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- Barnes, Ryan P., et al. Show all 6 Authors
- Molecular cell 2019 v.75 no.1 pp. 117-130.e6
- DNA replication; bioactive properties; cell growth; cell viability; chromatin; chronic exposure; genome; mitosis; oxidative stress; pleiotropy; reactive oxygen species; telomeres
- ... Telomeres are essential for genome stability. Oxidative stress caused by excess reactive oxygen species (ROS) accelerates telomere shortening. Although telomeres are hypersensitive to ROS-mediated 8-oxoguanine (8-oxoG) formation, the biological effect of this common lesion at telomeres is poorly understood because ROS have pleiotropic effects. Here we developed a chemoptogenetic tool that selectiv ...