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- Ananthanarayanan, Badriprasad, et al. Show all 6 Authors
- Langmuir 2016 v.32 no.23 pp. 5990-5996
- aspartic acid; electrostatic interactions; ionic strength; microscopy; peptides; phosphorylation; proteins; serine
- ... Intrinsically disordered proteins (IDPs) are an important and emerging class of materials for tailoring biointerfaces. While the importance of chain charge and resultant electrostatic interactions in controlling conformational properties of IDPs is beginning to be explored through in silico approaches, there is a dearth of experimental studies motivated toward a systematic study of these effects. ...
- Ananthanarayanan, Badriprasad, et al. Show all 9 Authors
- Biomaterials 2017
- Parkinson disease; brain; cell viability; clinical trials; encapsulation; heparin; humans; hyaluronic acid; hydrogels; manufacturing; models; neurons; phenotype; rats; stem cells
- ... Cell replacement therapies have broad biomedical potential; however, low cell survival and poor functional integration post-transplantation are major hurdles that hamper clinical benefit. For example, following striatal transplantation of midbrain dopaminergic (mDA) neurons for the treatment of Parkinson's disease (PD), only 1–5% of the neurons typically survive in preclinical models and in clinic ...
- Ananthanarayanan, Badriprasad, et al. Show all 3 Authors
- Biomaterials 2011 v.32 no.31 pp. 7913-7923
- actin; biophysics; brain; cell adhesion; extracellular matrix; hyaluronic acid; hydrocolloids; mechanics; microstructure; models; neoplasm cells; neoplasms; parenchyma; peptides; porosity
- ... Glioblastoma multiforme (GBM) is a malignant brain tumor characterized by diffuse infiltration of single cells into the brain parenchyma, which is a process that relies in part on aberrant biochemical and biophysical interactions between tumor cells and the brain extracellular matrix (ECM). A major obstacle to understanding ECM regulation of GBM invasion is the absence of model matrix systems that ...
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