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You searched for: Author "Benjamin M. Brainard" Remove constraint Author: "Benjamin M. Brainard"
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1. Platelet number and function in response to a single intravenous dose of vincristine

Author:
Benjamin M. Brainard,   et al.   ; Erin C. Allen; Jaime L. Tarigo; Dana N. LeVine; Jamie P. Barber;     Show all 5 Authors
Source:
Journal of veterinary internal medicine 2021 v.35 no.4 pp. 1754-1762
ISSN:
0891-6640
Subject:
blood platelet count; flow cytometry; intravenous injection; thiazoles; thrombin; veterinary medicine; vincristine
Abstract:
... BACKGROUND: Vincristine might increase circulating platelet numbers but the functional capacity of these newly released platelets is unknown. OBJECTIVE: To evaluate and compare the functionality of mature and immature (reticulated) platelets after a single intravenous dose of vincristine in dogs. ANIMALS: Ten healthy purpose‐bred dogs. METHODS: Dogs prospectively received a single IV injection of ...
DOI:
10.1111/jvim.16169

2. Evaluation of the i-STAT Alinity v in a veterinary clinical setting

Author:
Benjamin M. Brainard,   et al.   ; Jasper E. Burke; Thuy Hien T. Nguyen; Tanya Davis; Amie Koenig; Selena L. Lane; Jennifer Good;     Show all 7 Authors
Source:
Journal of veterinary diagnostic investigation 2021 v.33 no.4 pp. 703-710
ISSN:
1943-4936
Subject:
blood; chemical species; point-of-care systems
Abstract:
... Many point-of-care (POC) analyzers are available for the measurement of electrolytes and acid-base status in animals. We assessed the precision of the i-STAT Alinity v, a recently introduced POC analyzer, and compared it to 2 commonly used and previously validated POC analyzers (i-STAT 1, Stat Profile pHOx Ultra). Precision was evaluated by performing multiple analyses of whole blood samples from ...
DOI:
10.1177/10406387211019710

3. Novel diagnostic and therapeutic approaches to elephant endotheliotropic herpesvirus 1a hemorrhagic disease in a captive juvenile asian elephant (elephas maximus)

Author:
Benjamin M. Brainard,   et al.   ; Maya L. Iyer; Christine M. Molter; Joseph P. Flanagan; Kendra L. Bauer; Rob Bernardy; Daryl Hoffman; Lily Parkinson; Tierra Smiley Evans; Taylor Pursell; Paul D. Ling;     Show all 11 Authors
Source:
Journal of zoo and wildlife medicine 2022 v.53 no.1 pp. 232-240
ISSN:
1937-2825
Subject:
Elephantid betaherpesvirus 1; Elephas maximus; adults; antibodies; coagulation; drugs; hemostasis; immunologic techniques; juveniles; medicine; plasminogen; seroconversion; therapeutics; viremia; wildlife; zoos
Abstract:
... Novel diagnostic and therapeutic methods were utilized in the successful management of severe elephant endotheliotropic herpesvirus hemorrhagic disease (EEHV-HD) in a 1.9-yr-old captive Asian elephant (Elephas maximus). High levels of EEHV1A viremia were detected for 12 d. In addition to established EEHV treatments, therapies included famciclovir-fortified elephant whole blood and plasma, mesenchy ...
DOI:
10.1638/2021-0096

4. 2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 1‐ Defining populations at risk

Author:
Benjamin M Brainard,   et al.   ; Armelle deLaforcade; Lenore Bacek; Marie‐Claude Blais; Corrin Boyd; Daniel L. Chan; Stefano Cortellini; Robert Goggs; Guillaume L Hoareau; Amy Koenigshof; Ron Li; Alex Lynch; Alan Ralph; Elizabeth Rozanski; Claire R Sharp;     Show all 15 Authors
Source:
Journal of veterinary emergency and critical care 2022 v.32 no.3 pp. 289-314
ISSN:
1479-3261
Subject:
digestive system diseases; guidelines; heartworms; hemolytic anemia; hyperadrenocorticism; kidney diseases; liver diseases; patients; risk; surveys; thrombosis
Abstract:
... OBJECTIVES: To expand the number of conditions and interventions explored for their associations with thrombosis in the veterinary literature and to provide the basis for prescribing recommendations. DESIGN: A population exposure comparison outcome format was used to represent patient, exposure, comparison, and outcome. Population Exposure Comparison Outcome questions were distributed to worksheet ...
DOI:
10.1111/vec.13204

5. Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE): Domain 5—Discontinuation of anticoagulant therapy in small animals

Author:
Benjamin M. Brainard,   et al.   ; Yekaterina Buriko; Jennifer Good; Alan G. Ralph; Elizabeth A. Rozanski;     Show all 5 Authors
Source:
Journal of veterinary emergency and critical care 2019 v.29 no.1 pp. 88-97
ISSN:
1479-3261
Subject:
animals; anticoagulants; databases; decision making; drug therapy; heparin; patients; risk; risk assessment; surgery; surveys; thrombosis
Abstract:
... OBJECTIVES: To systematically evaluate the evidence supporting the timing and mechanisms of permanent or temporary discontinuation of antiplatelet or anticoagulant medications in small animals DESIGN: Standardized, systematic evaluation of the literature, categorization of relevant articles according to level of evidence and quality (poor, fair, or good), and development of consensus on conclusion ...
DOI:
10.1111/vec.12796

6. American College of Veterinary Emergency and Critical Care (ACVECC) Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE) guidelines: Small animal

Author:
Benjamin M. Brainard,   et al.   ; Robert Goggs; Marie‐Claude Blais; Daniel L. Chan; Armelle M. deLaforcade; Elizabeth Rozanski; Claire R. Sharp;     Show all 7 Authors
Source:
Journal of veterinary emergency and critical care 2019 v.29 no.1 pp. 12-36
ISSN:
1479-3261
Subject:
animals; at-risk population; monitoring; risk; surveys; therapeutics; thrombosis; veterinary medicine
Abstract:
... OBJECTIVES: To systematically review available evidence and establish guidelines related to the risk of developing thrombosis and the management of small animals with antithrombotics. DESIGN: Standardized, systematic evaluation of the literature (identified by searching Medline via PubMed and CAB abstracts) was carried out in 5 domains (Defining populations at risk; Defining rational therapeutic u ...
DOI:
10.1111/vec.12801

7. Clinical application of the American College of Veterinary Emergency and Critical Care (ACVECC) Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE) guidelines to small animal cases

Author:
Benjamin M. Brainard,   et al.   ; Claire R. Sharp; Robert Goggs; Marie‐Claude Blais; Daniel L. Chan; Armelle M. deLaforcade; Elizabeth Rozanski;     Show all 7 Authors
Source:
Journal of veterinary emergency and critical care 2019 v.29 no.2 pp. 121-131
ISSN:
1479-3261
Subject:
cats; diagnostic techniques; dogs; drugs; hemodynamics; inflammation; monitoring; prognosis; risk factors; signs and symptoms (animals and humans); therapeutics; thrombosis
Abstract:
... OBJECTIVE: To illustrate the application of the Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE) guidelines to the management of dogs and cats at risk of developing thrombosis using a case‐based approach. ETIOLOGY: Dogs and cats become at risk of developing thrombosis from a wide range of conditions. These conditions often involve a specific insult followed b ...
DOI:
10.1111/vec.12804

8. Agreement among anesthesiologists regarding postoperative pain assessment in dogs

Author:
Benjamin M. Brainard,   et al.   ; Erik H. Hofmeister; Michele Barletta; Molly Shepard; Cynthia M. Trim; Jane Quandt;     Show all 6 Authors
Source:
Veterinary anaesthesia and analgesia 2018 v.45 no.5 pp. 695-702
ISSN:
1467-2987
Subject:
cameras; dogs; models; pain; pain assessment; posture; vocalization
Abstract:
... To establish evidence for the validity and reliability of three commonly used pain scales in dogs when assessed by video by specialists in anesthesia.Mixed-method test–retest observational study.A group of six American College of Veterinary Anesthesia and Analgesia board-certified specialists and 31 postoperative dogs.The evaluators scored 31 dogs using a visual analogue scale (VAS), numeric ratin ...
DOI:
10.1016/j.vaa.2018.04.001

9. Point of Care Assessment of Coagulation

Author:
Benjamin M. Brainard,   et al.   ; Clare E. Hyatt;     Show all 2 Author
Source:
Topics in companion animal medicine 2016 v.31 no.1 pp. 11-17
ISSN:
1938-9736
Subject:
adhesion; blood platelets; cell adhesion; coagulation; drugs; fibrinolysis; hemostasis; medicine; patients; pets; prothrombin; therapeutics; thromboplastin; veterinary medicine; viscoelasticity
Abstract:
... Disorders of hemostasis can be difficult to fully elucidate but can severely affect patient outcome. The optimal therapy for coagulopathies is also not always clear. Point of care (POC) testing in veterinary medicine can assist in the diagnosis of hemostatic disorders and also direct treatment. Advantages of POC testing include rapid turnaround times, ease of use, and proximity to the patient. Dis ...
DOI:
10.1053/j.tcam.2016.05.002

10. Retrospective evaluation of the effect of red blood cell product age on occurrence of acute transfusion‐related complications in dogs: 210 cases (2010–2012)

Author:
Benjamin M. Brainard,   et al.   ; Christina H. Maglaras; Amie Koenig; Deanna L. Bedard;     Show all 4 Authors
Source:
Journal of veterinary emergency and critical care 2017 v.27 no.1 pp. 108-120
ISSN:
1479-3261
Subject:
anemia; clinical trials; confidence interval; data analysis; distress; dogs; erythrocytes; fever; gastrointestinal system; hematologic tests; hemolysis; hospitals; medical records; mortality; odds ratio; patients; retrospective studies; risk factors; storage time
Abstract:
... OBJECTIVE: To determine whether red blood cell (RBC) product age influences the occurrence of acute transfusion‐related complications and mortality in dogs. The hypothesis was that acute transfusion‐related complications and mortality would increase with age of product. DESIGN: Retrospective study (2010–2012). SETTING: University teaching hospital. ANIMALS: Two hundred and ten clinical canine pati ...
DOI:
10.1111/vec.12530

11. Cardiogenic embolism in the cat

Author:
Benjamin M. Brainard,   et al.   ; Daniel F. Hogan;     Show all 2 Author
Source:
Journal of veterinary cardiology 2015 v.17 pp. S202
ISSN:
1760-2734
Subject:
cats; death; drugs; embolism; heart diseases; humans; pharmaceutical industry; risk
Abstract:
... Cardiogenic embolism (CE) in the cat, which has also been referred to as arterial thromboembolism, feline arterial thromboembolism, and saddle thrombus has been identified clinically in cats for decades and is an important clinical development and cause of death in cats with underlying heart disease. While a better understanding of this condition has been developed over the decades it is extremely ...
DOI:
10.1016/j.jvc.2015.10.006

12. Reliability of video recordings to evaluate quality of anesthesia recovery in dogs

Author:
Benjamin M. Brainard,   et al.   ; Jennifer E. Copeland; Erik H. Hofmeister; Jane E. Quandt;     Show all 4 Authors
Source:
Veterinary anaesthesia and analgesia 2017 v.44 no.3 pp. 409-416
ISSN:
1467-2987
Subject:
anesthesia; dogs; monitoring
Abstract:
... To assess the reliability of using video recordings to evaluate anesthesia recovery in dogs.Prospective study.A total of 30 dogs undergoing surgery.Recovery monitoring and video recording lasted from extubation until 1 hour later. Scoring was done in real time at the end of the hour by a graduate student using three systems: a simple descriptive scale, visual analog scale and numeric rating scale. ...
DOI:
10.1016/j.vaa.2016.03.009

13. Pharmacokinetics of tranexamic acid in healthy dogs and assessment of its antifibrinolytic properties in canine blood

Author:
Benjamin M. Brainard,   et al.   ; Katie E. Osekavage; Selena L. Lane; Mohammed Almoslem; Robert D. Arnold; Amie Koenig;     Show all 6 Authors
Source:
American journal of veterinary research 2018 v.79 no.10 pp. 1057-1063
ISSN:
0002-9645
Subject:
adults; blood; blood sampling; dogs; dose response; drugs; fibrinolysis; intravenous injection; models; pharmacodynamics; pharmacokinetics; veterinary medicine
Abstract:
... OBJECTIVE To assess pharmacokinetics of tranexamic acid (TXA) in dogs and assess antifibrinolytic properties of TXA in canine blood by use of a thromboelastography-based in vitro model of hyperfibrinolysis. ANIMALS 6 healthy adult dogs. PROCEDURES Dogs received each of 4 TXA treatments (10 mg/kg, IV; 20 mg/kg, IV; approx 15 mg/kg, PO; and approx 20 mg/kg, PO) in a randomized crossover-design study ...
DOI:
10.2460/ajvr.79.10.1057

14. Efficacy of a topical bovine-derived thrombin solution as a hemostatic agent in a rodent model of hepatic injury

Author:
Benjamin M. Brainard,   et al.   ; Desiree D. Rosselli; Chad W. Schmiedt;     Show all 3 Authors
Source:
Canadian journal of veterinary research 2015 v.79 no.4 pp. 303-308
ISSN:
0830-9000
Subject:
anesthesia; animal models; blood pressure; heart rate; hematocrit; hemorrhage; hemostasis; intravenous injection; liver; patients; rats; surgery; thrombin; topical application
Abstract:
... Hemorrhage is a major concern in patients undergoing hepatic surgery or in those with hepatic trauma. In these cases, employing traditional hemostatic strategies can be problematic due to the diffuse nature of hepatic hemorrhage and limited opportunities for direct hemostasis. This study assessed the efficacy of a bovine-derived thrombin solution, (BT), as a topical liquid agent to augment hemosta ...

15. Formulation and validation of a predictive model to correct blood glucose concentrations obtained with a veterinary point-of-care glucometer in hemodiluted and hemoconcentrated canine blood samples

Author:
Benjamin M. Brainard,   et al.   ; Selena L. Lane; Amie Koenig;     Show all 3 Authors
Source:
Journal of the American Veterinary Medical Association 2015 v.246 no.3 pp. 307-312
ISSN:
0003-1488
Subject:
blood glucose; dogs; erythrocytes; glucose; models; patients; prospective studies
Abstract:
... Objective-To determine the effect of PCV on veterinary point-of-care (POC) glucometer measurements in canine blood samples and develop a formula to correct the glucose concentration as measured by a point-of-care glucometer (POCgluc) given a known PCV. Design-Experimental and prospective study. Samples-Blood samples from 6 healthy dogs and from 30 hospitalized dogs. Procedures-60 mL of heparinized ...
DOI:
10.2460/javma.246.3.307

16. Effect of aminocaproic acid on clot strength and clot lysis of canine blood determined by use of an in vitro model of hyperfibrinolysis

Author:
Benjamin M. Brainard,   et al.   ; Jamie C. Brown; Daniel J. Fletcher; Ben Nie; Robert D. Arnold; Chad W. Schmiedt;     Show all 6 Authors
Source:
American journal of veterinary research 2016 v.77 no.11 pp. 1258-1265
ISSN:
0002-9645
Subject:
adults; adverse effects; blood; blood sampling; dogs; dose response; fibrinolysis; liquid chromatography; mass spectrometry; models; oral administration; pharmacokinetics
Abstract:
... OBJECTIVE To determine pharmacodynamic and pharmacokinetic profiles of aminocaproic acid (ACA) by use of a thromboelastography (TEG)-based in vitro model of hyperfibrinolysis and high-performance liquid chromatography–mass spectrometry. ANIMALS 5 healthy adult dogs. PROCEDURES A single dose of injectable ACA (20, 50, or 100 mg/kg) or an ACA tablet (approximately 100 mg/kg) was administered orally. ...
DOI:
10.2460/ajvr.77.11.1258

17. Anesthetic complications in dogs undergoing hepatic surgery: cholecystectomy versus non-cholecystectomy

Author:
Benjamin M Brainard,   et al.   ; Brigid R Burns; Erik H Hofmeister;     Show all 3 Authors
Source:
Veterinary anaesthesia and analgesia 2014 v.41 no.2 pp. 186-190
ISSN:
1467-2987
Subject:
anesthesia; anesthetics; blood pressure; cohort studies; dogs; hypotension; hypothermia; laparotomy; patients; survival rate
Abstract:
... To determine if dogs that undergo laparotomy for cholecystectomy suffer from a greater number or magnitude of perianesthetic complications, including hypotension, hypothermia, longer recovery time, and lower survival rate, than dogs that undergo laparotomy for hepatic surgery without cholecystectomy.Retrospective cohort study.One hundred and three dogs, anesthetised between January 2007 and Octobe ...
DOI:
10.1111/vaa.12100
PubMed:
24256129

18. Platelet parameters from an automated hematology analyzer in dogs with inflammatory clinical diseases

Author:
Benjamin M. Brainard,   et al.   ; Jo R. Smith; Katherine F. Smith;     Show all 3 Authors
Source:
veterinary journal 2014 v.201 no.3 pp. 406-411
ISSN:
1090-0233
Subject:
algorithms; blood; dog diseases; dogs; endotoxemia; hemangiosarcoma; hematology; hemolytic anemia; hyperadrenocorticism; inflammation; models; orthopedics; pancreatitis; platelet activation; refractive index; sepsis (infection); thrombocytopenia
Abstract:
... The mean platelet component (MPC) is a proprietary algorithm of an automated laser-based hematology analyzer system which measures the refractive index of platelets. The MPC is related linearly to platelet density and is an indirect index of platelet activation status. Previous investigations of canine inflammatory conditions and models of endotoxemia demonstrated a significant decrease in the MPC ...
DOI:
10.1016/j.tvjl.2014.07.009

19. Assessment of the relationships among coagulopathy, hyperfibrinolysis, plasma lactate, and protein C in dogs with spontaneous hemoperitoneum

Author:
Benjamin M. Brainard,   et al.   ; Daniel J. Fletcher; Elizabeth A. Rozanski; Armelle M. Laforcade; Marjory B. Brooks;     Show all 5 Authors
Source:
Journal of veterinary emergency and critical care 2016 v.26 no.1 pp. 41-51
ISSN:
1479-3261
Subject:
anticoagulants; blood sampling; case-control studies; coagulation; dogs; erythrocytes; fibrinogen; fibrinolysis; prothrombin; t-plasminogen activator; thromboplastin
Abstract:
... OBJECTIVE: To relate coagulation and fibrinolysis derangements to shock severity as reflected by plasma lactate concentrations in dogs with spontaneous hemoperitoneum (SHP) and determine the impact on transfusions. DESIGN: Prospective, observational, case‐control study. SETTING: Three veterinary teaching hospitals. ANIMALS: Twenty‐eight client‐owned dogs with SHP and 28 breed‐ and age‐matched cont ...
DOI:
10.1111/vec.12346

20. Update on Disseminated Intravascular Coagulation: When to Consider It, When to Expect It, When to Treat It

Author:
Benjamin M. Brainard,   et al.   ; Alan G. Ralph;     Show all 2 Author
Source:
Topics in companion animal medicine 2012 v.27 no.2 pp. 65-72
ISSN:
1938-9736
Subject:
anticoagulants; blood platelet count; disseminated intravascular coagulation; inflammation; medicine; patients; pets; phenotype; phenotypic variation; therapeutics; thrombin; thromboplastin; veterinary medicine
Abstract:
... Disseminated intravascular coagulation (DIC) spans a continuum in which clinical signs can range from a prothrombotic to a hemorrhagic phenotype, with some patients suffering from both concurrently. DIC is always caused by an underlying condition, with most cases linked to systemic inflammation or infection. Numerous factors contribute to the development of DIC, including aberrations in endothelia ...
DOI:
10.1053/j.tcam.2012.06.004