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- Ashraf Talesh, Seyed Siamak, et al. Show all 6 Authors
- Journal of chromatography 2019 v.1113 pp. 20-29
- Western blotting; agarose; anion exchange chromatography; dissociation; electrical conductivity; hepatitis B; hepatitis B antigens; ionic strength; medicine; polyacrylamide gel electrophoresis; quantitative analysis; recombinant vaccines; transmission electron microscopy; virus-like particles
- ... Production of recombinant HBsAg as a main component of the hepatitis B vaccine has already been established in commercial scale. So far, many studies have been performed to optimize the production process of this recombinant vaccine. However, still aggregation and dissociation of rHBsAg virus-like particles (VLPs) are major challenges in downstream processing of this biomedicine. The structural di ...