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- Ashour, Joseph, et al. Show all 7 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.16 pp. 6406-6411
- Orthomyxoviridae; antibodies; biochemical pathways; glycoproteins; hemagglutinins; influenza; physiological transport; serine C-palmitoyltransferase; sialidase; sphingomyelins; trypsin; viral proteins; virion; viruses
- ... Cells genetically deficient in sphingomyelin synthase-1 (SGMS1) or blocked in their synthesis pharmacologically through exposure to a serine palmitoyltransferase inhibitor (myriocin) show strongly reduced surface display of influenza virus glycoproteins hemagglutinin (HA) and neuraminidase (NA). The transport of HA to the cell surface was assessed by accessibility of HA on intact cells to exogenou ...
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