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- Amao, Michiko, et al. Show all 6 Authors
- Analytical biochemistry 2015 v.472 pp. 45-51
- cultured cells; glucagon-like peptide 1; glucose; hormone secretion; liquid chromatography; monitoring; noninsulin-dependent diabetes mellitus; patients; secretin; sucralose; tandem mass spectrometry
- ... Glucagon-like peptide-1 (GLP-1) is an incretin peptide that regulates islet hormone secretion. During recent years, incretin-based therapies have been widely used for patients with type 2 diabetes. GLP-1 peptides undergo N- and C-terminal processing for gain or loss of functions. We developed a method to quantify picomolar quantities of intact GLP-1 peptides using liquid chromatography–tandem mass ...