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- Barak, Reut, et al. Show all 11 Authors
- Cell 2019 v.177 no.2 pp. 272-285.e16
- brain; crystal structure; dimerization; humans; ligands; mice; models; neurons; receptors
- ... Proper brain function requires high-precision neuronal expansion and wiring, processes controlled by the transmembrane Roundabout (Robo) receptor family and their Slit ligands. Despite their great importance, the molecular mechanism by which Robos’ switch from “off” to “on” states remains unclear. Here, we report a 3.6 Å crystal structure of the intact human Robo2 ectodomain (domains D1–8). We dem ...
- Barak, Reut, et al. Show all 6 Authors
- Journal of Molecular Biology 2017
- angiogenesis; cell movement; crystal structure; dimerization; disease course; dissociation; drugs; humans; hydrophobicity; kidney diseases; neoplasms; neurogenesis; receptors; ultracentrifugation
- ... Robo receptors play pivotal roles in axonal guidance as well as in neurogenesis, angiogenesis, cell migration, and cancer progression and invasiveness. They are considered to be attractive drug targets for the treatment of cancer, ocular neovascular disorders, chronic kidney diseases, and more. Despite their great importance, the mechanisms by which Robo receptors switch from their “off” to “on” s ...