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- Brooks Crickard, J., et al. Show all 2 Author
- Methods 2019 v.159-160 pp. 70-81
- DNA; DNA-binding proteins; DNA-directed RNA polymerase; Saccharomyces cerevisiae; chromatin; eukaryotic cells; genes; messenger RNA; non-coding RNA; peptide elongation factors; transcription (genetics); transcriptional elongation factors
- ... Transcription of DNA into RNA is critical for all life, and RNA polymerases are enzymes tasked with this activity. In eukaryotes, RNA Polymerase II (RNAPII) is responsible for transcription of all protein coding genes and many non-coding RNAs. RNAPII carries out the remarkable feat of unwinding the stable double-stranded DNA template, synthesizing the transcript and re-forming the double helix beh ...