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- Alfieri, Carolina, et al. Show all 8 Authors
- Genome biology 2016 v.17 no.1 pp. 246
- ancestry; enzymes; genes; haplotypes; human population; humans; innate immunity; introgression; loci; people; transcription (genetics); Africa
- ... BACKGROUND: The 2’-5’ oligoadenylate synthetase (OAS) locus encodes for three OAS enzymes (OAS1-3) involved in innate immune response. This region harbors high amounts of Neandertal ancestry in non-African populations; yet, strong evidence of positive selection in the OAS region is still lacking. RESULTS: Here we used a broad array of selection tests in concert with neutral coalescent simulations ...
- PubMed Central: