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- Basu, Debashree, et al. Show all 7 Authors
- Cell 2019 v.176 no.6 pp. 1295-1309.e15
- DNA; DNA-directed DNA polymerase; carcinogenesis; genome; mice; point mutation; skin neoplasms
- ... Cancers from sun-exposed skin accumulate “driver” mutations, causally implicated in oncogenesis. Because errors incorporated during translesion synthesis (TLS) opposite UV lesions would generate these mutations, TLS mechanisms are presumed to underlie cancer development. To address the role of TLS in skin cancer formation, we determined which DNA polymerase is responsible for generating UV mutatio ...
- Basu, Debashree, et al. Show all 6 Authors
- Nucleic acids research 2009 v.37 no.15 pp. 4944-4954
- DNA; Mycobacterium tuberculosis; crosslinking; deoxyribonuclease I; fluorescent antibody technique; hydroxyl radicals; image analysis; nucleotide sequences; proteins
- ... The Mycobacterium tuberculosis genome sequence reveals remarkable absence of many nucleoid-associated proteins (NAPs), such as HNS, Hfq or DPS. In order to characterize the nucleoids of M. tuberculosis, we have attempted to identify NAPs, and report an interesting finding that a chaperonin-homolog, GroEL1, is nucleoid associated. We report that M. tuberculosis GroEL1 binds DNA with low specificity ...
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