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- Author:
- B. N. Keel, et al. ; J. W. Keele; W. M. Snelling; Show all 3 Authors
- Source:
- Animal genetics 2017 v.48 no.2 pp. 141-150
- ISSN:
- 0268-9146
- Subject:
- Angus; Charolais; Gelbvieh; Hereford; Red Angus; Simmental; algorithms; beef cattle; breed differences; bulls; data collection; genes; germplasm evaluation; nucleotide sequences; phenotype; purebreds; quantitative trait loci; sires; United States
- Abstract:
- ... Copy number variations (CNVs) are large insertions, deletions or duplications in the genome that vary between members of a species and are known to affect a wide variety of phenotypic traits. In this study, we identified CNVs in a population of bulls using low coverage next‐generation sequence data. First, in order to determine a suitable strategy for CNV detection in our data, we compared the per ...
- Handle:
- 10113/5717781
- DOI:
- 10.1111/age.12519
- https://doi.org/10.1111/age.12519
- Author:
- B. N. Keel, et al. ; D. J. Nonneman; G. A. Rohrer; Show all 3 Authors
- Source:
- Animal genetics 2017 v.48 no.4 pp. 404-411
- ISSN:
- 0268-9146
- Subject:
- Duroc; Yorkshire (swine breed); boars; genes; genetic variation; genomics; herds; landraces; loss-of-function mutation; phenotypic variation; sequence analysis; single nucleotide polymorphism; sows; surveys
- Abstract:
- ... Genetic variants detected from sequence have been used to successfully identify causal variants and map complex traits in several organisms. High and moderate impact variants, those expected to alter or disrupt the protein coded by a gene and those that regulate protein production, likely have a more significant effect on phenotypic variation than do other types of genetic variants. Hence, a compr ...
- Handle:
- 10113/5700708
- DOI:
- 10.1111/age.12557
- https://doi.org/10.1111/age.12557
- Author:
- B. N. Keel, et al. ; W. M. Snelling; L. A. Kuehn; R. M. Thallman; G. L. Bennett; Show all 5 Authors
- Source:
- Animal genetics 2017 v.48 no.5 pp. 516-522
- ISSN:
- 0268-9146
- Subject:
- breeding value; bulls; frequency distribution; gene frequency; genetic correlation; genetic distance; genetic variation; genotyping; haplotypes; linkage disequilibrium; marker-assisted selection; prediction; single nucleotide polymorphism; sires
- Abstract:
- ... Genomic prediction utilizing causal variants could increase selection accuracy above that achieved with SNPs genotyped by currently available arrays used for genomic selection. A number of variants detected from sequencing influential sires are likely to be causal, but noticeable improvements in prediction accuracy using imputed sequence variant genotypes have not been reported. Improvement in acc ...
- Handle:
- 10113/5801804
- DOI:
- 10.1111/age.12579
- https://doi.org/10.1111/age.12579
- Author:
- B. N. Keel, et al. ; A. P. Foote; C. M. Zarek; A. K. Lindholm-Perry; Show all 4 Authors
- Source:
- Journal of animal science 2017 v.95 no.10 pp. 4430-4439
- ISSN:
- 0021-8812
- Subject:
- Angus; absorption; alfalfa hay; animal growth; average daily gain; beef cattle; biochemical pathways; carbohydrate metabolism; chemokine receptors; corn; cytochrome P-450; dietary supplements; digestion; distillers grains; drugs; dry matter intake; enzyme activity; finishing; galactose; gene expression; gene expression regulation; gene ontology; genes; glutathione transferase; jejunum; linoleic acid; mucosa; nutrients; slaughter; steers; xenobiotics
- Abstract:
- ... The objective of this study was to determine the association of differentially expressed genes (DEG) in the jejunum of steers with average DMI and high or low ADG. Feed intake and growth were measured in a cohort of 144 commercial Angus steers consuming a finishing diet containing (on a DM basis) 67.8% dry-rolled corn, 20% wet distillers grains with solubles, 8% alfalfa hay, and 4.2% vitamin/miner ...
- Handle:
- 10113/5852193
- DOI:
- 10.2527/jas2017.1804
- CHORUS:
- 10.2527/jas2017.1804
- https://doi.org/10.2527/jas2017.1804
- Author:
- B. N. Keel, et al. ; H. R. Wijesena; C. A. Lents; J.-J. Riethoven; M. D. Trenhaile-Grannemann; J. F. Thorson; P. S. Miller; M. L. Spangler; S. D. Kachman; D. C. Ciobanu; Show all 10 Authors
- Source:
- Journal of Animal Science 2017 v.95 no.9 pp. 4196-4205
- ISSN:
- 1525-3163
- Subject:
- RNA; animal science; data collection; energy; gene expression; gene expression regulation; genetic variance; genetic variation; genomics; gilts; homeostasis; litter size; longevity; low calorie diet; phenotypic variation; prediction; probability; puberty
- Abstract:
- ... Genetic variants associated with traits such as age at puberty and litter size could provide insight into the underlying genetic sources of variation impacting sow reproductive longevity and productivity. Genomewide characterization and gene expression profiling were used using gilts from the University of Nebraska–Lincoln swine resource population (n = 1,644) to identify genetic variants associat ...
- DOI:
- 10.2527/jas.2016.1334
- CHORUS:
- 10.2527/jas.2016.1334
- https://doi.org/10.2527/jas.2016.1334
- Author:
- B. N. Keel, et al. ; H. R. Wijesena; C. A. Lents; J. J. Riethoven; M. D. Trehaile-Grannemann; J. F. Thorson; P. S. Miller; M. L. Spangler; S. D. Kachman; D. C. Ciobanu; Show all 10 Authors
- Source:
- Journal of animal science 2017 v.95 no.9 pp. 4196-4205
- ISSN:
- 0021-8812
- Subject:
- animal age; data collection; energy; gene expression regulation; genes; genetic variance; genetic variation; genomics; gilts; homeostasis; litter size; longevity; nutrition; phenotypic variation; prediction; probability; puberty; reproductive traits; sequence analysis; single nucleotide polymorphism; sows
- Abstract:
- ... Genetic variants associated with traits such as age at puberty and litter size could provide insight into the underlying genetic sources of variation impacting sow reproductive longevity and productivity. Genomewide characterization and gene expression profiling were used using gilts from the University of Nebraska–Lincoln swine resource population (n =1,644) to identify genetic variants associate ...
- Handle:
- 10113/5832852
- DOI:
- 10.2527/jas2016.1334
- https://doi.org/10.2527/jas2016.1334
- Author:
- B. N. Keel, et al. ; J. W. Keele; L. A. Kuehn; T. G. McDaneld; R. G. Tait; S. A. Jones; W. M. Snelling; Show all 7 Authors
- Source:
- Journal of animal science 2015 v.94 no.2 pp. 490-499
- ISSN:
- 0021-8812
- Subject:
- DNA; Fusobacterium necrophorum; acidosis; beef cattle; bicarbonates; blood; blood flow; carcass weight; cell movement; covariance; gene frequency; genes; genetic variation; glutamine; homeostasis; immune response; kidneys; liver; liver abscess; lungs; pH; phenotype; rumen; single nucleotide polymorphism; sires; United States
- Abstract:
- ... Fourteen percent of U.S. cattle slaughtered in 2011 had liver abscesses, resulting in reduced carcass weight, quality, and value. Liver abscesses can result from a common bacterial cause, Fusobacterium necrophorum, which inhabits rumen lesions caused by acidosis and subsequently escapes into the blood stream, is filtered by the liver, and causes abscesses in the liver. Our aim was to identify SNP ...
- Handle:
- 10113/62014
- DOI:
- 10.2527/jas.2015-9887
- https://doi.org/10.2527/jas.2015-9887