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1. Comparison of tropomyosin released peptide and epitope mapping after in vitro digestion from fish (Larimichthys crocea), shrimp (Litopenaeus vannamei) and clam (Ruditapes philippinarum) through SWATH-MS based proteomics

Author:
LiLi Xu; Xiao Mei Zhang; Yun Qi Wen; Jin Long Zhao; Tong Cheng Xu; Ling Yong; Hong Lin; Hong Wei Zhang; Zhen Xing Li
Source:
Food chemistry 2023 v.403 pp. 134314
ISSN:
0308-8146
Subject:
B-lymphocytes,   etc   ; Larimichthys crocea; Litopenaeus vannamei; Ruditapes philippinarum; allergenicity; allergens; anaphylaxis; clams; digestion; epitopes; fish; food chemistry; gastric juice; gastrointestinal system; intestinal secretions; pepsin; peptides; proteomics; shellfish; shrimp; tropomyosins;     Show all 21 Subjects
Abstract:
... Tropomyosin (TM) is a major shellfish allergen and a minor fish allergen. Different digestion profiles affect potential allergen anaphylaxis of protein. In this study, released peptides of fish-TM, shrimp-TM, and clam-TM by in vitro digestion of simulated gastric fluid (SGF), simulated intestinal fluid (SIF), and gastrointestinal (GI) were analyzed using sequential windowed acquisition of all theo ...
DOI:
10.1016/j.foodchem.2022.134314

2. CD4+ Cytotoxic T Cells Involved in the Development of EBV-Associated Diseases

Author:
Manuel Ruiz-Pablos
Source:
Pathogens 2022 v.11 no.8 pp. -
ISSN:
2076-0817
Subject:
B-lymphocytes,   etc   ; antiviral agents; cytotoxicity; risk;     Show all 4 Subjects
Abstract:
... Activated cytotoxic CD4 T cells (HLA-DR+) play an important role in the control of EBV infection, especially in cells with latency I (EBNA-1). One of the evasion mechanisms of these latency cells is generated by gp42, which, via peripherally binding to the β1 domain of the β chain of MHC class II (HLA-DQ, -DR, and -DP) of the infected B lymphocyte, can block/alter the HLA class II/T-cell receptor ...
DOI:
10.3390/pathogens11080831

3. Locally produced autoantibodies in cancer

Author:
Sara M. Centuori; Deepta Bhattacharya
Source:
Cell 2022 v.185 no.7 pp. 1110-1111
ISSN:
0092-8674
Subject:
B-lymphocytes,   etc   ; antibody formation; autoantibodies; metalloproteinases;     Show all 4 Subjects
Abstract:
... The function and antigen-specificities of tumor-infiltrating B cells are mostly unknown. In a new study by Mazor et al., matrix metalloproteinase 14 (MMP14), a self-antigen that is overexpressed by ovarian cancers, is shown to drive B cell activation and autoantibody production in tertiary lymphoid structures (Mazor et al., 2022). ...
DOI:
10.1016/j.cell.2022.03.006

4. A novel strategy to investigate the factors regulating the Treg to Tfr transition during acute viral infection

Author:
Huayu Lin; Haoqiang Wang; Qiao Liu; Zhiming Wang; Shuqiong Wen; Lisha Wang; Junyi Guo; Ling Ran; Zhengliang Yue; Qing Wu; Jianfang Tang; Zhirong Li; Li Hu; Lifan Xu; Qizhao Huang; Lilin Ye
Source:
Journal of immunological methods 2022 v.505 pp. 113266
ISSN:
0022-1759
Subject:
B-lymphocytes,   etc   ; chemokines; homeostasis; lymph nodes;     Show all 4 Subjects
Abstract:
... Follicular regulatory T cells (Tfrs), a specialized subset of regulatory T cells (Tregs), have a particular role in the control of follicular helper T cell-driven germinal center (GC) responses. Following differentiation signals similar to those received by follicular helper T cells (Tfhs), Tfrs gain expression of characteristic chemokine receptors and transcription factors, such as CXCR5 and Bcl- ...
DOI:
10.1016/j.jim.2022.113266

5. Optimization of peripheral blood volume for in silico reconstitution of the human B‐cell receptor repertoire

Author:
Hyunho Lee; Duck Kyun Yoo; Jerome Han; Ki Hyun Kim; Jinsung Noh; Yonghee Lee; Eunjae Lee; Sunghoon Kwon; Junho Chung
Source:
FEBS Open Bio 2022 v.12 no.9 pp. 1634-1643
ISSN:
2211-5463
Subject:
B-lymphocytes,   etc   ; blood volume; computer simulation; humans;     Show all 4 Subjects
Abstract:
... B cells recognize antigens via membrane‐expressed B‐cell receptors (BCR) and antibodies. Similar human BCR sequences are frequently found at a significantly higher frequency than that theoretically calculated. Patients infected with SARS‐CoV2 and HIV or with autoimmune diseases share very similar BCRs. Therefore, in silico reconstitution of BCR repertoires and identification of stereotypical BCR s ...
DOI:
10.1002/2211-5463.13467

6. Anti-Toxoplasma gondii IgM Long Persistence: What Are the Underlying Mechanisms?

Author:
José Antonio Vargas-Villavicencio; Irma Cañedo-Solares; Dolores Correa
Source:
Microorganisms 2022 v.10 no.8 pp. -
ISSN:
2076-2607
Subject:
B-lymphocytes,   etc   ; Toxoplasma gondii; antibodies; immunoglobulins; parasites;     Show all 5 Subjects
Abstract:
... Diagnosis of Toxoplasma gondii acute infection was first attempted by detection of specific IgM antibodies, as for other infectious diseases. However, it was noted that this immunoglobulin declines slowly and may last for months or even years. Apart from the diagnostic problem imposed on clinical management, this phenomenon called our attention due to the underlying phenomena that may be causing i ...
DOI:
10.3390/microorganisms10081659

7. Three new pyrrole alkaloids from the endophytic fungus Albifimbria viridis

Author:
Pan-Pan Wei; Jia-Cheng Ji; Xu-Jun Ma; Zheng-Hui Li; Hong-Lian Ai; Xin-Xiang Lei; Ji-Kai Liu
Source:
Natural products and bioprospecting 2022 v.12 no.1 pp. 5
ISSN:
2192-2195
Subject:
B-lymphocytes,   etc   ; endophytes; fungi; immunosuppression; medicinal plants; pyrroles;     Show all 6 Subjects
Abstract:
... Three new pyrrole alkaloids albifipyrrols A–C (1–3), were isolated from the endophytic fungus Albifimbria viridis collected from the Chinese medicinal plant. Their structures were elucidated by extensive NMR and HRESIMS spectrometric analyses. All compounds were evaluated for immunosuppressive activity. Fortunately, compound 2 exhibits certain inhibition specifically against the LPS-induced prolif ...
DOI:
10.1007/s13659-022-00327-2

8. Cytomegalovirus infection may be oncoprotective against neoplasms of B-lymphocyte lineage: single-institution experience and survey of global evidence

Author:
Marko Janković; Aleksandra Knežević; Milena Todorović; Irena Đunić; Biljana Mihaljević; Ivan Soldatović; Jelena Protić; Nevenka Miković; Vera Stoiljković; Tanja Jovanović
Source:
Virology journal 2022 v.19 no.1 pp. 155
ISSN:
1743-422X
Subject:
B-lymphocytes,   etc   ; Cytomegalovirus infections; leukemia; lymphoma; seroprevalence; surveys; virology;     Show all 7 Subjects
Abstract:
... BACKGROUND: Although cytomegalovirus (CMV) is not considered tumorigenic, there is evidence for its oncomodulatory effects and association with hematological neoplasms. Conversely, a number of experimental and clinical studies suggest its putative anti-tumour effect. We investigated the potential connection between chronic CMV infection in patients with B-lymphocyte (B-cell) malignancies in a retr ...
DOI:
10.1186/s12985-022-01884-1

9. The Importance of the Bursa of Fabricius, B Cells and T Cells for the Pathogenesis of Marek’s Disease: A Review

Author:
Karel A. Schat
Source:
Viruses 2022 v.14 no.9 pp. -
ISSN:
1999-4915
Subject:
B-lymphocytes,   etc   ; bursa of Fabricius; irradiation; models; pathogenesis; viruses;     Show all 6 Subjects
Abstract:
... The importance of the bursa of Fabricius (BF) for the pathogenesis of Marek’s disease (MD) has been studied since the late 1960’s. In this review, the results of these studies are analyzed in the context of the developing knowledge of the immune system of chickens and the pathogenesis of MD from 1968 to 2022. Based on the available techniques to interfere with the development of the BF, three dist ...
DOI:
10.3390/v14092015

10. Monitoring B cell alloresponses in rats

Author:
Louisa Steines; Mona Scharf; Petra Hoffmann; Antonia Schuster; Bernhard Banas; Tobias Bergler
Source:
Journal of immunological methods 2022 v.501 pp. 113212
ISSN:
0022-1759
Subject:
B-lymphocytes,   etc   ; cell proliferation; memory; organ transplantation; rats; splenocytes;     Show all 6 Subjects
Abstract:
... Antibody-mediated rejection is a major cause of graft failure in organ transplantation. For this reason, B cell responses are of particular interest to transplantation research. Rats are important model organisms for transplant studies, but B cell alloimmune assays and B cell subset markers are poorly established in rats. We alloimmunized rats by donor blood injection using the high responder rat ...
DOI:
10.1016/j.jim.2021.113212

11. Nfkbid-mediated humoral immunity during secondary toxoplasmosis

Author:
Imtiaz A. Khan; Magali Moretto
Source:
Trends in parasitology 2022 v.38 no.4 pp. 272-273
ISSN:
1471-4922
Subject:
B-lymphocytes,   etc   ; Toxoplasma gondii; genetics; humoral immunity; parasitology; toxoplasmosis;     Show all 6 Subjects
Abstract:
... Vaccine-mediated immunity to parasites has not been achieved. Immune C57BL/6 mice are susceptible to secondary Toxoplasma gondii infection. Using a forward genetics approach, Souza et al. identify Nfkbid as an important factor for the regulation of B cell immunity during secondary Toxoplasma infection and protection against rechallenge. ...
DOI:
10.1016/j.pt.2022.01.010

12. Meta-analysis of microRNA profiling data does not reveal a consensus signature for B cell acute lymphoblastic leukemia

Author:
Modeline N. Longjohn; Willow R.B. Squires; Sherri L. Christian
Source:
Gene 2022 v.821 pp. 146211
ISSN:
0378-1119
Subject:
B-lymphocytes,   etc   ; data collection; genes; lymphocytic leukemia; meta-analysis; microRNA;     Show all 6 Subjects
Abstract:
... B cell acute lymphoblastic leukemia (B-ALL) is the most prevalent pediatric cancer. MicroRNAs (miRNAs) are 18-22nt non-coding transcripts shown to be essential for the development of many cancers. While some miRNAs are reportedly expressed differentially between healthy and B-ALL, no studies have reported a consensus miRNA signature. Therefore, we performed a reanalysis of five miRNA datasets to i ...
DOI:
10.1016/j.gene.2022.146211

13. Changes in rabbit lymphocyte subpopulations and activation following long-term administration of meloxicam

Author:
Pavla Hamouzová; Šárka Stehlíková; Kristína Řeháková; Vladimír Jekl; Jan Chloupek; Jaroslav Doubek
Source:
Veterinary immunology and immunopathology 2022 v.253 pp. 110496
ISSN:
0165-2427
Subject:
B-lymphocytes,   etc   ; analgesics; flow cytometry; hematology; immunology; immunopathology; meloxicam; rabbits;     Show all 8 Subjects
Abstract:
... Meloxicam is a commonly used analgesic in rabbits. However, its possible impact on lymphocyte subpopulations remained unknown. The aim of the study was to investigate a possible effect of long-term administration of meloxicam on rabbit lymphocyte subpopulations. The study included 8 rabbits given meloxicam orally once daily (1 mg/kg BW) for 14 days and 8 rabbits as a control group. Peripheral bloo ...
DOI:
10.1016/j.vetimm.2022.110496

14. The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance

Author:
Raji E. Joseph; Jacques Lowe; D. Bruce Fulton; John R. Engen; Thomas E. Wales; Amy H. Andreotti
Source:
Journal of molecular biology 2022 v.434 no.5 pp. 167422
ISSN:
0022-2836
Subject:
B-lymphocytes,   etc   ; conformational isomerization; drug resistance; enzymes; molecular biology; phosphorylation; tyrosine;     Show all 7 Subjects
Abstract:
... Mutations in PLCγ, a substrate of the tyrosine kinase BTK, are often found in patients who develop resistance to the BTK inhibitor Ibrutinib. However, the mechanisms by which these PLCγ mutations cause Ibrutinib resistance are unclear. Under normal signaling conditions, BTK mediated phosphorylation of Y783 within the PLCγ cSH2-linker promotes the intramolecular association of this site with the ad ...
DOI:
10.1016/j.jmb.2021.167422

15. Primary Intestinal Lymphoma in Rabbits

Author:
Jessica Magnotti; Daniel Bland; Michael M. Garner; Alana S. Frum; Jennifer Phinney; Brandon L. Plattner; Elise EB. LaDouceur
Source:
Journal of comparative pathology 2022 v.195 pp. 28-33
ISSN:
0021-9975
Subject:
B-lymphocytes,   etc   ; B-cell lymphoma; World Health Organization; immune response; intestines;     Show all 5 Subjects
Abstract:
... Neoplasms of the intestinal tract are uncommon in rabbits and primary lymphoma of the intestinal tract is rare. This case series is the first detailed description of primary intestinal lymphoma in rabbits. We reviewed four cases of primary intestinal lymphoma in rabbits aged 5–9.5 years old with an average age of 7.8 years. Neoplastic cells in three cases were large (8 μm diameter) while one case ...
DOI:
10.1016/j.jcpa.2022.05.004

16. Bidirectional feedback between BCR signaling and actin cytoskeletal dynamics

Author:
Anshuman Bhanja; Ivan Rey‐Suarez; Wenxia Song; Arpita Upadhyaya
Source:
FEBS journal 2022 v.289 no.15 pp. 4430-4446
ISSN:
1742-464X
Subject:
B-lymphocytes,   etc   ; actin; antigens; diffusivity; endocytosis; microfilaments; microscopy; myosin; transcription (genetics);     Show all 9 Subjects
Abstract:
... When B cells are exposed to antigens, they use their B‐cell receptors (BCRs) to transduce this external signal into internal signaling cascades and uptake antigen, which activate transcriptional programs. Signaling activation requires complex cytoskeletal remodeling initiated by BCR signaling. The actin cytoskeletal remodeling drives B‐cell morphological changes, such as spreading, protrusion, con ...
DOI:
10.1111/febs.16074

17. Ophiorrhines F and G, Key Biogenetic Intermediates of Ophiorrhine Alkaloids from Ophiorrhiza japonica and Their Immunosuppressant Activities

Author:
Bao-bao Shi; Hong-Lian Ai; Kai-Ting Duan; Tao Feng; Ji-Kai Liu
Source:
Journal of natural products 2022 v.85 no.2 pp. 453-457
ISSN:
1520-6025
Subject:
B-lymphocytes,   etc   ; Ophiorrhiza; cell proliferation; circular dichroism spectroscopy; immunosuppression; immunosuppressive agents;     Show all 6 Subjects
Abstract:
... Continued interest in bioactive alkaloids led to the isolation of two undescribed alkaloids, ophiorrhines F (1) and G (2), from the aerial parts of Ophiorrhiza japonica. Their structures were elucidated based on spectroscopic methods, electronic circular dichroism, and calculated NMR with DP4+ analysis. These two alkaloids represent key biological genetic intermediates in the formation of ring C i ...
DOI:
10.1021/acs.jnatprod.1c01085

18. Single-cell isoform analysis in human immune cells

Author:
Roger Volden; Christopher Vollmers
Source:
Genome biology 2022 v.23 no.1 pp. 47
ISSN:
1474-760X
Subject:
B-lymphocytes,   etc   ; T-lymphocytes; genome; genomics; humans; immunologic receptors; monocytes; transcriptome;     Show all 8 Subjects
Abstract:
... High-throughput single-cell analysis today is facilitated by protocols like the 10X Genomics platform or Drop-Seq which generate cDNA pools in which the origin of a transcript is encoded at its 5′ or 3′ end. Here, we used R2C2 to sequence and demultiplex 12 million full-length cDNA molecules generated by the 10X Genomics platform from ~3000 peripheral blood mononuclear cells. We use these reads, i ...
DOI:
10.1186/s13059-022-02615-z

19. The order of immunoglobulin light chain κ and λ usage in primary and secondary lymphoid tissues of germ-free and conventional piglets

Author:
Katerina Stepanova; Jana Sinkorova; Dagmar Srutkova; Marek Sinkora; Simon Sinkora; Igor Splichal; Alla Splichalova; John E. Butler
Source:
Developmental and comparative immunology 2022 v.131 pp. 104392
ISSN:
0145-305X
Subject:
B-lymphocytes,   etc   ; Sus scrofa; antigens; bone marrow; genes; immunoglobulin light chains;     Show all 6 Subjects
Abstract:
... In pigs (Sus scrofa), the initial immunoglobulin rearrangement of the κ light chain is replaced by λ before the heavy chains rearrange, and the light chains may rearrange even later. This study investigates whether these developmental differences are reflected in the usage of IGK and IGL genes. We found large differences between peripheral B cells and those developing in the bone marrow, and betwe ...
DOI:
10.1016/j.dci.2022.104392

20. ASIC1a promotes hepatic stellate cell activation through the exosomal miR-301a-3p/BTG1 pathway

Author:
Shao-hua Luan; Yu-qing Yang; Man-ping Ye; Hui Liu; Qiu-fan Rao; Jin-ling Kong; Fan-rong Wu
Source:
International journal of biological macromolecules 2022 v.211 pp. 128-139
ISSN:
0141-8130
Subject:
B-lymphocytes,   etc   ; exosomes; genes; information exchange; ion channels; liver cirrhosis; microRNA; transcriptome;     Show all 8 Subjects
Abstract:
... Activation of hepatic stellate cells (HSCs) is a key cause of liver fibrosis. However, the mechanisms leading to the activation of HSCs are not fully understood. In the pathological process, acid-sensing ion channel 1a (ASIC1a) is widely involved in the development of inflammatory diseases, suggesting that ASIC1a may play an important role in liver fibrosis. We found that in an acidic environment, ...
DOI:
10.1016/j.ijbiomac.2022.05.041