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- Bottinger, Erwin P, et al. Show all 7 Authors
- TheAmerican journal of clinical nutrition 2019 v.110 no.1 pp. 16-23
- African Americans; European Americans; Hispanic Americans; Latinos; ancestry; at-risk population; body mass index; ecosystems; genetic background; lifestyle; men; obesity; women; Africa; Europe; North America; South America
- ... African Americans (AAs) and Hispanic/Latinos (HLs) have higher risk of obesity than European Americans, possibly due to differences in environment and lifestyle, but also reflecting differences in genetic background. To gain insight into factors contributing to BMI (in kg/m²) and obesity risk (BMI ≥ 30) among ancestry groups, we investigate the role of self-reported ancestry, proportion of genetic ...
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- Böttinger, Erwin P., et al. Show all 4 Authors
- Nucleic acids research 2006 v.34 pp. D586
- Internet; computer software; cytogenetics; databases; genes; genomics; humans; mice; nucleic acids; quantitative trait loci; rats
- ... Identifying genes that underlie quantitative trait loci (QTL) is a challenging task. Here, we present a new QTL software system, named QTL MatchMaker. The system is designed to integrate and mine QTL information across human, mouse and rat genomes and to annotate functional genomic data. It combines and organizes information from relevant public databases and publications and integrates QTL, physi ...
- Böttinger, Erwin P., et al. Show all 7 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2008 v.105 no.37 pp. 14106-14111
- mitochondrial membrane; metabolism; transmembrane proteins; oxidative stress; serine proteinases; reactive oxygen species; models; mitochondria; apoptosis; membrane potential
- ... Cellular localization determines whether the serine protease HtrA2 exerts pro- or antiapoptotic functions. In contrast to the well-characterized proapoptotic function of cytosolic HtrA2, mechanisms underlying the mitochondrial protective role are poorly understood. Mpv17l is a transmembrane protein previously implicated in peroxisomal reactive oxygen species metabolism and a close homolog of the i ...
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