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1. Validation of microSecure vitrification (μS-VTF) for the effective cryopreservation of human embryos and oocytes

Author:
Anderson, Robert E.,   et al.   ; Schiewe, Mitchel C.; Zozula, Shane; Fahy, Gregory M.;     Show all 4 Authors
Source:
Cryobiology 2015 v.71 no.2 pp. 264-272
ISSN:
0011-2240
Subject:
blastocyst; cooling; cryopreservation; embryo transfer; freezing; humans; microprocessors; oocytes; sucrose; viability; vitrification
Abstract:
... A novel, aseptic closed system vitrification (VTF) technique for the cryopreservation of embryos and oocytes has been developed and clinically validated in this study. It combines the practicality of embryo-containing sterile flexipettes stored safely and securely with 0.3ml CBS™ embryo straws possessing weld seals. The cooling and warming rates of this double container system were determined usin ...
DOI:
10.1016/j.cryobiol.2015.07.009

2. The p110α isoform of phosphoinositide 3-kinase is essential for cone photoreceptor survival

Author:
Anderson, Robert E.,   et al.   ; Rajala, Raju V.S.; Ranjo-Bishop, Michelle; Wang, Yuhong; Rajala, Ammaji;     Show all 5 Authors
Source:
Biochimie 2015 v.112 pp. 35-40
ISSN:
0300-9084
Subject:
color vision; cones (retina); inositols; lipids; phosphatidylinositol 3-kinase
Abstract:
... Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylates the 3′OH of the inositol ring of phosphoinositides (PIs). They are responsible for coordinating a diverse range of cellular functions. Class IA PI3K is a heterodimeric protein composed of a regulatory p85 and a catalytic p110 subunit. In this study, we conditionally deleted the p110α-subunit of PI3K in cone photor ...
DOI:
10.1016/j.biochi.2015.02.018
PubMed:
25742742
PubMed Central:
PMC4402270

3. Deciphering mutant ELOVL4 activity in autosomal-dominant Stargardt macular dystrophy

Author:
Anderson, Robert E.,   et al.   ; Logan, Sreemathi; Agbaga, Martin-Paul; Chan, Michael D.; Kabir, Nabila; Mandal, Nawajes A.; Brush, Richard S.;     Show all 7 Authors
Source:
Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.14 pp. 5446-5451
ISSN:
0027-8424
Subject:
brain; condensation reactions; endoplasmic reticulum; enzyme activity; genes; macular degeneration; mutants; mutation; polyunsaturated fatty acids; toxicity
Abstract:
... Autosomal-dominant Stargardt-like macular dystrophy [Stargardt3 (STGD3)] results from single allelic mutations in the elongation of very-long–chain fatty acids-like 4 (ELOVL4), whereas recessive mutations lead to skin and brain dysfunction. ELOVL4 protein localizes to the endoplasmic reticulum, where it mediates the condensation reaction catalyzing the formation of very-long–chain (VLC) (C-28 to C ...
DOI:
10.1073/pnas.1217251110
PubMed:
23509295
PubMed Central:
PMC3619277

4. Comparison of methods for estimating the spread of a non-indigenous species

Author:
Anderson Roberts, E.,   et al.   ; Tobin, Patrick C.; Liebhold, Andrew M.;     Show all 3 Authors
Source:
Journal of biogeography 2007 v.34 no.2 pp. 305-312
ISSN:
0305-0270
Subject:
Lymantria dispar; climate change; introduced species; invasive species; pheromone traps; trapping; United States
Abstract:
... To compare different quantitative approaches for estimating rates of spread in the exotic species gypsy moth, Lymantria dispar L., using county-level presence/absence data and spatially extensive trapping grids. USA We used county-level presence/absence records of the gypsy moth's distribution in the USA, which are available beginning in 1900, and extensive grids of pheromone-baited traps, which a ...
DOI:
10.1111/j.1365-2699.2006.01600.x

5. Environmental light and heredity are associated with adaptive changes in retinal DHA levels that affect retinal function

Author:
Anderson, Robert E.,   et al.   ; Penn, John S.;     Show all 2 Author
Source:
Lipids 2004 v.39 no.11 pp. 1121-1124
ISSN:
0024-4201
Subject:
cell death; inheritance (genetics); mice; rats; retina; rhodopsin; vision
Abstract:
... Retinas of rats and mice react to environmental and genetic stimuli by altering the level of DHA in their rod outer segment membranes. We propose that this adaptation is a neuroprotective response to control the number of photons captured by rhodopsin and the efficiency of visual transduction, under conditions where excessive activation of the transduction cascade could lead to cell death. ...
DOI:
10.1007/s11745-004-1338-8

6. Effects of SPLAT® GM sprayable pheromone formulation on gypsy moth mating success

Author:
Anderson Roberts, E.,   et al.   ; Onufrieva, Ksenia S.; Thorpe, Kevin W.; Hickman, Andrea D.; Tobin, Patrick C.; Leonard, Donna S.;     Show all 6 Authors
Source:
Entomologia experimentalis et applicata 2010 v.136 no.2 pp. 109-115
ISSN:
0013-8703
Subject:
Lymantria dispar; active ingredients; bait traps; disparlure; females; forests; insect pests; integrated pest management; introduced species; males; mating disruption; moths; pheromone traps; reproductive success; sex pheromones; Virginia
Abstract:
... Several integrated pest management programs rely on the use of mating disruption tactics to control insect pests. Some programs specifically target non-native species, such as the gypsy moth, Lymantria dispar (L.) (Lepidoptera: Lymantriidae). We evaluated SPLAT® GM, a new sprayable formulation of the gypsy moth sex pheromone disparlure, for its ability to disrupt gypsy moth mating. The study was c ...
DOI:
10.1111/j.1570-7458.2010.01009.x

7. Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids

Author:
Anderson, Robert E.,   et al.   ; Agbaga, Martin-Paul; Brush, Richard S.; Mandal, Md Nawajes A.; Henry, Kimberly; Elliott, Michael H.;     Show all 6 Authors
Source:
Proceedings of the National Academy of Sciences of the United States of America 2008 v.105 no.35 pp. 12843-12848
ISSN:
0027-8424
Subject:
macular degeneration; cell death; epithelium; photoreceptors; juveniles; phenotype; brain; patients; saturated fatty acids; spermatozoa; long chain polyunsaturated fatty acids; humans; mutation; mice; retina; rats; exons; biosynthesis; cardiomyocytes; polyunsaturated fatty acids; very long chain fatty acids; vision
Abstract:
... Stargardt-like macular dystrophy (STGD3) is a dominantly inherited juvenile macular degeneration that eventually leads to loss of vision. Three independent mutations causing STGD3 have been identified in exon six of a gene named Elongation of very long chain fatty acids 4 (ELOVL4). The ELOVL4 protein was predicted to be involved in fatty acid elongation, although evidence for this and the specific ...
DOI:
10.1073/pnas.0802607105
PubMed:
18728184
PubMed Central:
PMC2525561