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1. The contribution of the immune response to enhanced colibacillosis upon preceding viral respiratory infection in broiler chicken in a dual infection model

Author:
Bonhof, Josette,   et al.   ; Weerts, Erik A.W.S.; Matthijs, Mieke G.R.; van Haarlem, Daphne A.; Dwars, R. Marius; Gröne, Andrea; Verheije, M. Hélène; Jansen, Christine A.;     Show all 8 Authors
Source:
Veterinary immunology and immunopathology 2021 v.238 pp. 110276
ISSN:
0165-2427
Subject:
Avian metapneumovirus; Avian orthoavulavirus 1; Escherichia coli; Infectious bronchitis virus; air; bacterial antigens; body weight; broiler chickens; euthanasia; gene expression; immune response; immunohistochemistry; immunopathology; interleukin-10; interleukin-17; interleukin-6; lungs; macrophages; models; monocytes; pneumonia; tracheitis
Abstract:
... Colibacillosis in chickens caused by avian pathogenic Escherichia coli (APEC) is known to be aggravated by preceding infections with infectious bronchitis virus (IBV), Newcastle disease virus (NDV) and avian metapneumovirus (aMPV). The mechanism behind these virus-induced predispositions for secondary bacterial infections is poorly understood. Here we set out to investigate the immunopathogenesis ...
DOI:
10.1016/j.vetimm.2021.110276