You searched for:
Keyword
"Bryan L. Stegelmeier"
Remove constraint Keyword: "Bryan L. Stegelmeier"
PubAg
Main content area
Limit your search
Search
29 Search Results
« Previous |
1 - 20 of 29
|
Next »
Search Results
- Author:
- Bryan L. Stegelmeier, et al. ; Dale R. Gardner; Kip E. Panter; Clinton A. Stonecipher; Show all 4 Authors
- Source:
- Journal of agricultural and food chemistry 2021 v.69 no.4 pp. 1251-1258
- ISSN:
- 1520-5118
- Subject:
- Salvia reflexa; alfalfa hay; cattle; death; diterpenoids; food chemistry; fractionation; hepatotoxicity; irrigation canals; mice; necrosis; oral administration
- Abstract:
- ... A case of baled alfalfa hay contaminated with multiple weeds induced hepatotoxicity and death in cattle. The hepatotoxic compounds were isolated by bioassay-guided fractionation using a mouse model and identified as salviarin, salvianduline D, rhyacophiline, and 7-hydroxyrhyacophiline. The structure of 7-hydroxyrhyacophiline has not been previously reported. All compounds were found to induce seve ...
- DOI:
- 10.1021/acs.jafc.0c06390
- https://doi.org/10.1021/acs.jafc.0c06390
- Author:
- Bryan L. Stegelmeier, et al. ; Kip E. Panter; Dale R. Gardner; Clinton A. Stonecipher; Stephen T. Lee; Don Kitchen; Adeline Brackett; Charlie Davis; Show all 8 Authors
- Source:
- Journal of veterinary diagnostic investigation 2021 v.33 no.3 pp. 538-547
- ISSN:
- 1943-4936
- Subject:
- Salvia reflexa; aggression; alfalfa hay; anorexia; beef cattle; blindness; cattle feeding; feed contamination; hepatotoxicity; histopathology; jaundice; liver diseases; mice; mixed breeds; necrosis; plant poisoning; poisonous plants
- Abstract:
- ... Salvia reflexa (lance-leaf sage)-contaminated alfalfa hay was fed to ~500 mixed-breed beef cattle. Within hours of exposure, nearly half of the cattle developed lethargy, anorexia, depression, and recumbency, followed by bellowing, colic, and death. Even though the uneaten contaminated hay was removed the first day, nearly 100 animals died within the first 48 h. Three of these cattle were examined ...
- Handle:
- 10113/7366851
- DOI:
- 10.1177/1040638721995784
- https://doi.org/10.1177/1040638721995784
- Author:
- Bryan L. Stegelmeier, et al. ; Benedict T. Green; Dale R. Gardner; Clint A. Stonecipher; Stephen T. Lee; James A. Pfister; Kevin D. Welch; Daniel Cook; T. Zane Davis; Show all 9 Authors
- Source:
- Rangelands 2020 v.42 no.1 pp. 1-8
- ISSN:
- 0190-0528
- Subject:
- Delphinium; administrative management; age; alkaloids; bulls; cattle breeds; chemistry; dosage; financial economics; heifers; pastures; poisoning; rangelands; steers; toxicity; yearlings
- Abstract:
- ... •Toxic larkspurs (Delphinium species) cause large economic losses from cattle deaths, increased management costs, and reduced utilization of pastures and rangelands.•Larkspur toxicity to cattle can vary by geographic location due to toxic alkaloid content.•Larkspur alkaloid chemistry can be used to predict plant toxicity.•Cattle breeds differ in their susceptibility to larkspur poisoning.•As cattl ...
- DOI:
- 10.1016/j.rala.2020.01.004
- https://doi.org/10.1016/j.rala.2020.01.004
- Author:
- Bryan L. Stegelmeier, et al. ; Steven M. Colegate; Edward L. Knoppel; Kerry A. Rood; Mark G. Collett; Show all 5 Authors
- Source:
- Toxicon 2019 v.167 pp. 60-66
- ISSN:
- 0041-0101
- Subject:
- Pastinaca sativa; animal feeding; bergapten; blood serum; dermatitis; goats; high performance liquid chromatography; horses; intravenous injection; methoxsalen; photosensitivity; poisonous plants; tandem mass spectrometry
- Abstract:
- ... Wild parsnip (Pastinaca sativa) has been associated with livestock and human photosensitization. An investigation of a natural occurrence of photosensitization of grazing horses identified wild parsnip as a possible cause. HPLC-MS and MS/MS analysis of this plant identified five furanocoumarins i.e., xanthotoxin, bergapten, isopimpinellin, imperatorin and a putative methoxyimperatorin. Goats fed t ...
- DOI:
- 10.1016/j.toxicon.2019.06.007
- https://doi.org/10.1016/j.toxicon.2019.06.007
- Author:
- Bryan L. Stegelmeier, et al. ; Louisiane de Carvalho Nunes; Daniel Cook; James A. Pfister; Dale R. Gardner; Franklin Riet-Correa; Kevin D. Welch; Show all 7 Authors
- Source:
- Toxicon 2019 v.171 pp. 20-28
- ISSN:
- 0041-0101
- Subject:
- Astragalus lentiginosus; Ipomoea carnea; Oxytropis; alfalfa; blood serum; body weight; enzyme activity; enzyme inhibitors; glycosidases; glycosides; goats; indolizidines; intestines; necropsy; poisoning; signs and symptoms (animals and humans); swainsonine; toxicity
- Abstract:
- ... The indolizidine alkaloid swainsonine, found in some Astragalus and Oxytropis (i.e., locoweed) species, is a potent cellular glycosidase inhibitor that often poisons livestock. Other toxic genera such as some Ipomoea species also contain swainsonine as well as calystegines which are similar polyhydroxy alkaloids. The toxicity of calystegines is poorly characterized; however, they are also potent g ...
- DOI:
- 10.1016/j.toxicon.2019.09.016
- https://doi.org/10.1016/j.toxicon.2019.09.016
- Author:
- Bryan L. Stegelmeier, et al. ; T. Zane Davis; Stephen T. Lee; Benedict T. Green; Carol G. Chitko-McKown; Show all 5 Authors
- Source:
- Research in veterinary science 2018 v.118 pp. 419-422
- ISSN:
- 0034-5288
- Subject:
- Ageratina altissima; ambient temperature; blood serum; body weight; creatine kinase; drying; exercise; goats; grinding; shelf life; storage temperature; storage time; toxicity; toxins; tremetone
- Abstract:
- ... White snakeroot (Ageratina altissima) contains the putative toxin tremetone and can produce a disease called “trembles” or “milk sickness”. However the toxicity of tremetone has not been demonstrated in vivo. It has been reported that the plant is less toxic after drying and grinding. The objectives of these studies were to determine: 1) the toxic effect of grinding white snakeroot 4 months prior ...
- DOI:
- 10.1016/j.rvsc.2018.04.006
- https://doi.org/10.1016/j.rvsc.2018.04.006
- Author:
- Bryan L. Stegelmeier, et al. ; Ammon W. Brown; Kevin D. Welch; Show all 3 Authors
- Source:
- Journal of Applied Toxicology 2015 v.35 no.12 pp. 1433-1437
- ISSN:
- 1099-1263
- Subject:
- Oriental traditional medicine; acids; carcinogens; dietary supplements; herbal medicines; history; industry; marketing; phytotoxins; poisoning; product safety; pyrrolizidine alkaloids; risk; toxicity; vegetable products; United States
- Abstract:
- ... In many countries, including the United States, herbal supplements, tisanes and vegetable products, including traditional Chinese medicines, are largely unregulated and their content is not registered, monitored or verified. Consequently, potent plant toxins including dehydropyrrolizidine alkaloids and other potential carcinogens can contaminate these products. As herbal and food supplement produc ...
- Handle:
- 10113/5418161
- DOI:
- 10.1002/jat.3192
- https://doi.org/10.1002/jat.3192
- Author:
- Bryan L. Stegelmeier, et al. ; Reuel A. Field; Steven M. Colegate; Benedict T. Green; Show all 4 Authors
- Source:
- Toxicon 2015 v.97 pp. 36-45
- ISSN:
- 0041-0101
- Subject:
- carcinogenicity; carcinogens; cell viability; chickens; cytotoxicity; hepatocytes; humans; in vitro studies; lactate dehydrogenase; mitochondria; models; monocrotaline; riddelliine; risk; toxicology
- Abstract:
- ... Plants producing dehydropyrrolizidine alkaloids (DHPAs) are found throughout the world and they are dangerous to human and animal health. Several DHPAs are carcinogenic but only riddelliine has been classified as a potential human carcinogen by the National Toxicology Program. As DHPA-related carcinogenicity is probably linked to cytotoxicity, a model of CRL-2118 chicken hepatocyte cytotoxicity wa ...
- Handle:
- 10113/62901
- DOI:
- 10.1016/j.toxicon.2015.02.001
- CHORUS:
- 10.1016/j.toxicon.2015.02.001
- https://doi.org/10.1016/j.toxicon.2015.02.001
- Author:
- Bryan L. Stegelmeier, et al. ; Mark G. Collett; Brian A. Tapper; Show all 3 Authors
- Source:
- Journal of agricultural and food chemistry 2014 v.62 no.30 pp. 7370-7375
- ISSN:
- 0021-8561
- Subject:
- Brassica napus; Brassica rapa subsp. rapa; Pithomyces chartarum; absorption; bile ducts; blood serum; cattle feeds; dairy cows; eczema; enzyme activity; forage crops; gamma-glutamyltransferase; glucobrassicin; gluconapin; glutamate dehydrogenase; hepatotoxicity; histopathology; hydrolysis; liver; nitriles; pastures; photosensitivity; progoitrin; rats; rumen; spores; summer; turnips; New Zealand
- Abstract:
- ... Turnip (Brassica rapa ssp. rapa) and rape (Brassica napus ssp. biennis) and other brassica forage crops are regarded as âsafeâ feed for cattle during late summer and fall in the North Island of New Zealand when high Pithomyces chartarum spore counts in pastures frequently lead to sporidesmin toxicity (facial eczema). Sporadic acute severe cases of turnip photosensitization in dairy cows charac ...
- Handle:
- 10113/4791519
- DOI:
- 10.1021/jf500526u
- https://doi.org/10.1021/jf500526u
- Author:
- Bryan L. Stegelmeier, et al. ; T. Zane Davis; Jeffrey O. Hall; Show all 3 Authors
- Source:
- Journal of agricultural and food chemistry 2014 v.62 no.30 pp. 7393-7397
- ISSN:
- 0021-8561
- Subject:
- forage; grazing; hooves; horses; mass spectrometry; pastures; selenium; selenosis; tail
- Abstract:
- ... Horses are very susceptible to chronic selenosis if grazed on seleniferous forages for a prolonged period. In this study, mane and tail samples from horses that exhibited classical hoof lesions of chronic selenosis were analyzed by inductively coupled plasma mass spectrometry for selenium (Se) content. The horses had grazed for 6 months, from approximately May 15 until November 15, each year for t ...
- Handle:
- 10113/4791522
- DOI:
- 10.1021/jf500861p
- https://doi.org/10.1021/jf500861p
- Author:
- Bryan L. Stegelmeier
- Source:
- veterinary clinics of North America 2011 v.27 no.2 pp. 407-417
- ISSN:
- 0749-0720
- Subject:
- animal diseases; death; laboratory techniques; livestock; livestock and meat industry; poisoning; veterinarians
- Abstract:
- ... Plant poisoning is often associated with a variety of livestock diseases and unexplained animal deaths. Although toxic plants commonly poison livestock and it is estimated to cost the livestock industry in the western United States more than $340 million every year, obtaining a definitive diagnosis is difficult and challenging. The purpose of this article is to provide a framework to help veterina ...
- DOI:
- 10.1016/j.cvfa.2011.02.014
- PubMed:
- 21575777
- https://doi.org/10.1016/j.cvfa.2011.02.014
- Author:
- Bryan L. Stegelmeier
- Source:
- veterinary clinics of North America 2011 v.27 no.2 pp. 419-428
- ISSN:
- 0749-0720
- Subject:
- Amsinckia; Crotalaria; Cynoglossum; Echium; Heliotropium; Senecio; diagnostic techniques; hepatotoxins; humans; livestock; pyrrolizidine alkaloids; toxicity
- Abstract:
- ... Pyrrolizidine alkaloid (PA)–containing plants are found throughout the world and are probably the most common plant cause of poisoning of livestock, wildlife, and humans. PAs are potent liver toxins that under some conditions can be carcinogenic. This article briefly introduces high-risk North American PA-containing plants, summarizing their toxicity and subsequent pathology. Current diagnostic te ...
- DOI:
- 10.1016/j.cvfa.2011.02.013
- https://doi.org/10.1016/j.cvfa.2011.02.013
- Author:
- Bryan L. Stegelmeier, et al. ; Ammon W. Brown; Steven Colegate; Dale R Gardner; Kip E Panter; Edward L Knoppel; Jeffrey O. Hall; Show all 7 Authors
- Source:
- Journal of applied toxicology 2016 v.36 no.5 pp. 716-725
- ISSN:
- 1099-1263
- Subject:
- Gallus gallus; Symphytum officinale; additive effect; blood serum; body weight; chickens; chicks; comfrey; histopathology; males; metabolites; plant extracts; poisoning; pyrrolizidine alkaloids
- Abstract:
- ... Comfrey (Symphytum officinale), a commonly used herb, contains dehydropyrrolizidine alkaloids that, as a group of bioactive metabolites, are potentially hepatotoxic, pneumotoxic, genotoxic and carcinogenic. Consequently, regulatory agencies and international health organizations have recommended comfrey be used for external use only. However, in many locations comfrey continues to be ingested as a ...
- Handle:
- 10113/62999
- DOI:
- 10.1002/jat.3205
- CHORUS:
- 10.1002/jat.3205
- https://doi.org/10.1002/jat.3205
- Author:
- Bryan L. Stegelmeier, et al. ; Kip E. Panter; Show all 2 Author
- Source:
- veterinary clinics of North America 2011 v.27 no.2 pp. 429-446
- ISSN:
- 0749-0720
- Subject:
- animal reproduction; chickens; consultants; phytotoxins; ranchers; scientists; students; veterinarians; xenobiotics
- Abstract:
- ... As man-made chemicals (anthropogenic) are increasing in number and amount of use, it is not uncommon for farmers, ranchers, consultants, or veterinarians to suspect a xenobiotic (strange or foreign substance) as the cause of reproductive failures. In this article, the authors discuss toxicants that have been shown to affect reproduction, with emphasis on food-producing animals and fowl. The discus ...
- DOI:
- 10.1016/j.cvfa.2011.02.010
- PubMed:
- 21575779
- https://doi.org/10.1016/j.cvfa.2011.02.010
- Author:
- Bryan L. Stegelmeier, et al. ; Ammon W. Brown; Steven M. Colegate; Kip E. Panter; Edward L. Knoppel; Jeffery Q. Hall; Show all 6 Authors
- Source:
- Journal of applied toxicology 2015 v.35 no.12 pp. 1557-1563
- ISSN:
- 1099-1263
- Subject:
- animal models; body weight; carcinogenesis; carcinogens; dose response; food availability; hemangiosarcoma; heterozygosity; humans; knockout mutants; liver neoplasms; males; odds ratio; pelleted feeds; riddelliine; rodents; toxicology
- Abstract:
- ... Dehydropyrrolizidine alkaloids (DHPA) are a large, structurally diverse group of plant-derived protoxins that are potentially carcinogenic. With worldwide significance, these alkaloids can contaminate or be naturally present in the human food supply. To develop a small animal model that may be used to compare the carcinogenic potential of the various DHPAs, male heterozygous p53 knockout mice were ...
- Handle:
- 10113/62768
- DOI:
- 10.1002/jat.3120
- CHORUS:
- 10.1002/jat.3120
- https://doi.org/10.1002/jat.3120
- Author:
- Bryan L. Stegelmeier, et al. ; Benedict T. Green; Stephen T. Lee; Kevin D. Welch; Dale R. Gardner; T. Zane Davis; Show all 6 Authors
- Source:
- Research in veterinary science 2015 v.100 pp. 239-244
- ISSN:
- 0034-5288
- Subject:
- Holstein; Lupinus; alkaloids; beef; blood sampling; blood serum; calves; cattle diseases; cattle industry; congenital abnormalities; disease incidence; disease severity; oral administration; pharmacokinetics; phytotoxins; steers; teratogenicity
- Abstract:
- ... Teratogenic alkaloid-containing Lupinus spp. cause congenital defects known as crooked calf disease that is periodically economically devastating for the cattle industry. Previous research indicates that cattle breeds may eliminate plant toxins differently, potentially altering their susceptibility. The objective of this study was to describe the toxicokinetics in Holsteins of anagyrine, the terat ...
- Handle:
- 10113/62784
- DOI:
- 10.1016/j.rvsc.2015.04.001
- https://doi.org/10.1016/j.rvsc.2015.04.001
17. Toxicity of White Snakeroot (Ageratina altissima) and Chemical Extracts of White Snakeroot in Goats
- Author:
- Bryan L. Stegelmeier, et al. ; T. Zane Davis; Stephen T. Lee; Mark G. Collett; Benedict T. Green; Steven R. Buck; James A. Pfister; Show all 7 Authors
- Source:
- Journal of agricultural and food chemistry 2015 v.63 no.7 pp. 2092-2097
- ISSN:
- 0021-8561
- Subject:
- milk sickness; exercise; blood serum; humans; goats; Ageratina altissima; plant extracts; milk; hexane; toxicity; enzyme activity; ketones; poisonous plants; tremetone
- Abstract:
- ... White snakeroot (Ageratina altissima) is a sporadically toxic plant that causes trembles in livestock and milk sickness in humans that drink tainted milk. The putative toxin in white snakeroot is tremetone and possibly other benzofuran ketones, even though it has not been demonstrated in vivo. Toxic white snakeroot was dosed to goats, and they developed clinical signs of poisoning, exercise intole ...
- Handle:
- 10113/62823
- DOI:
- 10.1021/jf505614z
- CHORUS:
- 10.1021/jf505614z
- https://doi.org/10.1021/jf505614z
- Author:
- Bryan L. Stegelmeier, et al. ; Benedict T. Green; Kevin D. Welch; Dale R. Gardner; Stephen T. Lee; Show all 5 Authors
- Source:
- Research in veterinary science 2013 v.95 no.2 pp. 612-615
- ISSN:
- 0034-5288
- Subject:
- Delphinium bicolor; Holstein; alkaloids; blood serum; half life; steers; toxicity
- Abstract:
- ... Low larkspurs have different toxic potentials to livestock due to variation in the individual alkaloids present in the plants. Two species, Delphinium nuttallianum and Delphinium andersonii were dosed to 10 Holstein steers at 10mg and 12mg toxic alkaloids/kg, respectively. Blood samples were collected periodically for 96h, analyzed for serum alkaloid concentrations and toxicokinetic parameters cal ...
- Handle:
- 10113/62994
- DOI:
- 10.1016/j.rvsc.2013.04.018
- PubMed:
- 23664180
- https://doi.org/10.1016/j.rvsc.2013.04.018
- Author:
- Bryan L. Stegelmeier, et al. ; Benedict T. Green; Kip E. Panter; Stephen T. Lee; Kevin D. Welch; James A. Pfister; Dale R. Gardner; T. Zane Davis; Show all 8 Authors
- Source:
- Toxicon 2015 v.106 pp. 1-6
- ISSN:
- 0041-0101
- Subject:
- Angus; Holstein; Lupinus; abnormal development; alkaloids; blood serum; breed differences; calves; cattle diseases; cleft palate; cows; fetus; genetic markers; heifers; herds; pharmacokinetics; pregnancy; selection methods; spine (bones); teratogenicity; ultrasonography
- Abstract:
- ... Calves with congenital defects born to cows that have grazed teratogenic Lupinus spp. during pregnancy can suffer from what is termed crooked calf syndrome. Crooked calf syndrome defects include cleft palate, spinal column defects and limb malformations formed by alkaloid-induced inhibition of fetal movement. In this study, we tested the hypothesis that there are differences in fetal activity of f ...
- Handle:
- 10113/62899
- DOI:
- 10.1016/j.toxicon.2015.08.020
- https://doi.org/10.1016/j.toxicon.2015.08.020
- Author:
- Bryan L. Stegelmeier, et al. ; Yulvian Sani; James A. Pfister; Show all 3 Authors
- Source:
- Journal of veterinary diagnostic investigation v.21 no.2 pp. 208-213
- ISSN:
- 1040-6387
- Subject:
- cows; poisoning; etiology; shrubs; Baccharis; natural toxicants; dietary exposure; toxicity testing; disease models; hamsters; pathogenesis; signs and symptoms (animals and humans); histopathology; liver; kidneys; vasculitis; hemorrhage; infarction; disease severity; dosage
- Abstract:
- ... Baccharis pteronioides DC has been intermittently associated with livestock poisoning in the southwestern United States. In 2004, nearly 100 cows were reported poisoned by B. pteronioides in southern New Mexico. Initial field studies and postmortem examinations found drought conditions, evidence of B. pteronioides consumption, and a reported mortality of nearly 40%. Because postmortem materials we ...
- Handle:
- 10113/30160
- DOI:
- 10.1177/104063870902100205
- PubMed:
- 19286499
- https://doi.org/10.1177/104063870902100205