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- Bloom, Samuel I., et al. Show all 10 Authors
- Journal of the American Chemical Society 2019 v.141 no.13 pp. 5169-5181
- cost effectiveness; enzyme activity; enzymes; ligands; proteins; screening
- ... DNA-encoded chemical libraries are increasingly used in pharmaceutical research because they enable the rapid discovery of synthetic protein ligands. Here we explored whether target-class focused DNA-encoded chemical libraries can be cost-effective tools to achieve robust screening productivity for a series of proteins. The study revealed that a DNA-encoded library designed for NAD⁺-binding pocket ...