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- Battistoni, Maria, et al. Show all 7 Authors
- Food and chemical toxicology 2020 v.140 pp. 111303
- abnormal development; active sites; additive effect; adverse outcome pathways; azoles; catalytic activity; computer simulation; computer software; congenital abnormalities; fungicides; gene expression; histone deacetylase; in vitro studies; metabolism; retinoic acid; teratogenicity; valproic acid
- ... Mixtures of substances sharing the same molecular initiating event (MIE) are supposed to induce additive effects. The proposed MIE for azole fungicides is CYP26 inhibition with retinoic acid (RA) local increase, triggering key events leading to craniofacial defects. Valproic acid (VPA) is supposed to imbalance RA-regulated gene expression trough histone deacetylases (HDACs) inhibition. The aim was ...
- Battistoni, Maria, et al. Show all 5 Authors
- Food and chemical toxicology 2019 v.123 pp. 553-560
- abnormal development; adverse outcome pathways; antifungal agents; computer software; cyproconazole; embryo (animal); embryo culture; flusilazole; hazard characterization; morphogenesis; prochloraz; rats; retinoic acid; triadimefon
- ... Facial malformations represent one of the most frequent abnormality in humans. The adverse outcome pathway involved in facial defects seems to be related to retinoic acid (RA) pathway imbalance. Environmental agents inducing craniofacial malformations in experimental models include pesticides (especially azole fungicides). By using the in vitro alternative method postimplantation rat whole embryo ...