Jump to Main Content
- Badylak, S.F., et al. Show all 11 Authors
- Biomaterials 2016 v.108 pp. 81-90
- adhesion; adverse effects; animal models; animal organs; bladder; crosslinking; extracellular matrix; hernia; rodents; strength (mechanics)
- ... The use of synthetic surgical mesh materials has been shown to decrease the incidence of hernia recurrence, but can be associated with undesirable effects such as infection, chronic discomfort, and adhesion to viscera. Surgical meshes composed of extracellular matrix (i.e., biologically-derived mesh) are an alternative to synthetic meshes and can reduce some of these undesirable effects but are le ...
- Badylak, S.F., et al. Show all 7 Authors
- Biomaterials 2012 v.33 no.1 pp. 91-101
- Toll-like receptor 4; anti-inflammatory activity; cell death; cell proliferation; chemokine CCL2; chemokine CCL4; correlated responses; crosslinking; death; encapsulation; extracellular matrix; gene expression; glycyrrhizin; immune response; inflammation; messenger RNA; secretion
- ... The immune response is an important determinant of the downstream remodeling of xenogeneic biologic scaffolds in vivo. Pro-inflammatory responses have been correlated with encapsulation and a foreign body reaction, while anti-inflammatory reactions are associated with constructive remodeling. However, the bioactive and bioinductive molecules within the extracellular matrix (ECM) that induce this p ...