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- Belavek, Kayla J., et al. Show all 8 Authors
- Journal of organic chemistry 2018 v.84 no.2 pp. 1035-1041
- Helianthus annuus; chemical structure; cysteine; hydrolysis; macrocyclization reactions; organic chemistry; peptides; trypsin inhibitors; urea
- ... We establish herein conditions for the cyclization of unprotected N-acyl urea-linked peptides to form macrocyclic peptides mediated by N-terminal cysteine. We report a detailed investigation of the parameters of the reaction, including variation of the reaction conditions, the C-terminal residue, and the macrocycle size. C-Terminal epimerization was not observed. The synthesis of macrocyclic targe ...