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- Briggs, Kyle, et al. Show all 5 Authors
- Analytical chemistry 2019 v.91 no.19 pp. 12228-12237
- DNA; DNA fragmentation; chemical species; electrophoresis; geometry; models; nanopores; nucleotide sequences; proteins
- ... Using a solid-state nanopore to measure the concentration of clinically relevant target analytes, such as proteins or specific DNA sequences, is a major goal of nanopore research. This is usually achieved by measuring the capture rate of the target analyte through the pore. However, progress is hindered by sources of systematic error that are beyond the level of control currently achievable with s ...
- Briggs, Kyle, et al. Show all 7 Authors
- Electrophoresis 2015 v.36 no.15 pp. 1759-1767
- DNA; agarose; electrophoresis; gels; polyacrylamide
- ... We demonstrate the ability to slow DNA translocations through solid‐state nanopores by interfacing the trans side of the membrane with gel media. In this work, we focus on two reptation regimes: when the DNA molecule is flexible on the length scale of a gel pore, and when the DNA behaves as persistent segments in tight gel pores. The first regime is investigated using agarose gels, which produce a ...
- Briggs, Kyle, et al. Show all 9 Authors
- Analytical chemistry 2016 v.88 no.23 pp. 11900-11907
- algorithms; analytical methods; computer software; medicine; models; nanopores; single-stranded DNA
- ... Biological and solid-state nanometer-scale pores are the basis for numerous emerging analytical technologies for use in precision medicine. We developed Modular Single-Molecule Analysis Interface (MOSAIC), an open source analysis software that improves the accuracy and throughput of nanopore-based measurements. Two key algorithms are implemented: ADEPT, which uses a physical model of the nanopore ...
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