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- Author:
- Binesh Unnikrishnan, et al. ; Han-Wei Chu; Amit Nain; Scott G. Harroun; Huan-Tsung Chang; Chih-Ching Huang; Show all 6 Authors
- Source:
- Biosensors & bioelectronics 2022 v.216 pp. 114615
- ISSN:
- 0956-5663
- Subject:
- alloys; bioassays; biosensors; desorption; enzyme activity; fibrin; fibrinogen; humans; irradiation; mass spectrometry; models; nanogold; silver; thrombin
- Abstract:
- ... Pulsed laser irradiation can cause the fragmentation of nanoparticles, which generates cluster ions. This allows nanoparticles to be adopted as mass tag/signal amplifiers in laser desorption/ionization mass spectrometry (LDI-MS) bioassays. Herein, we demonstrate the potential of using the signal from alloy cluster ions in bioassays through a fibrin clot model to determine the activity of thrombin. ...
- DOI:
- 10.1016/j.bios.2022.114615
- https://doi.org/10.1016/j.bios.2022.114615
- Author:
- Binesh Unnikrishnan, et al. ; Ju-Yi Mao; Dragan Miscevic; Han-Wei Chu; C. Perry Chou; Lung Chang; Han-Jia Lin; Chih-Ching Huang; Show all 8 Authors
- Source:
- Journal of colloid and interface science 2022 v.608 pp. 1813-1826
- ISSN:
- 0021-9797
- Subject:
- Escherichia coli; acclimation; antibacterial properties; biocompatibility; carbon; carbonization; chlorhexidine; cupric oxide; evolution; gentamicin; graphene oxide; lysine; membrane potential; minimum inhibitory concentration; multiple drug resistance; nanogels; nanosilver; polymerization; pyrolysis; reactive oxygen species; silver; zinc oxide
- Abstract:
- ... Developing antimicrobial agents that can eradicate drug-resistant (DR) bacteria and provide sustained protection from DR bacteria is a major challenge. Herein, we report a mild pyrolysis approach to prepare carbon nanogels (CNGs) through polymerization and the partial carbonization of l-lysine hydrochloride at 270 °C as a potential broad-spectrum antimicrobial agent that can inhibit biopolymer-pro ...
- DOI:
- 10.1016/j.jcis.2021.10.107
- https://doi.org/10.1016/j.jcis.2021.10.107
- Author:
- Binesh Unnikrishnan, et al. ; Chin-Jung Lin; Caitlin W. Lehman; Pei-Hua Wang; Yufeng Jane Tseng; Scott G. Harroun; Shih-Chao Lin; Chih-Ching Huang; Show all 8 Authors
- Source:
- Carbon 2022 v.192 pp. 285-294
- ISSN:
- 0008-6223
- Subject:
- Enterovirus A; antioxidants; antiviral agents; antiviral properties; carbon; cytotoxicity; death; guaiacol; hesperetin; hesperidin; hydrophobicity; median effective concentration; oxidative stress; polymers; pyrolysis; therapeutics; virus replication
- Abstract:
- ... In recent years, numerous reports have revealed that hesperetin (Hsp) and its glycoside form, hesperidin (Hsd), exhibit significant antioxidant, anti-inflammatory, antibacterial, and antiviral activities. However, high concentrations of Hsp or Hsd are required to achieve in vivo therapeutic efficacy, since the accompanying toxicity has limited their use practical applications. To enhance bioactivi ...
- DOI:
- 10.1016/j.carbon.2022.03.009
- https://doi.org/10.1016/j.carbon.2022.03.009
- Author:
- Binesh Unnikrishnan, et al. ; Ren-Siang Wu; Yu-Syuan Lin; Amit Nain; Yu-Feng Lin; Cheng-Ruei Yang; Tzu-Heng Chen; Yu-Fen Huang; Chih-Ching Huang; Huan-Tsung Chang; Show all 10 Authors
- Source:
- Biosensors & bioelectronics 2022 v.211 pp. 114362
- ISSN:
- 0956-5663
- Subject:
- biocompatibility; biosensors; cell nucleolus; drug therapy; fluorescence; fluorescent dyes; hydrolysis; hydrophilicity; organelles; photoirradiation; pyrolysis; surfactants; ultraviolet radiation
- Abstract:
- ... Monitoring of structural changes in subcellular organelles is critical to evaluate the chemotherapeutic response of cells. However, commercial organelle selective fluorophores are easily photobleached, and thus are unsuitable for real-time and long-term observation. We have developed photostable carbon-dot liposomes (CDsomes)-based fluorophores for organellar and suborganellar imaging to circumven ...
- DOI:
- 10.1016/j.bios.2022.114362
- https://doi.org/10.1016/j.bios.2022.114362
- Author:
- Binesh Unnikrishnan, et al. ; Wei-Jan Lin; Yu-Syuan Lin; Huan-Tsung Chang; Chih-Ching Huang; Show all 5 Authors
- Source:
- Biosensors & bioelectronics 2021 v.194 pp. 113610
- ISSN:
- 0956-5663
- Subject:
- biosensors; blood glucose; cupric oxide; diabetes; electrochemistry; electrodes; foil; glucose; oxidation; oxygen; saliva
- Abstract:
- ... Highly electrocatalytic cuprous halide/copper oxide nanoparticles (CuX@CunO NPs; X = Cl, Br or I; n = 1 or 2) have been fabricated on copper foils for sensitive detection of glucose. Formation of CuX@CuₙO NPs involves two steps– in situ electrochemical deposition of CuX on the foil and then conversion of CuX to CuₙO. The deposited CuX converts to CuₙO, leading to the generation of abundant oxygen ...
- DOI:
- 10.1016/j.bios.2021.113610
- https://doi.org/10.1016/j.bios.2021.113610
- Author:
- Binesh Unnikrishnan, et al. ; Irma Suryani Gultom; Yu-Ting Tseng; Huan-Tsung Chang; Chih-Ching Huang; Show all 5 Authors
- Source:
- Journal of colloid and interface science 2021 v.598 pp. 260-273
- ISSN:
- 0021-9797
- Subject:
- Candida albicans; Escherichia coli; absorption; ambient temperature; angiogenesis; catechin; collagen; dyes; gold; keratinocytes; light intensity; methicillin-resistant Staphylococcus aureus; nanocomposites; photocatalysis; reactive oxygen species; titanium; titanium dioxide; xenon
- Abstract:
- ... We report a one-pot, room-temperature, morphology-controlled synthesis of titanium oxide (TiOₓ)–gold nanocomposites (TiOₓ–Au NCs) using HAuCl₄ and TiCl₃ as precursors, and catechin as reducing agent. TiOₓ–Au NCs have a range of morphologies from star-like to urchin-like shape depending on the concentration of TiCl₃ in the reaction mixture. The urchin-shaped TiOₓ–Au NCs exhibited excellent photocat ...
- DOI:
- 10.1016/j.jcis.2021.04.035
- https://doi.org/10.1016/j.jcis.2021.04.035
- Author:
- Binesh Unnikrishnan, et al. ; Anisha Anand; Ju-Yi Mao; Chin-Jung Lin; Jui-Yang Lai; Chih-Ching Huang; Show all 6 Authors
- Source:
- Water research 2022 v.212 pp. 118121
- ISSN:
- 0043-1354
- Subject:
- Escherichia coli; Infectious bronchitis virus; antioxidants; asymmetric membranes; bacteria; energy use and consumption; filtration; graphene oxide; keratitis; nanocomposites; nanogels; research; tap water; water; water pollution
- Abstract:
- ... Carbon-based materials, especially graphene oxide (GO) and carbon dots possessing antibacterial properties, are widely used for various applications. Recently, we reported the antibacterial and antioxidant properties of carbonized nanogels (CNGs) for the treatment of bacterial keratitis, and as a virostatic agent against infectious bronchitis virus. In this work, we demonstrate the use of CNGs/GO ...
- DOI:
- 10.1016/j.watres.2022.118121
- https://doi.org/10.1016/j.watres.2022.118121
- Author:
- Binesh Unnikrishnan, et al. ; Chia-Wen Lien; Han-Wei Chu; Chih-Ching Huang; Show all 4 Authors
- Source:
- Journal of hazardous materials 2021 v.401 pp. 123397
- ISSN:
- 0304-3894
- Subject:
- catalytic activity; groundwater; heavy metals; pollution; rapid methods; spectrophotometers; toxicity; ultraviolet-visible spectroscopy; water table
- Abstract:
- ... Large scale mining, manufacturing industries, exploitation of underground water, depletion of groundwater level, and uncontrolled discharge of industrial wastes have caused severe heavy metal ion pollution to the environment throughout the world. Therefore, the rapid detection of such toxic metal ions is inevitable. However, conventional methods require sophisticated instruments and skilled manpow ...
- DOI:
- 10.1016/j.jhazmat.2020.123397
- https://doi.org/10.1016/j.jhazmat.2020.123397
- Author:
- Binesh Unnikrishnan, et al. ; Chien-Wei Wu; Arumugam Sangili; Ya-Ju Hsu; Yu-Ting Tseng; Jyoti Shanker Pandey; Huan-Tsung Chang; Chih-Ching Huang; Show all 8 Authors
- Source:
- Journal of colloid and interface science 2022 v.628 pp. 849-857
- ISSN:
- 0021-9797
- Subject:
- aluminum; fluorine; hot water treatment; hydrofluoric acid; hydrogen production; mass transfer; microwave treatment; molybdenum; oxidation; oxygen; sodium; sulfur
- Abstract:
- ... Synthesizing MXenes from Mₙ₊₁AXₙ (MAX) phases using hazardous hydrogen fluoride is a common and effective method. However, fluorine termination on the basal planes and edges of the resulting MXenes is undesirable for the electrocatalytic hydrogen evolution reaction (HER), while oxygen (O), hydroxyl (OH), and sulfur (S) termination favors this reaction. Herein, we unveil a simple fluorine-free exfo ...
- DOI:
- 10.1016/j.jcis.2022.07.176
- https://doi.org/10.1016/j.jcis.2022.07.176
- Author:
- Binesh Unnikrishnan, et al. ; Ju-Yi Mao; Han-Wei Chu; Scott G. Harroun; Yet-Ran Chen; An-Tai Wu; Huan-Tsung Chang; Han-Jia Lin; Chih-Ching Huang; Show all 9 Authors
- Source:
- Biomaterials science 2021 v.9 no.13 pp. 4679-4690
- ISSN:
- 2047-4849
- Subject:
- alginates; animal models; anticoagulant activity; anticoagulants; biocompatibility; biocompatible materials; blood; caffeic acid; carbonization; catechin; coagulation; dissociation; ferulic acid; fucoidan; nanogels; nanosheets; naringenin; quercetin; thrombin
- Abstract:
- ... We have demonstrated that alginate with negligible anticoagulant activity can be converted into carbonized nanogels with potent anticoagulant activity through a solid-state heating process. The conversion of alginate into graphene-like nanosheet (GNS)-embedded polyphenolic-alginate nanogels (GNS/Alg-NGs) has been carried out through condensation and carbonization processes. The GNS/Alg-NGs exhibit ...
- DOI:
- 10.1039/d1bm00402f
- https://doi.org/10.1039/d1bm00402f
- Author:
- Binesh Unnikrishnan, et al. ; Chien-Wei Wu; Yu-Ting Tseng; Shih-Chun Wei; Huan-Tsung Chang; Chih-Ching Huang; Show all 6 Authors
- Source:
- Journal of colloid and interface science 2019 v.541 pp. 75-85
- ISSN:
- 0021-9797
- Subject:
- ammonium; annealing; catalytic activity; citrates; detection limit; dissolved oxygen; enzyme activity; ferrimagnetic materials; fluorescence; fructose; glucose; honey; hydrogen peroxide; iron; ketoses; manganese; manganese oxides; mannose; nanomaterials; oxidation; porous media; potassium permanganate; sucrose; synthesis
- Abstract:
- ... Nanomaterials possessing enzyme-like activity have been extensively studied owing to their high stability and tunable catalytic properties. In this work, a simple method has been developed for the synthesis of porous manganese oxide/manganese ferrite (MnOx/MnFe2O4) nanopopcorns (MFNPs) in neutral media. The MFNPs exhibit dual enzymatic activities towards selective oxidation of ketoses followed by ...
- DOI:
- 10.1016/j.jcis.2019.01.061
- https://doi.org/10.1016/j.jcis.2019.01.061
- Author:
- Binesh Unnikrishnan, et al. ; Chien-Wei Wu; Arun Prakash Periasamy; I-Wen Peter Chen; Yu-Ting Tseng; Ya-Yun Yang; Wei-Jan Lin; Chih-Ching Huang; Huan-Tsung Chang; Show all 9 Authors
- Source:
- ACS sustainable chemistry & engineering 2020 v.8 no.26 pp. 9794-9802
- ISSN:
- 2168-0485
- Subject:
- cation exchange; cost effectiveness; electrochemistry; foil; green chemistry; oxygen production; porosity; surface area; surface roughness; voltammetry
- Abstract:
- ... In this work, we demonstrate a simple electrochemical approach to convert copper foil into a cost-effective and stable cobalt-doped hollow-structured CuBr@CuO electrocatalyst with high surface porosity for oxygen evolution reaction (OER). First, a thin layer of surface copper atoms of the foil was converted to γ-CuBr nanocorals (NCs) by dissolution and in situ deposition in a bromide medium. Then, ...
- DOI:
- 10.1021/acssuschemeng.0c02309
- https://doi.org/10.1021/acssuschemeng.0c02309
13. Nanoparticle-based laser desorption/ionization mass spectrometric analysis of drugs and metabolites
- Author:
- Binesh Unnikrishnan, et al. ; Han-Wei Chu; Anisha Anand; Ju-Yi Mao; Chih-Ching Huang; Show all 5 Authors
- Source:
- Yàowù shípǐn fēnxī 2018 v.26 no.4 pp. 1215-1228
- ISSN:
- 1021-9498
- Subject:
- crystallization; desorption; disease diagnosis; drugs; forensic sciences; ionization; mass spectrometry; metabolites; nanocomposites; nanoparticles; surface area
- Abstract:
- ... Nanoparticle-assisted laser desorption/ionization mass spectrometry (LDI-MS) is a powerful tool for the analysis of a wide range of molecules. Many of the drawbacks in the matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) can be avoided with the application of nanomaterials as matrices as well as substrates for the LDI-MS to achieve a low background noise in low m/z region a ...
- DOI:
- 10.1016/j.jfda.2018.07.001
- https://doi.org/10.1016/j.jfda.2018.07.001
- Author:
- Binesh Unnikrishnan, et al. ; Chia-Wen Lien; Scott G. Harroun; Chih-Min Wang; Jia-Yaw Chang; Huan-Tsung Chang; Chih-Ching Huang; Show all 7 Authors
- Source:
- Biosensors & bioelectronics 2018 v.102 pp. 510-517
- ISSN:
- 0956-5663
- Subject:
- ambient temperature; biosensors; blood sampling; catalytic activity; cobalt; color; cost effectiveness; cyanides; enzyme activity; fluorescence; glucose; glucose oxidase; graphene oxide; hydrogen peroxide; ions; nanohybrids; nylon; oxidation; wastewater
- Abstract:
- ... In this paper, we report a simple one-step synthesis of well-dispersed amorphous cobalt hydroxide/oxide-modified graphene oxide (CoOxH-GO) possessing peroxidase-like catalytic activity, and its application for the detection of H2O2, glucose, and CN– ions. CoOxH is formed and deposited in situ on the GO surface through the reaction between GO (size ~ 240nm) and Co²⁺ in basic solution at room temper ...
- DOI:
- 10.1016/j.bios.2017.11.063
- https://doi.org/10.1016/j.bios.2017.11.063
- Author:
- Binesh Unnikrishnan, et al. ; Pei-Xin Lai; Ju-Yi Mao; Han-Wei Chu; Chien-Wei Wu; Huan-Tsung Chang; Chih-Ching Huang; Show all 7 Authors
- Source:
- Biomaterials science 2018 v.6 no.7 pp. 1882-1891
- ISSN:
- 2047-4849
- Subject:
- DNA; anticoagulants; binding capacity; biocompatibility; biotechnology; coagulation; cost effectiveness; cytotoxicity; dissociation; fibrin; fibrinogen; graphene oxide; hemolysis; hemorrhage; hemostasis; heparin; hydrogen bonding; hydrophobic bonding; nanocomposites; oligonucleotides; prothrombin; thrombin; thromboplastin; warfarin
- Abstract:
- ... Graphene oxide (GO) has unique structural properties, can effectively adsorb single-strand DNA through π–π stacking, hydrogen bonding and hydrophobic interactions, and is useful in many biotechnology applications. In this study, we developed a thrombin-binding-aptamers (15- and 29-mer) conjugated graphene oxide (TBA₁₅/TBA₂₉–GO) composite for the efficient inhibition of thrombin activity towards th ...
- DOI:
- 10.1039/c8bm00288f
- https://doi.org/10.1039/c8bm00288f
- Author:
- Binesh Unnikrishnan, et al. ; Chia-Yin Chang; Han-Wei Chu; Anisha Anand; Chih-Ching Huang; Show all 5 Authors
- Source:
- Analytical methods 2016 v.8 no.46 pp. 8123-8133
- ISSN:
- 1759-9679
- Subject:
- chemical species; desorption; energy; gold; heat transfer; ionization; ions; ligands; mass spectrometry; monitoring; nanogold
- Abstract:
- ... Laser desorption/ionization (LDI) coupled with mass spectrometry (MS) has evolved as an important tool for the analysis of a wide range of analytes, from small molecules to biomacromolecules. The LDI-MS technique requires a suitable matrix or substrate to absorb laser energy for the desorption and ionization of analytes. LDI-MS performed with an organic matrix easily suffers from many matrix effec ...
- DOI:
- 10.1039/c6ay02378a
- https://doi.org/10.1039/c6ay02378a
- Author:
- Binesh Unnikrishnan, et al. ; Selvakumar Palanisamy; Shen-Ming Chen; Show all 3 Authors
- Source:
- Biosensors & bioelectronics 2013 v.39 pp. 70-75
- ISSN:
- 0956-5663
- Subject:
- biocomposites; biosensors; catalytic activity; cost effectiveness; cross-linking reagents; electrochemistry; glassy carbon electrode; glucose; glucose oxidase; graphene; microbial fuel cells
- Abstract:
- ... We report a simple electrochemical approach for the immobilization of glucose oxidase (GOx) on reduced graphene oxide (RGO). The immobilization of GOx was achieved in a single step without any cross linking agents or modifiers. A simple solution phase approach was used to prepare exfoliated graphene oxide (GO), followed by electrochemical reduction to get RGO–GOx biocomposite. The direct electroch ...
- DOI:
- 10.1016/j.bios.2012.06.045
- https://doi.org/10.1016/j.bios.2012.06.045
- Author:
- Binesh Unnikrishnan, et al. ; Lung-Hsiang Peng; Chi-Yu Shih; Tung-Ming Hsiung; Jeng Chang; Pang-Hung Hsu; Tai-Chia Chiu; Chih-Ching Huang; Show all 8 Authors
- Source:
- Marine biotechnology 2016 v.18 no.2 pp. 283-292
- ISSN:
- 1436-2228
- Subject:
- Emiliania huxleyi; Isochrysis galbana; Nannochloris; Skeletonema; Tetraselmis chuii; Thalassiosira; absorption; cost effectiveness; desorption; heat; ionization; mass spectrometry; microalgae; microorganisms; nanomaterials
- Abstract:
- ... In this study, we demonstrate a simple method to identify microalgae by surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) using three different substrates: HgSe, HgTe, and HgTeSe nanostructures. The fragmentation/ionization processes of complex molecules in algae varied according to the heat absorption and transfer efficiency of the nanostructured matrices (NMs). Therefore, ...
- DOI:
- 10.1007/s10126-016-9685-9
- https://doi.org/10.1007/s10126-016-9685-9
- Author:
- Binesh Unnikrishnan, et al. ; Cheng-I Weng; Huan-Tsung Chang; Chia-Hua Lin; Yu-Wei Shen; Yu-Jia Li; Chih-Ching Huang; Show all 7 Authors
- Source:
- Biosensors & bioelectronics 2015 v.68 pp. 1-6
- ISSN:
- 0956-5663
- Subject:
- Escherichia coli K12; apple juice; biosensors; carbon; citrates; flagellum; fluorescence; humans; lectins; mannose; microbial detection; quantum dots; tap water; urine; wavelengths
- Abstract:
- ... In this study, we used a simple one-step dry heating method to synthesize mannose-modified fluorescent carbon quantum dots (Man-CQDs) from solid ammonium citrate and mannose, and successfully applied for labeling Escherichia coli. The highly soluble Man-CQDs had an average particle diameter of 3.1±1.2nm and exhibited a quantum yield of 9.8% at excitation and emission wavelengths of 365 and 450nm, ...
- DOI:
- 10.1016/j.bios.2014.12.028
- https://doi.org/10.1016/j.bios.2014.12.028
20. Graphene impregnated with horseradish peroxidase multimer for the determination of hydrogen peroxide
- Author:
- Binesh Unnikrishnan, et al. ; Yogeswaran Umasankar; Shen-Ming Chen; Tzu-Wei Ting; Show all 4 Authors
- Source:
- Analytical methods 2012 v.4 no.11 pp. 3653-3660
- ISSN:
- 1759-9679
- Subject:
- adsorption; algorithms; analytical methods; atomic force microscopy; catalytic activity; detection limit; electrochemistry; glassy carbon electrode; graphene; hydrogen peroxide; peroxidase; scanning electron microscopy; surface area
- Abstract:
- ... Horseradish peroxidase (HRP) multimer on a graphene modified glassy carbon electrode (GCE) has been fabricated by carbodiimide coupling reaction. The possible adsorption sites of HRP on graphene were predicted by Lamarckian genetic algorithm. It has been observed that HRP has five possible sites for its adsorption to graphene. Scanning electron microscopy and atomic force microscopy measurements s ...
- DOI:
- 10.1039/c2ay25276g
- https://doi.org/10.1039/c2ay25276g