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- Annereau, JeanâPhilippe, et al. Show all 8 Authors
- European journal of biochemistry 2000 v.267 no.17 pp. 5306-5312
- adenosinetriphosphatase; cystic fibrosis; fluorescence; genes; histidine; multiple drug resistance; mutation; nuclear magnetic resonance spectroscopy; patients; structure-activity relationships; transporters; tryptophan
- ... Cystic fibrosis is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). This protein belongs to the large ATPâbinding cassette (ABC) family of transporters. Most patients with cystic fibrosis bear a mutation in the nucleotideâbinding domain 1 (NBD1) of CFTR, which plays a key role in the activation of the channel function of CFTR. Determinati ...