gene expression regulation; genes; heme; hemocyanin; hemorrhage; humoral immunity; immunoglobulin M; inflammation; iron; kidneys; lectins; limpets; messenger RNA; microarray technology; mortality; nephrocalcinosis; protein content; seawater; tumor necrosis factor receptors; vaccines; vitamin A
Abstract:
... Haemorrhagic smolt syndrome (HSS) is a disorder of unknown aetiology causing losses in the fresh water phase of Atlantic salmon farming. Normally, the mortality is limited and symptoms disappear upon seawater exposure. In this case study, classical HSS pathology with internal organ haemorrhages and nephrocalcinosis was diagnosed, and the losses were substantial. Microarray analyses of head kidney ...
DOI:
10.3390/biology9010001

20. A time-course study of gene expression and antibody repertoire at early time post vaccination of Atlantic salmon

Author:
Aleksei Krasnov,   et al.   ; Hege Lund; Anne Flore Bakke; Ingunn Sommerset; Sergey Afanasyev; Geir Schriwer; Audur Thorisdottir; Preben Boysen;     Show all 8 Authors
Source:
Molecular immunology 2019 v.106 pp. 99-107
ISSN:
0161-5890
Subject:
Aeromonas salmonicida; B-lymphocytes; Moritella viscosa; Salmo salar; antibodies; antigens; blood plasma; gene expression regulation; genes; genetic markers; immunoglobulin M; kidneys; messenger RNA; parr; salmon; vaccination; vaccines; variance
Abstract:
... The majority of studies of vaccine responses in Atlantic salmon have focused on several weeks after vaccination, and employed a limited number of marker genes. In this study, novel techniques were used to examine a broad panel of expressed genes and antibody repertoire of Atlantic salmon following vaccination. Salmon parr were vaccinated with a multivalent oil-based vaccine, and blood plasma and h ...
DOI:
10.1016/j.molimm.2018.12.018