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- Buraschi, Simone, et al. Show all 9 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.28 pp. E2582
- angiogenesis; autophagy; endothelial cells; gene expression; membrane potential; mitochondrial membrane; proteoglycans; tumor suppressor genes; vascular endothelial growth factor receptor-2; vascular endothelial growth factors
- ... Soluble decorin affects the biology of several receptor tyrosine kinases by triggering receptor internalization and degradation. We found that decorin induced paternally expressed gene 3 (Peg3), an imprinted tumor suppressor gene, and that Peg3 relocated into autophagosomes labeled by Beclin 1 and microtubule-associated light chain 3. Decorin evoked Peg3-dependent autophagy in both microvascular a ...
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